Complement-mediated 'bystander' damage initiates host NLRP3 inflammasome activation

Journal of Cell Science

Volumn 129, Issue 9, 2016, Pages 1928-1939

  Suresh, Rahul ^a   Chandrasekaran, Prabha ^a   Sutterwala, Fayyaz S ^b   Mosser, David M ^a  

^a Bldg 142   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

ASC; Bystander activation; Caspase; Complement; IL 18; IL 1 ; Inflammasome; Membrane attack complex; NLRP3; Phagocytosis; TH17

Indexed keywords

COMPLEMENT; COMPLEMENT MEMBRANE ATTACK COMPLEX; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; APOPTOSIS REGULATORY PROTEIN; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; IL1B PROTEIN, MOUSE; NLRP3 PROTEIN, MOUSE; PYCARD PROTEIN, MOUSE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BYSTANDER EFFECT; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; HELPER CELL; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; TH17 CELL; ANIMAL; BAGG ALBINO MOUSE; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BYSTANDER EFFECT; COMPLEMENT C3A; COMPLEMENT C5A; COMPLEMENT MEMBRANE ATTACK COMPLEX; HEK293 CELLS; HUMANS; INTERLEUKIN-18; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PHAGOCYTOSIS; TH17 CELLS;

EID: 84968813349     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.179291     Document Type: Article

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