Aberrant expression of long noncoding RNA PVT1 and its diagnostic and prognostic significance in patients with gastric cancer

Neoplasma

Volumn 63, Issue 3, 2016, Pages 442-449

  Yuan, C L ^a,b   Li, H ^c   Zhu, L ^d   Liu, Z ^b   Zhou, J ^e   Shu, Y ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b The First People s Hospital of Lianyungang   (China)

^c AFFILIATED HOSPITAL OF NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d The First People s Hospital of Lianyungang City   (China)

^e NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Clinical relevance; Gastric cancer; Long noncoding RNA; PVT1

Indexed keywords

LONG UNTRANSLATED RNA; PEPTIDES AND PROTEINS; PROTEIN PVT1; UNCLASSIFIED DRUG; PVT1 LONG-NON-CODING RNA, HUMAN;

ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER PROGNOSIS; CANCER STAGING; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE FREE SURVIVAL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; OVERALL SURVIVAL; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; TUMOR INVASION; UPREGULATION; BIOSYNTHESIS; DNA MICROARRAY; GENETICS; KAPLAN MEIER METHOD; MIDDLE AGED; PROGNOSIS; STOMACH TUMOR; TUMOR CELL LINE;

CELL LINE, TUMOR; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM STAGING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; RNA, LONG NONCODING; STOMACH NEOPLASMS; UP-REGULATION;

EID: 84969642668     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/314_150825N45     Document Type: Article

References (33)

