Microfluidic Directed Synthesis of Alginate Nanogels with Tunable Pore Size for Efficient Protein Delivery

Langmuir

Volumn 32, Issue 19, 2016, Pages 4996-5003

  Bazban Shotorbani, Salime ^a   Dashtimoghadam, Erfan ^b   Karkhaneh, Akbar ^a   Hasani Sadrabadi, Mohammad Mahdi ^a,c   Jacob, Karl I ^c,d  

^a AMIRKABIR UNIVERSITY OF TECHNOLOGY   (Iran)

^b MARQUETTE UNIVERSITY SCHOOL OF DENTISTRY   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d Georgia Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINATE; BIOSYNTHESIS; ENCAPSULATION; MICROFLUIDICS; PH SENSORS; PORE SIZE; PROTEINS;

ADJUSTABLE PORE SIZE; AGGREGATION NUMBERS; AVERAGE MOLECULAR WEIGHT; CROSS-JUNCTION MICROCHANNEL; ENCAPSULATION EFFICIENCY; EQUILIBRIUM SWELLING; MICROFLUIDIC PLATFORMS; SYNTHESIS PARAMETERS;

NANOSTRUCTURED MATERIALS;

ALGINIC ACID; BOVINE SERUM ALBUMIN; DRUG CARRIER; GLUCURONIC ACID; HEXURONIC ACID; NANOMATERIAL; POLYETHYLENEIMINE;

ANIMAL; BOVINE; CHEMISTRY; DEVICES; DRUG RELEASE; GEL; HYDRODYNAMICS; LAB ON A CHIP; MOLECULAR WEIGHT; PH; SYNTHESIS;

ALGINATES; ANIMALS; CATTLE; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG CARRIERS; DRUG LIBERATION; GELS; GLUCURONIC ACID; HEXURONIC ACIDS; HYDRODYNAMICS; HYDROGEN-ION CONCENTRATION; LAB-ON-A-CHIP DEVICES; MOLECULAR WEIGHT; NANOSTRUCTURES; POLYETHYLENEIMINE; SERUM ALBUMIN, BOVINE;

EID: 84969895633     PISSN: 07437463     EISSN: 15205827     Source Type: Journal    
DOI: 10.1021/acs.langmuir.5b04645     Document Type: Article

References (35)

