Substituted pyrazoles as p38 kinase inhibitors

Expert Opinion on Therapeutic Patents

Volumn 9, Issue 7, 1999, Pages 975-979

[No Author Info available]

Author keywords

anti inflammatory; cytokine; p38; pyrazole; tumour necrosis factor

Indexed keywords

EID: 84969296646     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.9.7.975     Document Type: Article

References (5)

1. HAN J, LEE JD, BIBBS L et al.: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science (1994) 265: 808–811.
2. LEE JC, LAYDON JT, MCDONNELL PC et al.: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature (1994) 372: 739–746.
3. GALLAGHER TF, FIER-THOMPSON SM, GARIGIPATI RS et2,4,5-Triarylimidazole inhibitors of IL-1 biosyn- thesis. Bioorg. Med. Chem. Lett. (1995) 5: 1171–1176.
4. DE LASZLO SE, VISCO D, AGARWAL L et al.: Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg. Med. Chem. Lett. (1998) 8: 2689–2694.
5. HENRY JR, RUPERT KC, DODD JH et al.: 6-Amino-2-(4-fluoropheny1)-4-methoxy-3-(4-pyridy1)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): a potent and selective p38 kinase inhibitor. J. Med. Chem. (1998) 41: 4196–4198.