β-Glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid-resistant TH2/TH17 responses

Journal of Allergy and Clinical Immunology

Volumn 139, Issue 1, 2017, Pages 54-65.e8

  Zhang, Zhonghua ^a,b   Biagini Myers, Jocelyn M ^a,b   Brandt, Eric B ^a,b   Ryan, Patrick H ^a,b   Lindsey, Mark ^a,b   Mintz Cole, Rachael A ^a,b   Reponen, Tiina ^b   Vesper, Stephen J ^c   Forde, Frank ^a,b   Ruff, Brandy ^a,b   Bass, Stacey A ^a,b   LeMasters, Grace K ^a,b   Bernstein, David I ^b   Lockey, James ^b   Budelsky, Alison L ^d   Khurana Hershey, Gurjit K ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d AMGEN INC   (United States)

Author keywords

allergy; Childhood asthma; fungal exposure; fungi; house dust mite; IL 17A; glucan

Indexed keywords

BETA GLUCAN; CD4 ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 17; STEROID; AIR POLLUTANT; ALLERGEN; ANTIINFLAMMATORY AGENT; DECTIN 1; DEXAMETHASONE; GLUCOCORTICOID; HOUSE DUST ALLERGEN; IL17A PROTEIN, HUMAN; IL17RC PROTEIN, MOUSE; INTERLEUKIN RECEPTOR; LECTIN;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLUS VERSICOLOR; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG SENSITIVITY; EXPERIMENTAL ASTHMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; TH17 CELL; TH2 CELL; AIR POLLUTANT; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; BLOOD; C57BL MOUSE; CHILD; DRUG EFFECTS; DRUG RESISTANCE; ENVIRONMENTAL EXPOSURE; FUNGUS; GENETICS; IMMUNOLOGY; INFANT; KNOCKOUT MOUSE; LUNG; PATHOLOGY; PRESCHOOL CHILD; PREVALENCE;

AIR POLLUTANTS; ALLERGENS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; BETA-GLUCANS; CHILD; CHILD, PRESCHOOL; DEXAMETHASONE; DRUG RESISTANCE; ENVIRONMENTAL EXPOSURE; FEMALE; FUNGI; GLUCOCORTICOIDS; HUMANS; INFANT; INTERLEUKIN-17; LECTINS, C-TYPE; LUNG; MALE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PREVALENCE; RECEPTORS, INTERLEUKIN; TH17 CELLS; TH2 CELLS;

EID: 84969548801     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.02.031     Document Type: Article

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