메뉴 건너뛰기




Volumn 2, Issue 2, 2016, Pages 59-71

HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat

(14)  Angelika Ihle, Michaela a   Merkelbach Bruse, Sabine a   Hartmann, Wolfgang a,b   Bauer, Sebastian c   Ratner, Nancy d   Sonobe, Hiroshi e   Nishio, Jun f   Larsson, Olle g   Åman, Pierre h   Pedeutour, Florence i   Taguchi, Takahiro j   Wardelmann, Eva a,b   Buettner, Reinhard a   Schildhaus, Hans Ulrich a,k  


Author keywords

Biomarker; GIST; HDACi; HR23b; RAD23b; Sarcoma

Indexed keywords

BELINOSTAT; BIOLOGICAL MARKER; ENTINOSTAT; MOCETINOSTAT; PROTEIN HR23B; UNCLASSIFIED DRUG; VORINOSTAT;

EID: 84971198009     PISSN: None     EISSN: 20564538     Source Type: Journal    
DOI: 10.1002/cjp2.35     Document Type: Article
Times cited : (9)

References (47)
  • 2
    • 33748581975 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma
    • Spiller SE, Ravanpay AC, Hahn AW, Olson JM. Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma. J Neurooncol 2006;79:259-270.
    • (2006) J Neurooncol , vol.79 , pp. 259-270
    • Spiller, S.E.1    Ravanpay, A.C.2    Hahn, A.W.3    Olson, J.M.4
  • 3
    • 12444321545 scopus 로고    scopus 로고
    • Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously
    • Kelly WK, Richon VM, O'Connor O, et al. Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously. Clin Cancer Res 2003;9(10 Pt 1):3578-3588.
    • (2003) Clin Cancer Res , vol.9 , Issue.10 , pp. 3578-3588
    • Kelly, W.K.1    Richon, V.M.2    O'Connor, O.3
  • 4
    • 77952585540 scopus 로고    scopus 로고
    • Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours
    • Mackay HJ, Hirte H, Colgan T, et al. Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours. Eur J Cancer 2010;46:1573-1579.
    • (2010) Eur J Cancer , vol.46 , pp. 1573-1579
    • Mackay, H.J.1    Hirte, H.2    Colgan, T.3
  • 5
    • 49349104503 scopus 로고    scopus 로고
    • A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia
    • Gimsing P, Hansen M, Knudsen LM, et al. A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia. Eur J Haematol 2008;81:170-176.
    • (2008) Eur J Haematol , vol.81 , pp. 170-176
    • Gimsing, P.1    Hansen, M.2    Knudsen, L.M.3
  • 6
    • 84929265014 scopus 로고    scopus 로고
    • Belinostat approved for use in treating rare lymphoma
    • Thompson CA. Belinostat approved for use in treating rare lymphoma. Am J Health Syst Pharm 2014;71:1328.
    • (2014) Am J Health Syst Pharm , vol.71 , pp. 1328
    • Thompson, C.A.1
  • 7
    • 79955803337 scopus 로고    scopus 로고
    • Mocetinostat (MGCD0103): a review of an isotype-specific histone deacetylase inhibitor
    • Boumber Y, Younes A, Garcia-Manero G. Mocetinostat (MGCD0103): a review of an isotype-specific histone deacetylase inhibitor. Expert Opin Investig Drugs 2011;20:823-829.
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 823-829
    • Boumber, Y.1    Younes, A.2    Garcia-Manero, G.3
  • 8
    • 82555187781 scopus 로고    scopus 로고
    • Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial
    • Younes A, Oki Y, Bociek RG, et al. Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial. Lancet Oncol 2011;12:1222-1228.
    • (2011) Lancet Oncol , vol.12 , pp. 1222-1228
    • Younes, A.1    Oki, Y.2    Bociek, R.G.3
  • 9
    • 85063921541 scopus 로고    scopus 로고
    • U.S. National Institutes of Health; Available from:September
    • US National Institutes of Health Clinical Trials. U.S. National Institutes of Health; Available from: www.clinicaltrials.gov September, 2015.
    • (2015)
  • 10
    • 84655163371 scopus 로고    scopus 로고
    • Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
    • Juergens RA, Wrangle J, Vendetti FP, et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov 2011;1:598-607.
    • (2011) Cancer Discov , vol.1 , pp. 598-607
    • Juergens, R.A.1    Wrangle, J.2    Vendetti, F.P.3
  • 11
    • 77249087051 scopus 로고    scopus 로고
    • Chemical phylogenetics of histone deacetylases
    • Bradner JE, West N, Grachan ML, et al. Chemical phylogenetics of histone deacetylases. Nat Chem Biol 2010;6:238-243.
    • (2010) Nat Chem Biol , vol.6 , pp. 238-243
    • Bradner, J.E.1    West, N.2    Grachan, M.L.3
  • 12
    • 61849144810 scopus 로고    scopus 로고
    • HDAC family: what are the cancer relevant targets?
