Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 26, Issue 10, 2016, Pages 931-936

  Lamri, A ^a,b,c   Bonnefond, A ^d,e,f   Meyre, D ^c   Balkau, B ^g   Roussel, R ^a,b,h   Marre, M ^a,b,h   Froguel, P ^d,e,f   Fumeron, F ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c MCMASTER UNIVERSITY   (Canada)

^d INSTITUT PASTEUR DE LILLE   (France)

^e UNIV LILLE   (France)

^f EGID FR3508 European Genomics Institute of Diabetes   (France)

^g CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^h BICHAT HOSPITAL   (France)

Author keywords

Dietary fat intake; Free fatty acid receptor 4 (FFAR4); G protein coupled receptor 120 (GPR120); Gene diet interaction; Longitudinal; Overweight; Type 2 diabetes (T2D)

Indexed keywords

ADULT; ARTICLE; DIETARY INTAKE; FEMALE; FOLLOW UP; FOOD FREQUENCY QUESTIONNAIRE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GPR120 GENE; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; ADVERSE EFFECTS; AGED; CALORIC INTAKE; DIABETES MELLITUS, TYPE 2; FAT INTAKE; FRANCE; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOTE; HOMOZYGOTE; INCIDENCE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHENOTYPE; RISK FACTOR; STATISTICAL MODEL; TIME FACTOR;

FAT INTAKE; G PROTEIN COUPLED RECEPTOR; O3FAR1 PROTEIN, HUMAN;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; DIETARY FATS; ENERGY INTAKE; FEMALE; FRANCE; GENE FREQUENCY; GENE-ENVIRONMENT INTERACTION; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INCIDENCE; LINEAR MODELS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; PHENOTYPE; PREVALENCE; PROSPECTIVE STUDIES; RECEPTORS, G-PROTEIN-COUPLED; RISK FACTORS; TIME FACTORS;

EID: 84969579660     PISSN: 09394753     EISSN: 15903729     Source Type: Journal    
DOI: 10.1016/j.numecd.2016.04.010     Document Type: Article

References (29)

1. [1] Ichimura, A., Hirasawa, A., Hara, T., Tsujimoto, G., Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostaglandins Other Lipid Mediat 89 (2009), 82–88.
2. [2] Rasmussen, S.G., DeVree, B.T., Zou, Y., Kruse, A.C., Chung, K.Y., Kobilka, T.S., et al. Crystal structure of the beta2 adrenergic receptor-Gs protein complex. Nature 477 (2011), 549–555.
3. [3] Ichimura, A., Hasegawa, S., Kasubuchi, M., Kimura, I., Free fatty acid receptors as therapeutic targets for the treatment of diabetes. Front Pharmacol, 5, 2014, 236.
4. [4] Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 11 (2005), 90–94.
5. [5] Ichimura, A., Hara, T., Hirasawa, A., Regulation of energy homeostasis via GPR120. Front Endocrinol, 5, 2014, 111.
6. [6] Matsumura, S., Mizushige, T., Yoneda, T., Iwanaga, T., Tsuzuki, S., Inoue, K., et al. GPR expression in the rat taste bud relating to fatty acid sensing. Biomed Res 28 (2007), 49–55.
7. [7] Matsumura, S., Eguchi, A., Mizushige, T., Kitabayashi, N., Tsuzuki, S., Inoue, K., et al. Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice. Neurosci Lett 450 (2009), 186–190.
8. [8] Cartoni, C., Yasumatsu, K., Ohkuri, T., Shigemura, N., Yoshida, R., Godinot, N., et al. Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci 30 (2010), 8376–8382.
9. [9] Iwasaki, K., Harada, N., Sasaki, K., Yamane, S., Iida, K., Suzuki, K., et al. Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K-cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion. Endocrinology 156 (2015), 837–846.
10. [10] Tanaka, T., Katsuma, S., Adachi, T., Koshimizu, T.A., Hirasawa, A., Tsujimoto, G., Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn Schmiedebergs Arch Pharmacol 377 (2008), 523–527.
11. [11] Engelstoft, M.S., Park, W.M., Sakata, I., Kristensen, L.V., Husted, A.S., Osborne-Lawrence, S., et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab 2 (2013), 376–392.
12. [12] Oh, D.Y., Talukdar, S., Bae, E.J., Imamura, T., Morinaga, H., Fan, W., et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142 (2010), 687–698.
13. [13] Gotoh, C., Hong, Y.H., Iga, T., Hishikawa, D., Suzuki, Y., Song, S.H., et al. The regulation of adipogenesis through GPR120. Biochem Biophys Res Commun 354 (2007), 591–597.
14. [14] Yore, M.M., Syed, I., Moraes-Vieira, P.M., Zhang, T., Herman, M.A., Homan, E.A., et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 159 (2014), 318–332.
15. [15] Morgan, N.G., Dhayal, S., G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem Pharmacol 78 (2009), 1419–1427.
16. [16] Moran, B.M., Abdel-Wahab, Y.H., Flatt, P.R., McKillop, A.M., Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic beta-cells. Diabetes Obes Metab 16 (2014), 1128–1139.
17. [17] Stone, V.M., Dhayal, S., Brocklehurst, K.J., Lenaghan, C., Sorhede Winzell, M., Hammar, M., et al. GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia 57 (2014), 1182–1191.
18. [18] Oh da, Y., Walenta, E., Akiyama, T.E., Lagakos, W.S., Lackey, D., Pessentheiner, A.R., et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med 20 (2014), 942–947.
19. [19] Ichimura, A., Hirasawa, A., Poulain-Godefroy, O., Bonnefond, A., Hara, T., Yengo, L., et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483 (2012), 350–354.
20. [20] Bonnefond, A., Lamri, A., Leloire, A., Vaillant, E., Roussel, R., Lévy-Marchal, C., et al. Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels. J Med Genet 52 (2015), 595–598.
21. [21] Balkau, B., An epidemiologic survey from a network of French Health Examination Centres, (D.E.S.I.R.): epidemiologic data on the insulin resistance syndrome. Rev Epidemiol Sante Publique 44 (1996), 373–375.
22. [22] Lasfargues, G., Vol, S., Le Clesiau, H., Bedouet, M., Hagel, L., Constans, T., et al. Validity of a short self-administered dietary questionnaire compared with a dietetic interview. Presse Med 19 (1990), 953–957.
23. [23] Cubeau, J., Pequignot, G., La technique du questionnaire alimentaire qualitatif utilisé par la section nutritionnelle de l'I.N.S.E.R.M. Rev Epidemiol Santé Publique 28 (1980), 367–372.
24. [24] Renaud, S., Godsey, F., Ortchanian, E., Baudier, F., Table de composition des aliments. 1982, Astra-Calve, Asnières.
25. [25] Burke, B.S., The dietary history as a tool in research. J Am Diet Assoc 23 (1947), 1041–1046.
26. [26] Expert Committee on the Diagnosis and, Classification of Diabetes Mellitus, Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26:Suppl. 1 (2003), S5–S20.
27. [27] Gauderman, W.J., Sample size requirements for matched case-control studies of gene-environment interaction. Statistics Med 21 (2002), 35–50.
28. [28] Lamri, A., Abi Khalil, C., Jaziri, R., Velho, G., Lantieri, O., Vol, S., et al. Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study. Int J Obes 36 (2012), 218–224.
29. [29] Sonestedt, E., Lyssenko, V., Ericson, U., Gullberg, B., Wirfalt, E., Groop, L., et al. Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort. J Clin Endocrinol Metab 97 (2012), E810–E818.