Observational, longitudinal study of delirium in consecutive unselected acute medical admissions: Age-specific rates and associated factors, mortality and re-admission

BMJ Open

Volumn 5, Issue 11, 2015, Pages

  Pendlebury, S T ^a   Lovett, N G ^a   Smith, S C ^a   Dutta, N ^a   Bendon, C ^a   Lloyd Lavery, A ^a   Mehta, Z ^a   Rothwell, P M ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADL DISABILITY; AGED; ARTICLE; COGNITIVE DEFECT; COMORBIDITY; DEATH; DECUBITUS; DEHYDRATION; DELIRIUM; DEMENTIA; DISEASE SEVERITY; EMERGENCY CARE; FALLING; FECES INCONTINENCE; FEMALE; FOLLOW UP; GROUPS BY AGE; HEART RATE; HOSPITAL READMISSION; HUMAN; INDWELLING CATHETER; INFECTION; LENGTH OF STAY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MINI MENTAL STATE EXAMINATION; MORTALITY; OBSERVATIONAL STUDY; RISK ASSESSMENT; SURVIVOR; SYSTOLIC BLOOD PRESSURE; THORAX PAIN; URINE INCONTINENCE; ADOLESCENT; ADULT; AGE DISTRIBUTION; COGNITION DISORDERS; HOSPITALIZATION; INDEPENDENT LIVING; MIDDLE AGED; STATISTICS AND NUMERICAL DATA; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; COGNITION DISORDERS; COMORBIDITY; DELIRIUM; FEMALE; HOSPITALIZATION; HUMANS; INDEPENDENT LIVING; LENGTH OF STAY; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MORTALITY; PATIENT READMISSION; YOUNG ADULT;

EID: 84970934666     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2015-007808     Document Type: Article

References (31)

1. Siddiqi N, House AO, Holmes JD. Occurrence and outcome of delirium in medical in-patients: A systematic literature review. Age Ageing 2006;35:350-64.
2. Delirium, diagnosis, prevention and management. National Institute for Health and Clinical Excellence (NICE) Guideline CG 103http://www.nice.org.uk/CG103.
3. Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet 2014;383:911-22.
4. Hospitals on the Edge, a Time for Action. Royal College Physicians, London, September, 2012. http://www.rcplondon.ac.uk/futurehospital.
5. http://www.rcplondon.ac.uk/sites/default/files/francis-inquirydetailed-response.pdf.
6. Shakespeare J. An unsafe ward. BMJ 2013;346:1243.
7. Krumholz HM. Post-hospital syndrome-an acquired, transient condition of generalized risk. N Engl J Med 2013;368:100-2.
8. Dharmarajan K, Hsieh AF, Lin Z, et al. Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia. JAMA 2013;309:355-63.
9. Carrasco M, Accatino-Scagliotti L, Calderón J, et al. [Delirium in older medical inpatients: A one year follow up study]. Rev Med Chil 2012;140:847-52.
10. Inouye SK, van Dyck CH, Alessi CA, et al. Clarifying confusion: The confusion assessment method. A new method for detection of delirium. Ann Intern Med 1990;113:941-8.
11. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
12. Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing 1972;1:233-8.
13. Cullen B, O'Neill B, Evans JJ, et al. A review of screening tests for cognitive impairment. J Neurol Neurosurg Psychiatr 2007;78: 790-9.
14. Mitchell AJ. A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairment. J Psych Res 2009;43:411-31.
15. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th edn. Washington: American Psychiatric Association, 24 International standard classification. 1994.
16. Charlson M, Szatrowski TP, Peterson J, et al. Validation of a combined comorbidity index. J Clin Epidemiol 1994;47:1245-51.
17. [No authors listed]. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20:864-74.
18. Elia M, ed. Guidelines for detection and management of malnutrition. Malnutrition Advisory Group, Standing Committee of British Association for Parenteral and Enteral Nutrition. Maidenhead: BAPEN, 2000.
19. Waterlow JA. Reliability of the Waterlow score. J Wound Care 1995;4:474-5.
20. Mariz J, Santos NC, Afonso H, et al. Risk and clinical-outcome indicators of delirium in an emergency department intermediate care unit (EDIMCU): An observational prospective study. BMC Emerg Med 2013;13:2.
21. Eeles EM, White SV, O'Mahony SM, et al. The impact of frailty and delirium on mortality in older inpatients. Age Ageing 2012;41:412-16.
22. Whittamore KH, Goldberg SE, Gladman JR, et al. The diagnosis, prevalence and outcome of delirium in a cohort of older people with mental health problems on general hospital wards. Int J Geriatr Psychiatry 2014;29:32-40.
23. Pompei P, Foreman M, Rudberg MA, et al. Delirium in hospitalized older persons: outcomes and predictors. J Am Geriatr Soc 1994;42:809-15.
24. Alagiakrishnan K, Marrie T, Rolfson D, et al. Simple cognitive testing (Mini-Cog) predicts in-hospital delirium in the elderly. J Am Geriatr Soc 2007;55:314-16.
25. Fried LP, Tangen CM, Walston J, et al. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56: M146-M56.
26. Sampson EL, Blanchard MR, Jones L, et al. Dementia in the acute hospital: prospective cohort study of prevalence and mortality. Br J Psychiatry 2009;195:61-6.
27. Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: A systematic review and meta-analysis. Lancet Neurol 2009;8:1006-18.
28. van Gool WA, van de Beek D, Eikelenboom P. Systemic infection and delirium: When cytokines and acetylcholine collide. Lancet 2010;375:773-5.
29. Eggermont LHP, de Boer K, Muller M, et al. Cardiac disease and cognitive impairment: A systematic review. Heart 2012;98:1334-40.
30. Volonghi I, Pendlebury ST, Welch SJ, et al. Cognitive outcomes after acute coronary syndrome: A population based comparison with transient ischaemic attack and minor stroke. Heart 2013;99:1509-14.
31. Report from the Future Hospital Commission to the Royal College of Physicians, September 2013. http://www.rcplondon.ac.uk/projects/future-hospital-commission.