    • Witt O, Deubzer HE, Milde T, Oehme I. HDAC family: what are the cancer relevant targets? Cancer Lett 2009;277:8-21.
    • (2009) Cancer Lett , vol.277 , pp. 8-21
    • Witt, O.1    Deubzer, H.E.2    Milde, T.3    Oehme, I.4
  • 13
    • 58049208190 scopus 로고    scopus 로고
    • Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis
    • Fotheringham S, Epping MT, Stimson L, et al. Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis. Cancer Cell 2009;15:57-66.
    • (2009) Cancer Cell , vol.15 , pp. 57-66
    • Fotheringham, S.1    Epping, M.T.2    Stimson, L.3
  • 14
    • 0030688064 scopus 로고    scopus 로고
    • Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity
    • Sugasawa K, Ng JM, Masutani C, et al. Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol Cell Biol 1997;17:6924-6931.
    • (1997) Mol Cell Biol , vol.17 , pp. 6924-6931
    • Sugasawa, K.1    Ng, J.M.2    Masutani, C.3
  • 15
    • 84898883434 scopus 로고    scopus 로고
    • Molecular mechanism of global genome nucleotide excision repair
    • Petruseva IO, Evdokimov AN, Lavrik OI. Molecular mechanism of global genome nucleotide excision repair. Acta Naturae 2014;6:23-34.
    • (2014) Acta Naturae , vol.6 , pp. 23-34
    • Petruseva, I.O.1    Evdokimov, A.N.2    Lavrik, O.I.3
  • 16
    • 3042677641 scopus 로고    scopus 로고
    • Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome
    • Elsasser S, Chandler-Militello D, Muller B, Hanna J, Finley D. Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome. J Biol Chem 2004;279:26817-26822.
    • (2004) J Biol Chem , vol.279 , pp. 26817-26822
    • Elsasser, S.1    Chandler-Militello, D.2    Muller, B.3    Hanna, J.4    Finley, D.5
  • 17
    • 18944400164 scopus 로고    scopus 로고
    • Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B
    • Kim B, Ryu KS, Kim HJ, Cho SJ, Choi BS. Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B. FEBS J 2005;272:2467-2476.
    • (2005) FEBS J , vol.272 , pp. 2467-2476
    • Kim, B.1    Ryu, K.S.2    Kim, H.J.3    Cho, S.J.4    Choi, B.S.5
  • 18
    • 84914680415 scopus 로고    scopus 로고
    • Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain
    • Liang RY, Chen L, Ko BT, et al. Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain. J Mol Biol 2014;426:4049-4060.
    • (2014) J Mol Biol , vol.426 , pp. 4049-4060
    • Liang, R.Y.1    Chen, L.2    Ko, B.T.3
  • 19
    • 84866758581 scopus 로고    scopus 로고
    • Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group
    • Yeo W, Chung HC, Chan SL, et al. Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group. J Clin Oncol 2012;30:3361-3367.
    • (2012) J Clin Oncol , vol.30 , pp. 3361-3367
    • Yeo, W.1    Chung, H.C.2    Chan, S.L.3
  • 20
    • 77950877402 scopus 로고    scopus 로고
    • HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy
    • Khan O, Fotheringham S, Wood V, et al. HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy. Proc Natl Acad Sci USA 2010;107:6532-6537.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6532-6537
    • Khan, O.1    Fotheringham, S.2    Wood, V.3
  • 21
    • 84883187700 scopus 로고    scopus 로고
    • A phase II trial of panobinostat in patients with advanced pretreated soft tissue sarcoma. A study from the French Sarcoma Group
    • Cassier PA, Lefranc A, Amela EY, et al. A phase II trial of panobinostat in patients with advanced pretreated soft tissue sarcoma. A study from the French Sarcoma Group. Br J Cancer 2013;109:909-914.
    • (2013) Br J Cancer , vol.109 , pp. 909-914
    • Cassier, P.A.1    Lefranc, A.2    Amela, E.Y.3
  • 22
    • 84929085702 scopus 로고    scopus 로고
    • A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200dagger
    • Chu QS, Nielsen TO, Alcindor T, et al. A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200dagger. Ann Oncol 2015;26:973-981.
    • (2015) Ann Oncol , vol.26 , pp. 973-981
    • Chu, Q.S.1    Nielsen, T.O.2    Alcindor, T.3
  • 23
    • 78649336426 scopus 로고    scopus 로고
    • Soft tissue sarcoma: from molecular diagnosis to selection of treatment. Pathological diagnosis of soft tissue sarcoma amid molecular biology and targeted therapies
    • vii265-vii269
