Serum vitamin D levels correlate to coronary artery disease severity: a retrospective chart analysis

Expert Review of Cardiovascular Therapy

Volumn 14, Issue 8, 2016, Pages 977-982

  Sogomonian, Robert ^a   Alkhawam, Hassan ^a   Jolly, JoshPaul ^a   Vyas, Neil ^a   Ahmad, Sumair ^a   Haftevani, Emma Moradoghli ^b   Al Khazraji, Ahmed ^a   Finkielstein, Dennis ^a   Vittorio, Timothy J ^c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ROSS UNIVERSITY SCHOOL OF MEDICINE   (Dominica)

^c ST FRANCIS HOSPITAL   (United States)

Author keywords

25(OH)D; Coronary artery disease; obstructive CAD; retrospective; vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; VITAMIN D;

ADULT; AGE; ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; CORONARY ANGIOGRAPHY; CORONARY ARTERY OBSTRUCTION; CORRELATIONAL STUDY; DISEASE SEVERITY; ETHNICITY; FEMALE; GENDER; HUMAN; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; RADIATION INJURY; RETROSPECTIVE STUDY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STABLE ANGINA PECTORIS; THORAX PAIN; UNSTABLE ANGINA PECTORIS; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; ADVERSE EFFECTS; AGED; BLOOD; COMORBIDITY; COMPLICATION; CORONARY ARTERY DISEASE; MIDDLE AGED; PATHOPHYSIOLOGY; RISK FACTOR; SEVERITY OF ILLNESS INDEX;

AGED; COMORBIDITY; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84969764572     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1080/14779072.2016.1190273     Document Type: Article

References (30)

1. K.Okrainec, D.K.Banerjee, M.J.Eisenberg Coronary artery disease in the developing world. Am Heart J. 2004;148(1):7–15.
2. U.N.Khot, M.B.Khot, C.T.Bajzer, et al. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA. 2003;290(7):898–904.
3. B.Schöttker, R.Jorde, A.Peasey, et al. Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States. BMJ. 2014; 17;348:g3656.
4. S.E.Judd, V.Tangpricha. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci. 2009;338(1):40–44.
5. K.S.Vimaleswaran, A.Cavadino, D.J.Berry, et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a Mendelian randomization study. Lancet Diabetes Endocrinol. 2014;2(9):719–729.• Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension.
6. P.Brøndum-Jacobsen, M.Benn, G.B.Jensen, et al. 25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies. Arterioscler Thromb Vasc Biol. 2012;32(11):2794–2802.• Meta-analyses: Observed increasing risk of ischemic heart disease, myocardial infarction, and early death with decreasing plasma 25-hydroxyvitamin D levels.
7. S.S.Gunta, R.I.Thadhani, R.H.Mak. The effect of vitamin D status on risk factors for cardiovascular disease. Nat Rev Nephrol. 2013;9(6):337–347.
8. D.J.Lerner, W.B.Kannel. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986;111(2):383–390.
9. D.M.Lloyd-Jones, M.G.Larson, A.Beiser, et al. Lifetime risk of developing coronary heart disease. Lancet. 1999; 9; 353(9147):89–92.
10. D.H.Kim, S.Sabour, U.N.Sagar, et al. Prevalence of hypovitaminosis D in cardiovascular diseases (from the national health and nutrition examination survey 2001 to 2004). Am J Cardiol. 2008 1; 102(11):1540–154b.
11. J.Kendrick, G.Targher, G.Smits, et al. 25-hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the third national health and nutrition examination survey. Atherosclerosis. 2009;205(1):255–260.•• A strong and independent relationship of 25(OH)D deficiency with prevalent CVD.
12. T.J.Wang, M.J.Pencina, S.L.Booth, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008; 29;117(4):503–511.•• Based on Framingham Offspring Study: Vitamin D deficiency is associated with incident cardiovascular disease.
13. L.Wang, Y.Song, J.E.Manson, et al. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes. 2012;5(6):819–829.
14. R.Bouillon, G.Carmeliet, L.Verlinden, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008;29(6):726–776.
15. F.Akin, B.Ayça, N.Köse, et al. Serum vitamin D levels are independently associated with severity of coronary artery disease. J Investig Med. 2012;60(6):869–873.
16. W.R.Chen, Y.A.Qian, Y.D.Chen, et al. The effects of low vitamin D on coronary artery disease. Heart Lung Circ. 2014;23(4):314–319.
17. A.A.Quyyumi. Prognostic value of endothelial function. Am J Cardiol. 2003; 19; 91(12A):19H–24H.
18. J.Davignon, P.Ganz. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109:III27–III32.
19. S.K.Syal, A.Kapoor, E.Bhatia, et al. Vitamin D deficiency, coronary artery disease, and endothelial dysfunction: observations from a coronary angiographic study in Indian patients. J Invasive Cardiol. 2012;24(8):385–389.
20. A.Zittermann, S.S.Schleithoff, R.Koerfer. Putting cardiovascular disease and vitamin d insufficiency into perspective. Br J Nutr. 2005;94:483–492.
21. J.H.Lee, J.H.O’Keefe, D.Bell, et al. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol. 2008; 9. 52(24):1949–1956.
22. P.A.Naesgaard, R.A.León De La Fuente, S.T.Nilsen, et al. Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina. PLoS One. 2012;7(9):e43228.•• Vitamin D was could to be a useful biomarker for prediction of mortality for patients with suspected acute coronary syndrome.
23. A.W.Norman, J.B.Frankel, A.M.Heldt. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science. 1980;209:823–825.
24. Y.C.Li, J.Kong, M.Wei, et al. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. 2002;110(2):229–238.
25. S.G.Rostand. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. 1997;30(2 Pt 1):150–156.
26. C.Robinson-Cohen, A.N.Hoofnagle, J.H.Ix. Racial differences in the association of serum 25-hydroxyvitamin D concentration with coronary heart disease events. JAMA. 2013;310(2):179–188.
27. J.A.Ford, G.S.MacLennan, A.Avenell, et al. Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis. Am J Clin Nutr. 2014;100(3):746–755.• Vitamin D supplementation might protect against cardiac failure in older people but does not appear to protect against MI or stroke.
28. M.P.Ponda, K.Dowd, D.Finkielstein, et al. The short-term effects of vitamin D repletion on cholesterol: a randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol. 2012;32(10):2510–2515.• A randomized, placebo-controlled trial to determine the short-term effects of vitamin D repletion on the lipid profile.
29. L.A.Beveridge, A.D.Struthers, F.Khan, et al. Effect of vitamin D supplementation on blood pressure: a systematic review and meta-analysis incorporating individual patient data. JAMA Int Med. 2015;175(5):745–754.•• Systematically review whether supplementation with vitamin D or its analogues reduce BP.
30. J.Dong, S.L.Wong, C.W.Lau, et al. Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J. 2012;33(23):2980–2990.