The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes

Journal of Diabetes Research

Volumn 2016, Issue , 2016, Pages

  Forlani, Gabriele ^a   Giorda, Carlo ^b   Manti, Roberta ^b   Mazzella, Natalia ^a   De Cosmo, Salvatore ^c   Rossi, Maria Chiara ^d   Nicolucci, Antonio ^d   Di Bartolo, Paolo ^e   Ceriello, Antonio ^f   Guida, Pietro ^g  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b ASL Torino 5   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d Center for Outcomes Research and Clinical Epidemiology   (Italy)

^e AUSL   (Italy)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

^g AMD (Italian Association of Clinical Diabetologists)   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; BIOLOGICAL MARKER; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BLOOD PRESSURE; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETIC PATIENT; ELECTRONIC MEDICAL RECORD; FEMALE; HEALTH CARE QUALITY; HUMAN; ITALY; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; PREVALENCE; BLOOD; COMORBIDITY; DIABETES MELLITUS, TYPE 2; FACTUAL DATABASE; HEALTH SURVEY; MIDDLE AGED; MULTIVARIATE ANALYSIS; NON-ALCOHOLIC FATTY LIVER DISEASE; ODDS RATIO; PROGNOSIS; RISK FACTOR; STATISTICAL MODEL;

AGED; BIOMARKERS; COMORBIDITY; CROSS-SECTIONAL STUDIES; DATABASES, FACTUAL; DIABETES MELLITUS, TYPE 2; FEMALE; HEALTH SURVEYS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; ITALY; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NON-ALCOHOLIC FATTY LIVER DISEASE; ODDS RATIO; PREVALENCE; PROGNOSIS; RISK FACTORS;

EID: 84969919439     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2016/2931985     Document Type: Article

References (32)