1. Shi, J. et al. Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications Nano Lett. 2010, 10, 3223-3230 10.1021/nl102184c
2. Farokhzad, O. C.; Langer, R. Nanomedicine: Developing smarter therapeutic and diagnostic modalities Adv. Drug Delivery Rev. 2006, 58, 1456-1459 10.1016/j.addr.2006.09.011
3. Yih, T. C.; Al-Fandim, M. Engineered Nanoparticles as Precise Drug Delivery Systems J. Cell. Biochem. 2006, 97, 1184-1190 10.1002/jcb.20796
4. Zhang, L. et al. Nanoparticles in Medicine: Therapeutic Applications and Developments Clin. Pharmacol. Ther. 2008, 83 (5) 761-769 10.1038/sj.clpt.6100400
5. Hasani-Sadrabadi, M. M. et al. Morphological Tuning of Polymeric Nanoparticles via Microfluidic Platform for Fuel Cell Applications J. Am. Chem. Soc. 2012, 134, 18904-18907 10.1021/ja307751a
6. Majedi, F. S. et al. Microfluidic assisted self-assembly of chitosan based nanoparticles as drug delivery agents Lab Chip 2013, 13, 204-207 10.1039/C2LC41045A
7. Majedi, F. S. et al. On-Chip Fabrication of Paclitaxel-Loaded Chitosan Nanoparticles for Cancer Therapeutics Adv. Funct. Mater. 2014, 24 (4) 432-441 10.1002/adfm.201301628
8. Majedi, F. S. et al. Microfluidic synthesis of chitosan-based nanoparticles for fuel cell applications Chem. Commun. 2012, 48, 7744-7746 10.1039/c2cc33253a
9. Flory, P. J. Principles of Polymer Chemistry; Cornell University Press: Ithaca, NY, 1953.
10. George, M.; Abraham, T. E. Polyionic hydrocolloids for the intestinal delivery of protein drugs:Alginate and chitosan - a review J. Controlled Release 2006, 114, 1-14 10.1016/j.jconrel.2006.04.017
11. Lee, K. Y.; Mooney, D. J. Alginate: Properties and biomedical applications Prog. Polym. Sci. 2012, 37, 106-126 10.1016/j.progpolymsci.2011.06.003
12. Pawar, S. N.; Edgar, K. J. Alginate derivatization: A review of chemistry, properties and applications Biomaterials 2012, 33, 3279-3305 10.1016/j.biomaterials.2012.01.007
13. Gombotz, W. R.; Wee, S. F. Protein release from alginate matrices Adv. Drug Delivery Rev. 2012, 64, 194-205 10.1016/j.addr.2012.09.007
14. Lu, Y.; Sun, W.; Gu, Z. Stimuli-responsive nanomaterials for therapeutic protein delivery J. Controlled Release 2014, 194, 1-19 10.1016/j.jconrel.2014.08.015
15. Karnik, R. et al. Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles Nano Lett. 2008, 8, 2906-2912 10.1021/nl801736q
16. Ribeiro, A. C. et al. Diffusion coefficients and electrical conductivities for calcium chloride aqueous solutions at 298.15 and 310.15 K Electrochim. Acta 2008, 54 (2) 192-196 10.1016/j.electacta.2008.08.011
17. Rockville, M. D. United States Pharmacopeia and National Formulary, 26 th ed.; United States Pharmacopeial Convention Inc.: 2003.
18. Jonassen, H.; Kjøniksen, A.-L. Optical-scattering method for the determination of the local polymer concentration inside nanoparticles Phys. Rev. E 2011, 84, 022401 10.1103/PhysRevE.84.022401
19. Qiu, Y.; Park, K. Environment-sensitive hydrogels for drug delivery Adv. Drug Delivery Rev. 2012, 64, 49-60 10.1016/j.addr.2012.09.024
20. Brannon-Peppas, L.; Peppas, N. A. Equilibrium swelling behavior of pH-sensitive hydrogels Chem. Eng. Sci. 1991, 46 (3) 715-722 10.1016/0009-2509(91)80177-Z
21. Moe, S. T. et al. Swelling of Covalently Crosslinked Alginate Gels: Influence of Ionic Solutes and Nonpolar Solvents Macromolecules 1993, 26, 3589-3591 10.1021/ma00066a017
22. Dashtimoghadam, E. et al. Microfluidic self-assembly of polymeric nanoparticles with tunable compactness for controlled drug delivery Polymer 2013, 54 (18) 4972-4979 10.1016/j.polymer.2013.07.022
23. Flory, p.J.; Rehner, J. R. Statistical Mechanics of Cross-Linked Polymer Networks I. Rubberlike Elasticity J. Chem. Phys. 1943, 11 (11) 512-520 10.1063/1.1723791
24. Flory, P. J.; Rehner, J. R. Statistical Mechanics of Cross-Linked Polymer Networks II J. Chem. Phys. 1943, 11 (11) 521-526 10.1063/1.1723792
25. Brannon-Peppas, L.; Peppas, N. A. Equilibrium swelling behavior of dilute ionic hydrogels in electrolytic solutions J. Controlled Release 1991, 16, 319-330 10.1016/0168-3659(91)90009-3
26. Lee, K. Y. et al. Controlling Mechanical and Swelling Properties of Alginate HydrogelsIndependently by Cross-Linker Type and Cross-Linking Density Macromolecules 2000, 33, 4291-4294 10.1021/ma9921347
27. Slaughter, B. V. et al. Hydrogels in Regenerative Medicine Adv. Mater. 2009, 21, 3307-3329 10.1002/adma.200802106
28. Amsden, B.; Turner, N. Diffusion Characteristics of Calcium Alginate Gels Biotechnol. Bioeng. 1999, 65, 605-610 10.1002/(SICI)1097-0290(19991205)65:5<605::AID-BIT14>3.0.CO;2-C
29. Chan, A. W.; Neufeld, R. J. Modeling the controllable pH-responsive swelling and pore size of networked alginate based biomaterials Biomaterials 2009, 30, 6119-6129 10.1016/j.biomaterials.2009.07.034
30. Leonard, M. et al. Hydrophobically modified alginate hydrogels as protein carriers with specific controlled release properties J. Controlled Release 2004, 98 (3) 395-405 10.1016/j.jconrel.2004.05.009
31. Bernkop-Schnürch, A.; Kast, C. E.; Richter, M. F. Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine J. Controlled Release 2001, 71 (3) 277-285 10.1016/S0168-3659(01)00227-9
32. Martínez, A. et al. Synthesis and characterization of thiolated alginate-albumin nanoparticles stabilized by disulfide bonds. Evaluation as drug delivery systems Carbohydr. Polym. 2011, 83 (3) 1311-1321 10.1016/j.carbpol.2010.09.038
33. Patil, J. et al. Ionotropic gelation and polyelectrolyte complexation: the novel techniques to design hydrogel particulate sustained, modulated drug delivery system: a review Digest J. Nanomater. Biostruct. 2010, 5 (1) 241-248
34. Sarmento, B. et al. Alginate/chitosan nanoparticles are effective for oral insulin delivery Pharm. Res. 2007, 24 (12) 2198-2206 10.1007/s11095-007-9367-4
35. Saltzman, W. M. Drug Delivery: Engineering Principles for Drug Therapy; Oxford University Press: 2001.