Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients

Journal of the American Heart Association

Volumn 4, Issue 8, 2015, Pages

  Liu, Yuhong ^a   Xie, An ^a   Singh, Arun K ^a   Ehsan, Afshin ^a   Choudhary, Gaurav ^b   Dudley, Samuel ^a   Sellke, Frank W ^a   Feng, Jun ^a  

^a RHODE ISLAND HOSPITAL   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Coronary microcirculation; Coronary microvascular function; Diabetes mellitus; Potassium channels; Vascular endothelial function

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEMOGLOBIN A1C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; VASODILATOR AGENT; BIOLOGICAL MARKER; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

AGED; ARTERIAL TISSUE; ARTERIOLE; ARTERY DISSECTION; ARTICLE; BLOOD VESSEL REACTIVITY; CARDIAC MUSCLE; CELL MEMBRANE POTENTIAL; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DIABETIC PATIENT; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; HYPERPOLARIZATION; HYPERTENSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MICROCIRCULATION; MICROVASCULATURE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; VASCULAR ENDOTHELIUM; VASODILATATION; WESTERN BLOTTING; WHOLE CELL PATCH CLAMP; AGONISTS; BLOOD; CASE CONTROL STUDY; CELL CULTURE; CORONARY BLOOD VESSEL; DIABETIC ANGIOPATHIES; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECTS; MEMBRANE POTENTIAL; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ARTERIOLES; BIOMARKERS; CASE-CONTROL STUDIES; CELLS, CULTURED; CORONARY ARTERY DISEASE; CORONARY VESSELS; DIABETIC ANGIOPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTHELIAL CELLS; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MEMBRANE POTENTIALS; MIDDLE AGED; SIGNAL TRANSDUCTION; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; VASODILATION; VASODILATOR AGENTS;

EID: 84969379188     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002062     Document Type: Article

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