Associations of antibiotic use with risk of primary liver cancer in the Clinical Practice Research Datalink

British Journal of Cancer

Volumn 115, Issue 1, 2016, Pages 85-89

  Yang, Baiyu ^a   Hagberg, Katrina Wilcox ^b   Chen, Jie ^a   Sahasrabuddhe, Vikrant V ^a   Graubard, Barry I ^a   Jick, Susan ^b   McGlynn, Katherine A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

antibiotics; case control study; liver cancer; medical records database

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CHILD; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA BASE; DISEASE ASSOCIATION; DOSE RESPONSE; ELECTRONIC MEDICAL RECORD; FEMALE; HUMAN; LIVER CANCER; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRESCRIPTION; PRIORITY JOURNAL; RISK FACTOR; UNITED KINGDOM; CHEMICALLY INDUCED; DRUG EFFECTS; LIVER NEOPLASMS; MEDICAL RESEARCH; MICROFLORA; MIDDLE AGED; ODDS RATIO; PROCEDURES; STATISTICAL MODEL; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BIOMEDICAL RESEARCH; CASE-CONTROL STUDIES; FEMALE; HUMANS; LIVER NEOPLASMS; LOGISTIC MODELS; MALE; MICROBIOTA; MIDDLE AGED; ODDS RATIO; RISK FACTORS; UNITED KINGDOM;

EID: 84969941218     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2016.148     Document Type: Article

References (9)

1. Boursi B, Mamtani R, Haynes K, Yang Y-X. (2015). Recurrent antibiotic exposure may promote cancer formation-Another step in understanding the role of the human microbiota? Eur J Cancer 51(17): 2655-2664
2. Clemente Jose C, Ursell Luke K, Parfrey Laura W, Knight R. (2012). The impact of the gut microbiota on human health: an integrative view. Cell 148(6): 1258-1270
3. Jick H, Jick SS, Derby LE. (1991). Validation of information recorded on general practitioner based computerised data resource in the United Kingdom. BMJ 302(6779): 766-768
4. Jick SS, Kaye JA, Vasilakis-Scaramozza C, Rodríguez LAG, Ruigómez A, Meier CR, Schlienger RG, Black C, Jick H. (2003). Validity of the general practice research database. Pharmacotherapy 23(5): 686-689
5. Joshi N, Caputo GM, Weitekamp MR, Karchmer AW. (1999). Infections in patients with diabetes mellitus. N Engl J Med 341(25): 1906-1912
6. Kilkkinen A, Rissanen H, Klaukka T, Pukkala E, Heliövaara M, Huovinen P, MännistöS, Aromaa A, Knekt P. (2008). Antibiotic use predicts an increased risk of cancer. Int J Cancer 123(9): 2152-2155
7. Lawson DH, Sherman V, Hollowell J. (1998). The General Practice Research Database. Scientific and Ethical Advisory Group. QJM 91(6): 445-452
8. Navasa M, Rimola A, Rodés J. (1997). Bacterial infections in liver disease. Semin Liver Dis 17(4): 323-333
9. Schwabe RF, Jobin C. (2013). The microbiome and cancer. Nat Rev Cancer 13(11): 800-812