    • Wardelmann E, Schildhaus HU, Merkelbach-Bruse S, et al. Soft tissue sarcoma: from molecular diagnosis to selection of treatment. Pathological diagnosis of soft tissue sarcoma amid molecular biology and targeted therapies. Ann Oncol 2010;21(Suppl 7):vii265- vii269.
    • (2010) Ann Oncol , vol.21
    • Wardelmann, E.1    Schildhaus, H.U.2    Merkelbach-Bruse, S.3
  • 24
    • 84864931514 scopus 로고    scopus 로고
    • Characterization of liposarcoma cell lines for preclinical and biological studies
    • Stratford EW, Castro R, Daffinrud J, et al. Characterization of liposarcoma cell lines for preclinical and biological studies. Sarcoma 2012;2012:148614.
    • (2012) Sarcoma , vol.2012 , pp. 148614
    • Stratford, E.W.1    Castro, R.2    Daffinrud, J.3
  • 25
    • 44049101802 scopus 로고    scopus 로고
    • Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines
    • Dejligbjerg M, Grauslund M, Christensen IJ, et al. Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines. Cancer Biomark 2008;4:101-109.
    • (2008) Cancer Biomark , vol.4 , pp. 101-109
    • Dejligbjerg, M.1    Grauslund, M.2    Christensen, I.J.3
  • 26
    • 0035577768 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells
    • Munster PN, Troso-Sandoval T, Rosen N, Rifkind R, Marks PA, Richon VM. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells. Cancer Res 2001;61:8492-8497.
    • (2001) Cancer Res , vol.61 , pp. 8492-8497
    • Munster, P.N.1    Troso-Sandoval, T.2    Rosen, N.3    Rifkind, R.4    Marks, P.A.5    Richon, V.M.6
  • 27
    • 0030965707 scopus 로고    scopus 로고
    • The clinical role of molecular genetics in soft tissue tumor pathology
    • Busam KJ, Fletcher CD. The clinical role of molecular genetics in soft tissue tumor pathology. Cancer Metastasis Rev 1997;16:207-227.
    • (1997) Cancer Metastasis Rev , vol.16 , pp. 207-227
    • Busam, K.J.1    Fletcher, C.D.2
  • 28
    • 45949083938 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines
    • Yamamoto S, Tanaka K, Sakimura R, et al. Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines. Anticancer Res 2008;28:1585-1591.
    • (2008) Anticancer Res , vol.28 , pp. 1585-1591
    • Yamamoto, S.1    Tanaka, K.2    Sakimura, R.3
  • 29
    • 70149091271 scopus 로고    scopus 로고
    • Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors
    • Muhlenberg T, Zhang Y, Wagner AJ, et al. Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. Cancer Res 2009;69:6941-6950.
    • (2009) Cancer Res , vol.69 , pp. 6941-6950
    • Muhlenberg, T.1    Zhang, Y.2    Wagner, A.J.3
  • 30
    • 49849098245 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models
    • Liu S, Cheng H, Kwan W, Lubieniecka JM, Nielsen TO. Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models. Mol Cancer Ther 2008;7:1751-1761.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1751-1761
    • Liu, S.1    Cheng, H.2    Kwan, W.3    Lubieniecka, J.M.4    Nielsen, T.O.5
  • 31
    • 84863337645 scopus 로고    scopus 로고
    • Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics
    • Su L, Sampaio AV, Jones KB, et al. Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell 2012;21:333-347.
    • (2012) Cancer Cell , vol.21 , pp. 333-347
    • Su, L.1    Sampaio, A.V.2    Jones, K.B.3
  • 32
    • 77951237809 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
    • Hrzenjak A, Moinfar F, Kremser ML, et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer 2010;9:49.
    • (2010) Mol Cancer , vol.9 , pp. 49
    • Hrzenjak, A.1    Moinfar, F.2    Kremser, M.L.3
  • 33
    • 84903741666 scopus 로고    scopus 로고
    • Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA
    • Heinicke U, Fulda S. Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA. Cancer Lett 2014;351:50-58.
    • (2014) Cancer Lett , vol.351 , pp. 50-58
    • Heinicke, U.1    Fulda, S.2
  • 34
    • 34247880441 scopus 로고    scopus 로고
    • Development of histone deacetylase inhibitors for cancer treatment
    • Marchion D, Munster P. Development of histone deacetylase inhibitors for cancer treatment. Expert Rev Anticancer Ther 2007;7:583-598.
    • (2007) Expert Rev Anticancer Ther , vol.7 , pp. 583-598
    • Marchion, D.1    Munster, P.2
  • 35
    • 77950644059 scopus 로고    scopus 로고
    • Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma
    • Wozniak MB, Villuendas R, Bischoff JR, et al. Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma. Haematologica 2010;95:613-621.