1. K. H. Williams, N. A. Shackel, M. D. Gorrell, S. V. McLennan, and S. M. Twigg, "Diabetes and nonalcoholic fatty liver disease: a pathogenic duo, " Endocrine Reviews, vol. 34, no. 1, pp. 84-129, 2013.
2. G. Marchesini, M. Brizi, G. Blanchi et al., "Nonalcoholic fatty liver disease: a feature of the metabolic syndrome, " Diabetes, vol. 50, no. 8, pp. 1844-1850, 2001.
3. G. Musso, R. Gambino, M. Cassader, and G. Pagano, "Metaanalysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity, " Annals of Medicine, vol. 43, no. 8, pp. 617-649, 2011.
4. N. C. Leite, C. A. Villela-Nogueira, V. L. N. Pannain et al., "Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors, " Liver International, vol. 31, no. 5, pp. 700-706, 2011.
5. N. Hossain, A. Afendy, M. Stepanova et al., "Independent predictors of fibrosis in patients with nonalcoholic fatty liver disease, " Clinical Gastroenterology and Hepatology, vol. 7, no. 11, pp. 1224. e2-1229. e2, 2009.
6. S. Moscatiello, R. Manini, and G. Marchesini, "Diabetes and liver disease: an ominous association, " Nutrition, Metabolism and Cardiovascular Diseases, vol. 17, no. 1, pp. 63-70, 2007.
7. G. Targher and C. D. Byrne, "Nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications, " Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 2, pp. 483-495, 2013.
8. G. Musso, R. Gambino, J. H. Tabibian et al., "Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic reviewandmeta-analysis, " PLoSMedicine, vol. 11, no. 7, Article ID e1001680, 2014.
9. G. Targher, C. P. Day, and E. Bonora, "Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease, " The New England Journal ofMedicine, vol. 363, no. 14, pp. 1341-1350, 2010.
10. C.-J. Bergqvist, R. Skoien, L. Horsfall, A. D. Clouston, J. R. Jonsson, and E. E. Powell, "Awareness and opinions of nonalcoholic fatty liver disease by hospital specialists, " Internal Medicine Journal, vol. 43, no. 3, pp. 247-253, 2013.
11. A. L. Fracanzani, L. Valenti, E. Bugianesi et al., "Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes, " Hepatology, vol. 48, no. 3, pp. 792-798, 2008.
12. A. E. Bohte, J. R. van Werven, S. Bipat, and J. Stoker, "The diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis, " European Radiology, vol. 21, no. 1, pp. 87-97, 2011.
13. G. Marchesini and G. Forlani, "Diabetes and hepatocellular cancer risk: not only a matter of hyperglycemia, " Hepatology, vol. 55, no. 4, pp. 1298-1300, 2012.
14. G. Bedogni, S. Bellentani, L. Miglioli et al., "The fatty liver index: a simple and accurate predictor of hepatic steatosis in the general population, " BMC Gastroenterology, vol. 6, article 33, 2006.
15. C. E. Ruhl and J. E. Everhart, "Fatty liver indices inthemultiethnic United States National Health and Nutrition Examination Survey, " Alimentary Pharmacology andTherapeutics, vol. 41, no. 1, pp. 65-76, 2015.
16. A. Gastaldelli, M. Kozakova, K. Höjlund et al., "Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population, " Hepatology, vol. 49, no. 5, pp. 1537-1544, 2009.
17. G. Calori, G. Lattuada, F. Ragogna et al., "Fatty liver index and mortality: the cremona study in the 15th year of follow-up, " Hepatology, vol. 54, no. 1, pp. 145-152, 2011.
18. Gruppo di Studio Annali AMD, "AMD annals: a model of continuous monitoring and improvement of the quality of diabetes care, " Epidemiologia e Prevenzione, vol. 35, no. 1, pp. 18-26, 2011.
19. A. Nicolucci, M. C. Rossi, A. Arcangeli et al., "Four-year impact of a continuous quality improvement effort implemented by a network of diabetes outpatient clinics: the AMD-Annals initiative, " Diabetic Medicine, vol. 27, no. 9, pp. 1041-1048, 2010.
20. N. Chalasani, Z. Younossi, J. E. Lavine et al., "The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, AmericanCollege of Gastroenterology, and the American GastroenterologicalAssociation, " Hepatology, vol. 55, no. 6, pp. 2005-2023, 2012.
21. A. Vallet-Pichard, V. Mallet, B. Nalpas et al., "FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and FibroTest, " Hepatology, vol. 46, no. 1, pp. 32-36, 2007.
22. D. Prati, E. Taioli, A. Zanella et al., "Updated definitions of healthy ranges for serum alanine aminotransferase levels, " Annals of Internal Medicine, vol. 137, no. 1, pp. 1-10, 2002.
23. A. S. Levey, L. A. Stevens, C. H. Schmid et al., "Anewequation to estimate glomerular filtration rate, " Annals of Internal Medicine, vol. 150, no. 9, pp. 604-612, 2009.
24. M. C. E. Rossi, G. Lucisano, M. Comaschi et al., "Quality of diabetes care predicts the development of cardiovascular events: results of the AMD-quasar study, " Diabetes Care, vol. 34, no. 2, pp. 347-352, 2011.
25. R. J. Wong, M. Aguilar, R. Cheung et al., "Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States, " Gastroenterology, vol. 148, no. 3, pp. 547-555, 2015.
26. G. Targher, M. Chonchol, G. Zoppini, C. Abaterusso, and E. Bonora, "Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link?" Journal of Hepatology, vol. 54, no. 5, pp. 1020-1029, 2011.
27. J. H. Ix and K. Sharma, "Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK, " Journal of the American Society of Nephrology, vol. 21, no. 3, pp. 406-412, 2010.
28. Y. Li, L. Liu, B. Wang, J. Wang, and D. Chen, "Simple steatosis is a more relevant source of serum inflammatory markers than omental adipose tissue, " Clinics and Research in Hepatology and Gastroenterology, vol. 38, no. 1, pp. 46-54, 2014.
29. G. Targher, L. Bertolini, S. Rodella et al., "Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/lasertreated retinopathy in type 2 diabetic patients, " Diabetologia, vol. 51, no. 3, pp. 444-450, 2008.
30. G. Zoppini, U. Fedeli, N. Gennaro, M. Saugo, G. Targher, and E. Bonora, "Mortality from chronic liver diseases in diabetes, " American Journal of Gastroenterology, vol. 109, no. 7, pp. 1020-1025, 2014.
31. M. C. Rossi, M. R. Cristofaro, S. Gentile et al., "Sex disparities in the quality of diabetes care: biological and cultural factors may play a different role for different outcomes: a cross-sectional observational study from the amd annals initiative, " Diabetes Care, vol. 36, no. 10, pp. 3162-3168, 2013.
32. V. Soverini, M. Persico, E. Bugianesi et al., "HBV and HCV infection in type 2 diabetes mellitus: a survey in three diabetes units in different Italian areas, " Acta Diabetologica, vol. 48, no. 4, pp. 337-343, 2011.