Effects of single low dose of dexamethasone before noncardiac and nonneurologic surgery and general anesthesia on postoperative cognitive dysfunction - A phase III double blind, randomized clinical trial

PLoS ONE

Volumn 11, Issue 5, 2016, Pages

  Valentin, Livia Stocco Sanches ^a   Pereira, Valeria Fontenelle Angelim ^a   Pietrobon, Ricardo S ^b   Schmidt, Andre P ^c,d   Oses, Jean P ^e   Portela, Luis V ^c   Souza, Diogo O ^c   Vissoci, João Ricardo Nickenig ^b,g   Da Luz, Vinicius Fernando ^a   De Souza Trintoni, Leticia Maria De Araujo ^a   Nielsen, Karen C ^f   Carmona, Maria José Carvalho ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b DUKE UNIVERSITY HEALTH SYSTEM   (United States)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d Hospital de Porto Alegre   (Brazil)

^e CATHOLIC UNIVERSITY OF PELOTAS   (Brazil)

^f DUKE UNIVERSITY MEDICAL CENTER   (United States)

^g Departamento de Ortodontia   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; PROTEIN S100B;

ADULT; AGED; ANESTHESIA INDUCTION; ARTICLE; BISPECTRAL INDEX; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXECUTIVE FUNCTION; GENERAL ANESTHESIA; HUMAN; INCIDENCE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MEMORY; NEUROPROTECTION; NEUROPSYCHOLOGICAL TEST; PHASE 3 CLINICAL TRIAL; POSTOPERATIVE COGNITIVE DYSFUNCTION; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; ADVERSE EFFECTS; CLINICAL TRIAL; COGNITION DISORDERS; DOSE RESPONSE; FEMALE; MALE; MIDDLE AGED; PREOPERATIVE CARE; PSYCHOLOGY; SURGERY;

AGED; COGNITION DISORDERS; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PREOPERATIVE CARE; SURGICAL PROCEDURES, OPERATIVE;

EID: 84969780223     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0152308     Document Type: Article

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