    • (2010) Haematologica , vol.95 , pp. 613-621
    • Wozniak, M.B.1    Villuendas, R.2    Bischoff, J.R.3
  • 36
    • 57149105528 scopus 로고    scopus 로고
    • SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway
    • Hrzenjak A, Kremser ML, Strohmeier B, Moinfar F, Zatloukal K, Denk H. SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway. J Pathol 2008;216:495-504.
    • (2008) J Pathol , vol.216 , pp. 495-504
    • Hrzenjak, A.1    Kremser, M.L.2    Strohmeier, B.3    Moinfar, F.4    Zatloukal, K.5    Denk, H.6
  • 37
    • 78650848615 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in the treatment of lymphoma
    • Lemoine M, Younes A. Histone deacetylase inhibitors in the treatment of lymphoma. Discov Med 2010;10:462-470.
    • (2010) Discov Med , vol.10 , pp. 462-470
    • Lemoine, M.1    Younes, A.2
  • 38
    • 84885224051 scopus 로고    scopus 로고
    • A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma: role of cyclin-dependent kinase inhibitors
    • Tula-Sanchez AA, Havas AP, Alonge PJ, et al. A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma: role of cyclin-dependent kinase inhibitors. Cancer Biol Ther 2013;14:949-961.
    • (2013) Cancer Biol Ther , vol.14 , pp. 949-961
    • Tula-Sanchez, A.A.1    Havas, A.P.2    Alonge, P.J.3
  • 39
    • 33845944838 scopus 로고    scopus 로고
    • Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines
    • Larsson DE, Lovborg H, Rickardson L, Larsson R, Oberg K, Granberg D. Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines. Anticancer Res 2006;26:4125-4129.
    • (2006) Anticancer Res , vol.26 , pp. 4125-4129
    • Larsson, D.E.1    Lovborg, H.2    Rickardson, L.3    Larsson, R.4    Oberg, K.5    Granberg, D.6
  • 40
    • 37849019672 scopus 로고    scopus 로고
    • Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
    • Khan N, Jeffers M, Kumar S, et al. Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochem J 2008;409:581-589.
    • (2008) Biochem J , vol.409 , pp. 581-589
    • Khan, N.1    Jeffers, M.2    Kumar, S.3
  • 41
    • 84883794338 scopus 로고    scopus 로고
    • A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors
    • New M, Olzscha H, Liu G, et al. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. Cell Death Differ 2013;20:1306-1316.
    • (2013) Cell Death Differ , vol.20 , pp. 1306-1316
    • New, M.1    Olzscha, H.2    Liu, G.3
  • 42
    • 84883620467 scopus 로고    scopus 로고
    • Long-term complete remission with belinostat in a patient with chemotherapy refractory peripheral t-cell lymphoma
    • Reimer P, Chawla S. Long-term complete remission with belinostat in a patient with chemotherapy refractory peripheral t-cell lymphoma. J Hematol Oncol 2013;6:69.
    • (2013) J Hematol Oncol , vol.6 , pp. 69
    • Reimer, P.1    Chawla, S.2
  • 43
    • 84864004796 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy
    • Witta SE, Jotte RM, Konduri K, et al. Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy. J Clin Oncol 2012;30:2248-2255.
    • (2012) J Clin Oncol , vol.30 , pp. 2248-2255
    • Witta, S.E.1    Jotte, R.M.2    Konduri, K.3
  • 44
    • 16644397236 scopus 로고    scopus 로고
    • Abnormal expression of cell cycle regulators in FUS-CHOP carrying liposarcomas
    • Olofsson A, Willen H, Goransson M, et al. Abnormal expression of cell cycle regulators in FUS-CHOP carrying liposarcomas. Int J Oncol 2004;25:1349-1355.
    • (2004) Int J Oncol , vol.25 , pp. 1349-1355
    • Olofsson, A.1    Willen, H.2    Goransson, M.3
  • 46
    • 0032890294 scopus 로고    scopus 로고
    • Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors
    • Pedeutour F, Forus A, Coindre JM, et al. Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors. Genes Chromosomes Cancer 1999;24:30-41.
    • (1999) Genes Chromosomes Cancer , vol.24 , pp. 30-41
    • Pedeutour, F.1    Forus, A.2    Coindre, J.M.3
  • 47
    • 33750618188 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: pathology and prognosis at different sites
    • Miettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 2006;23:70-83.
    • (2006) Semin Diagn Pathol , vol.23 , pp. 70-83
    • Miettinen, M.1    Lasota, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.