The Effect of Shear on the Structural Conformation of rhGH and IgG1 in Free Solution

Journal of Pharmaceutical Sciences

Volumn 105, Issue 6, 2016, Pages 1810-1818

  Brückl, Lukas ^a,b   Schröder, Thomas ^a   Scheler, Stefan ^a   Hahn, Rainer ^b   Sonderegger, Corinna ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

circular dichroism; IgG antibody; physical stability; protein aggregation; surfactants

Indexed keywords

GUANIDINE; IMMUNOGLOBULIN G1 ANTIBODY; RECOMBINANT GROWTH HORMONE; SURFACTANT; HUMAN GROWTH HORMONE; IMMUNOGLOBULIN G; PROTEIN AGGREGATE; RECOMBINANT PROTEIN;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG CONFORMATION; DRUG STABILITY; LINEAR DICHROISM; MOLECULAR WEIGHT; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; PROTEIN UNFOLDING; SHEAR FLOW; SHEAR RATE; SHEAR STRESS; THERMODYNAMICS; CHEMISTRY; HUMAN; PROTEIN CONFORMATION; SHEAR STRENGTH; SOLUTION AND SOLUBILITY;

HUMAN GROWTH HORMONE; HUMANS; IMMUNOGLOBULIN G; PHARMACEUTICAL SOLUTIONS; PROTEIN AGGREGATES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SHEAR STRENGTH;

EID: 84970973791     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/j.xphs.2016.03.020     Document Type: Article

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