Antifertility effects of crude ethanol extracts of tripterygium hypoglaucum (Levl.) hutch in male mongolian gerbils (meriones unguiculatus)

Journal of Applied Animal Research

Volumn 39, Issue 1, 2011, Pages 44-48

  Deng, Wang ^a   Yongwang, Guo ^b   Dazhao, Shi ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b National Agro Tech Extension and Service Center   (China)

Author keywords

Ethanol extracts; Male contraceptives; Mongolian gerbils (Meriones unguiculatus); Tripterygium hypoglaucum

Indexed keywords

EID: 84969443602     PISSN: 09712119     EISSN: 09741844     Source Type: Journal    
DOI: 10.1080/09712119.2011.570048     Document Type: Article

References (27)

1. Chen H, Lu WG, Chen JF, Xu Q, Chen GX, Liu QP. 2010. Influence of Tripterygium hypoglaucum Hutch on rat sperms evaluated by computer-assisted sperm analysis system. Journal Guangzhou University of Traditional Chinese Medicine 27:141-146. Chinese
2. Dehghani F, Panjehshahin MR, Mirzaee Z, Mehrabani D. 2005. Effect of Foeniculum vulgare organic extract on blood sex hormones and reproductive tissues of male rats. Journal of Applied Animal Research 27:17-20.
3. Huo XF, Wang D, Liang HC, Shi DZ, Zhang HQ, Liang JJ. 2006. A preliminary study on the anti-fertility effect of two sterilants to clawed birds (Meriones unguiculatus). Acta Agrestia Sinica 14:124-128. Chinese
4. Li XG, He L. 2006. Pharmacological control study between Tripterygium Hypoglaucum Hutch and Tripterygium Wilfordii. Journal of Kunming Medical College 2:107-110. Chinese
5. Lipsky PE, Tao XL. 1996. Inhibition of IL-2 production by Tripterygium wilfordii Hook F extract. US Patent 5500340.
6. Liu L, Wang ZY, Huang GZ, Liu Y. 2001. The influence of triptolide sub-chronic intoxication on kidney and testicle in mice. Acta Universitatis Medicine Tongji 30:214-217. Chinese
7. Lue Y, Sinha Hikim AP, Wang C, Leung A, Baravarian S, Reutrakul V, Sangswan R, Chaichana S, Swerdloff RS. 1998. Triptolide: a potential male contraceptive. Journal of Andrology 19:479-486.
8. Luo Z, Chen W, Gao W. 2000. Fauna Sinica. Mammalia. V. 6. Rodentia. Part III: cricetidae. Beijing (China): Science Press, p. 126-127. Chinese
9. Ma MF, Cai M, Li LB, Zeng WS, Li XS. 2000. Effects of Tripterygium Hypoglaucum (level) Hutch on the chromosome in human spermatozoa in vitro. Carcinogen, Teratogen Mutagen 12:90-92. Chinese
10. Sinha Hikim AP, Lue YH, Wang C, Reutrakul V, Sangsuwan R, Swerdloff RS. 2000. Posttesticular antifertility action of triptolide in the male rat: evidence for severe impairment of cauda epididymal sperm ultrastructure. Journal of Andrology 21:431-437.
11. Sun ZR, Liu Y. 2008. Pharmacognosy identification of ethno-medicine Tripterygium hypoglaucum Hutch. West China Journal of Pharmaceutical Sciences 23:174-175. Chinese
12. Umesiobi DO. 2010. Enhanced testicular development and fertilizing capacity of boars following sexual stimulation at different ages. Journal of Applied Animal Research 37:105-108.
13. Wang HC, Tai FD. 2003. Application and regulate mechanism of botanic sterilants for pest rodents reproduction. Journal of Shaanxi Normal University (Natural Science Edition; special edition) 31:208-213. Chinese
14. Wang SM, Wang Y, Zhang ZT, Lin N, Wu YL, Xu Y, Qian SZ. 1992. Studies on the reversibility of infertility caused by long-term administration of Tripterygium hypoglaucum (levl.) Hutch in male rats. Jiangsu Medical Journal 18:26-28. Chinese
15. WHO. 1983. A method for examining the effect of a plant extract administered orally on the fertility of male rats. WHO Protocol MB-50. APF/IP.99/4E.
16. WHO. 2001. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. Beijing (China): People’s Medical Publisher, p. 5-14.
17. Xu YP, Zhang HW, Xiao FH, Wang C, Zhao L. 2007. A study of effectiveness and safeness of the antifertility action of triptolide in rats. Herald of Medicine 26: 594-596. Chinese
18. Yang F, Dong XG, An ZM, Wu GQ, Zhang LJ, Gong NB, Gu TN. 2005. Retrospect and prospect of studies on Tripterygium wilfordii Hook f. Chinese Journal of Integrative Medicine (English Edition) 11:89-96.
19. Yu DY. 1983. Clinical observation of 144 cases of rheumatoid arthritis treated with glycoside of radix Tripterygium wilfordii. Journal of Traditional Chinese Medicine (English edition) 3:125-129.
20. Zeng HB, Chang W. 2005. Effect of colquhoumia root on the expression of transforming growth factor-b in mesangial proliferation glomerulonephritis model. Journal of Huazhong University of Science and Technology (Medical Sciences) 25:412-415.
21. Zha SW, Zha J, Huang YF. 2008. Male antifertility drugs and cell apoptosis. National Journal of Andrology 14:75-78. Chinese
22. Zhang B. 2002. Male antifertility effects of Multiglycosides of Tripterygium wilfordii (GTW). China Journal of Modern Medicine 12:16-17. Chinese
23. Zhang CM, Chen R, Zhou WM. 2001. Advance in the study of sterilants against rodents in China. Forest Pest and Disease 25:32-34. Chinese
24. Zhang ZB, Liao LF, Wang SQ, Cao XP, Wang FS, Wang C, Zhang JX, Wan XR, Zhong WQ. 2004. Effect of a contraceptive compound (EP-1) on fertility of female Brandt’s voles, gray hamsters and mid-day gerbils. Acta Zoologica Sinica 50:341-347. Chinese
25. Zhang LL, Shi DZ, Wang D. 2009. Effect of different sterility rates on Brandt’s vole population. Acta Agrestia Sinica 17:830-833. Chinese
26. Zhang JW, Xu Y, Qian SZ. 1996. Male antifertility compounds isolated from Triperygium Wilfordii. Acto Andrologica Sinica 2:81-84. Chinese
27. Zhang ZB, Wang SQ, Hao SS, Wang FS, Cao XP. 1997. The sterile effect of alpha-chlorohydrin on cricetulus triton. Acta Zoologica Sinica 17:232-233. Chinese.