1. MOORE MA, ATTASARA P, KHUHAPREMA T, LE TN, NGUYEN TH et al. Cancer epidemiology in mainland SouthEast Asia-past, present and future. Asian Pac J Cancer Prev 2010; 11: 67-80.
2. JEMAL A, SIEGEL R, XU J, WARD E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60: 277-300. http://dx. doi. org/10. 3322/caac. 20073.
3. SAPARI NS, LOH M, VAITHILINGAM A, SOONG R. Clinical Potential of DNA Methylation in Gastric Cancer: A Meta-Analysis. Plos One 2012; 7.
4. MILNE AN, CARNEIRO F, O'MORAIN C, OFFERHAUS GJA. Nature meets nurture: molecular genetics of gastric cancer. Human Genetics 2009; 126: 615-628. http://dx. doi. org/10. 1007/s00439-009-0722-x.
5. MUERS M. RNA Genome-wide views of long non-coding RNAs. Nature Reviews Genetics 2011; 12. http://dx. doi. org/10. 1038/nrg3088.
6. PONTING CP, OLIVER PL, REIK W. Evolution and Functions of Long Noncoding RNAs. Cell 2009; 136: 629-641. http://dx. doi. org/10. 1016/j. cell. 2009. 02. 006.
7. RINN JL, KERTESZ M, WANG JK, SQUAZZO SL, XU X et al. Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs. Cell 2007; 129: 1311-1323. http://dx. doi. org/10. 1016/ixell. 2007. 05. 022.
8. CALIN GA, LIU CG, FERRACIN M, HYSLOP T, SPIZZO R et al. Ultraconserved regions encoding ncRNAs are, altered in human leukemias and carcinomas. Cancer Cell 2007; 12: 215-229. http://dx. doi. org/10. 1016/ixcr. 2007. 07. 027.
9. LIN R, MAEDA S, LIU C, KARIN M, EDGINGTON TS. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene 2007; 26: 851-858. http://dx. doi. org/10. 1038/si. onc. 1209846.
10. HIRATA H, HINODA Y, SHAHRYARI V, DENG GR, NA-KAJIMA K et al. Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205. Cancer Research 2015; 75: 1322-1331. http://dx. doi. org/10. 1158/0008-5472. CAN-14-2931.
11. OKUGAWA Y, TOIYAMA Y, HUR K, TODEN S, SAIGUSA S et al. Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis 2014; 35: 2731-2739. http://dx. doi. org/10. 1093/carcin/bgu200.
12. SUN M, JIN FY, XIA R, KONG R, LI JH et al. Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer. Bmc Cancer 2014; 14. http://dx. doi. org/10. 1186/1471-2407-14-319.
13. SUN M, XIA R, JIN FY, XU TP, LIU ZJ et al. Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. Tumor Biology 2014; 35: 1065-1073. http://dx. doi. org/10. 1007/s13277-013-1142-z.
14. QI P, DU X. The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine. Modern Pathology 2013; 26: 155-165. http://dx. doi. org/10. 1038/modpathol. 2012. 160.
15. TAKAHASHI Y, SAWADA G, KURASHIGE J, UCHI R, MATSUMURA T et al. Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. British Journal of Cancer 2014; 110: 164-171. http://dx. doi. org/10. 1038/bic. 2013. 698.
16. GUAN YH, KUO WL, STILWELL JL, TAKANO H, LAPUK AV et al. Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clinical Cancer Research 2007; 13: 5745-5755. http://dx. doi. org/10. 1158/1078-0432. CCR-06-2882.
17. DING J, LI D, GONG MZ, WANG JP, HUANG XR et al. Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer. Oncotargets and Therapy 2014; 7: 1625-1630. http://dx. doi. org/10. 2147/OTT. S68854.
18. RISUENO A, FONTANILLO C, DINGER ME, DE LAS RIVAS J. GATExplorer: Genomic and Transcriptomic Explorer; mapping expression probes to gene loci, transcripts, exons and ncRNAs. Bmc Bioinformatics 2010; 11.
19. PANG KC, STEPHEN S, DINGER ME, ENGSTROM PG, LENHARD B et al. RNAdb 2. 0-an expanded database of mammalian non-coding RNAs. Nucleic Acids Research 2007; 35: D178-D182. http://dx. doi. org/10. 1093/nar/gkl926.
20. DU Z, FEI T, VERHAAK RGW, SU Z, ZHANG Y, BROWN M et al. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nature Structural & Molecular Biology 2013; 20: 908. http://dx. doi. org/10. 1038/nsmb. 2591.
21. LI Q, SU ZJ, XU XY, LIU GF, SONG XH et al. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans. Proceedings of the National Academy of Sciences of the United States of America 2012; 109: 14110-14115. http://dx. doi. org/10. 1073/pnas. 1116597109.
22. PASSON DM, LEE M, RACKHAM O, STANLEY WA, SADOWSKA A et al. Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation. Proceedings of the National Academy of Sciences of the United States of America 2012; 109: 4846-4850. http://dx. doi. org/10. 1073/pnas. 1120792109.
23. SRIKANTAN V, ZOU Z, PETROVICS G, XU L, AUGUSTUS M et al. PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Proc Natl Acad Sci U S A 2000; 97: 12216-12221. http://dx. doi. org/10. 1073/pnas. 97. 22. 12216.
24. PRENSNER JR, SAHU A, IYER MK, MALIK R, CHANDLER B et al. The IncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer. Oncotarget 2014; 5: 1434-1438. http://dx. doi. org/10. 18632/oncotarget. 1846.
25. JI P, DIEDERICHS S, WANG W, BOING S, METZGER R et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 2003; 22: 8031-8041. http://dx. doi. org/10. 1038/si. onc. 1206928.
26. KIM K, JUTOORU I, CHADALAPAKA G, JOHNSON G, FRANK J et al. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 2013; 32: 1616-1625. http://dx. doi. org/10. 1038/onc. 2012. 193.
27. XU TP, HUANG MD, XIA R, LIU XX, SUN M et al. Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronec-tin1 expression. J Hematol Oncol 2014; 7: 63. http://dx. doi. org/10. 1186/s13045-014-0063-7.
28. SUN M, JIN FY, XIA R, KONG R, LI JH et al. Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer. BMC Cancer 2014; 14: 319. http://dx. doi. org/10. 1186/1471-2407-14-319.
29. SUN M, XIA R, JIN F, XU T, LIU Z et al. Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. Tumour Biol 2014; 35: 1065-1073. http://dx. doi. org/10. 1007/s13277-013-1142-z.
30. TSENG YY, MORIARITY BS, GONG WM, AKIYAMA R, TIWARI A et al. PVT1 dependence in cancer with MYC copy-number increase. Nature 2014; 512: 82. http://dx. doi. org/10. 1038/nature13311.
31. HAVERTY PM, HON LS, KAMINKER JS, CHANT J, ZHANG ZM. High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors. Bmc Medical Genomics 2009; 2.
32. WANG F, YUAN JH, WANG SB, YANG F, YUAN SX et al. Oncofetal Long Noncoding RNA PVT1 Promotes Pro liferation and Stem Cell-Like Property of Hepatocellular Carcinoma Cells by Stabilizing NOP2. Hepatology 2014; 60: 1278-1290. http://dx. doi. org/10. 1002/hep. 27239.
33. KONG R, ZHANG EB, YIN DD, YOU LH, XU TP et al. Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. Molecular Cancer 2015; 14. http://dx. doi. org/10. 1186/s12943-015-0355-8.