Effect of macitentan on the development of new ischemic digital ulcers in patients with systemic sclerosis: Dual-1 and Dual-2 randomized clinical trials

JAMA - Journal of the American Medical Association

Volumn 315, Issue 18, 2016, Pages 1975-1988

  Khanna, Dinesh ^a   Denton, Christopher P ^b   Merkel, Peter A ^c   Krieg, Thomas M ^d   Le Brun, Franck Olivier ^e   Marr, Angelina ^e   Papadakis, Kelly ^e   Pope, Janet ^f,s   Matucci Cerinic, Marco ^g   Furst, Daniel E ^h   Zochling, Jane ⁱ   Stevens, Wendy ^j   Proudman, Susanna ^k   Feenstra, John ^l   Youssef, Peter ^m   Soroka, Nikolay ⁿ   Tyabut, Tamara ^o   Mikhailova, Elena Ivanovna ^p   Rashkov, Rasho ^q   Batalov, Anastas ^q   Yablanski, Kiril ^q   Keystone, Edward ^r   Jones, Niall ^t   Dunne, James ^u   Masetto, Ariel ^v   Calabresse, Renato Jiménez ^w   Cabezas, Pedro Claudio Miranda ^x   Silva, Marta Ofelia Aliste ^y   Sariego, Imgadt Annelise Goecke ^z   Escalente, William José Otero ^aa   Anić, Branimir ^ab   Kaliterna, Dušanka Martinović ^ac   Morović Vergles, Jadranka ^ad   Novak, Srdan ^ae   Prus, Višnja ^af   Artuković, Marinko ^ag   Soukup, Tomaáš ^ah   Bečvař, Radim ^ai   Fojtík, Zdeněk ^aj   Mouthon, Luc ^ak   Kollert, Florian ^al   Riemekasten, Gabriela ^am   Lahner, Nina ^an   Fierlbeck, Gerhard ^ao   Ahmadi Simab, Keihan ^ap   Diehm, Curt ^aq   Szücs, Gabriella ^ar   Kumánovics, Gábor ^as   Nagy, György ^at   Pal, Sarvajeet ^au   Veeravalli, Sarath Chandra Mouli ^av   Danda, Debashish ^aw   Ferri, Clodeveo ^ax   Cozzi, Franco ^ay   Ferraccioli, Gianfranco ^az   Wiland, Piotr ^ba   Rudnicak, Lidia ^bb   Zwolak, Robert ^bc   Roszkiewicz, Jadwiga ^bd   Oleynikov, Valentin ^be   Nikulenkova, Natalya ^bf   Lesnyak, Olga ^bg   Kaidashev, Igor ^bh   Kurytar, Oleksandr ^bi   Piura, Olena ^bj   Chopyak, Valentyna ^bk   Chatterjee, Soumya ^bl   Hsu, Vivien ^bm   Hummers, Laura ^bn   Martin, Richard ^bo   Domsic, Robyn ^bp   Schiopu, Elena ^a   Shanahan, Joseph ^bq   Murphy, Frederik T ^br   Kaine, Jeffrey ^bs   Davis, William ^bt   Grau, Rafael ^bu   Eimon, Alicia ^bv   Catoggio, Luis Jose ^bw   Laborde, Hugo Armando ^bx   Caeiro, Francisco ^by   Savio, Veronica Gabriela ^bw   Amitrano, Cristina Beatriz ^bz   Vanthuyne, Marie ^ca   Zeng, Xioafeng ^cb   Zhang, Xiao ^cc   Zhu, Ping ^cd   Velásquez Franco, Carlos Jaime ^ce   Choueka, Philippe Selim Chalem ^cf   Sanchez, Patricia Julieta Vélez ^cg   Hermann, Walter ^ch   Sticherling, Michael ^ci   Steinbrink, Kerstin ^cj   Hein, Rüdiger ^ck   Aschoff, Roland ^cl   Sfikakis, Petros ^cm   Settas, Lukas ^cn   Fraser, Alexander ^co   Veale, Douglas ^cp   Balbir Gurman, Alexandra ^cq   Lidar, Merav ^cr   Litinsky, Irena ^cs   Levy, Yair ^ct   Carrillo Vazquez, Sandra Miriam ^cu   Rodriguez Reyna, Tatiana ^cv   Medrano Ramirez, Gabriel ^cw   Morales Torres, Jorge ^cx   Pacheco Tena, Cesar Francisco ^cy   Sanchez Ortiz, Adriana ^cz   Vonk, Madelon C ^da   Stebbings, Simon ^db   Solanki, Kamal ^dc   Steele, Richard ^dd   Ng, Kristine ^de   Zubrzycka Sienkiewicz, Anna ^df   Brzosko, Marek ^dg   Szepietowski, Jacek C ^dh   Hrycaj, Pawel ^di   Da Silva, Ivone Fernandes Santos ^dj   Dos Santos, Lelita Da Conceiçao ^dk   Coelho, Paulo Jorge Clemente ^dl   Rios, Grissel ^dm   Chernykh, Tatiana ^dn   Grunina, Elena ^do   Stanislav, Marina ^dp   Ally, Mahmood ^dq   Kalla, Asgar ^dr   Birlik, Ahmet Merih ^ds   Kovalenko, Volodymyr ^dt   Petrov, Andriy ^du   Shevchuk, Sergiy ^dv   Stanislavchuk, Mykola ^dw   Anderson, Marina ^dx   Herrick, Ariane ^dy   Belch, Jill ^dz   Chung, Lorinda ^ea   Csuka, Mary Ellen ^eb   Frech, Tracy ^ec   Goldberg, Avram ^ed   Kahaleh, Bashar ^ee   Mayes, Maureen D ^ef   Rothfield, Naomi ^eg   Simms, Robert William ^eh   Spiera, Robert ^ei   Steen, Virgina ^ej   Varga, John ^ek   Sikes, David ^el   Derk, Chris T ^em   Kohen, Michael D ^em   more..

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF COLOGNE   (Germany)

^e ACTELION PHARMACEUTICALS LTD   (Switzerland)

^f UNIVERSITY OF WESTERN ONTARIO   (Canada)

^g UNIVERSITY OF FLORENCE   (Italy)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF TASMANIA   (Australia)

^j ST VINCENT S HOSPITAL   (Australia)

^k ROYAL ADELAIDE HOSPITAL   (Australia)

^l WESLEY HOSPITAL   (Australia)

^m ROYAL PRINCE ALFRED HOSPITAL   (Australia)

ⁿ Maternity Hospital of Minsk Region   (Belarus)

^o Department of Anesthesiology   (Belarus)

^p Gomel Regional Clinical Hospital   (Belarus)

^q MHAT 'Sv Ivan Rilski' EAD Sofia ^*  (Bulgaria)

^r MOUNT SINAI HOSPITAL   (Canada)

^s ST JOSEPH S HEALTH CENTRE   (Canada)

^t Rheumatology Associates   (Canada)

^u ST PAUL S HOSPITAL   (Canada)

^v CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

^w Centro de Estudios Clinicos V   (Chile)

^x Centro de Estudios Reumatologicos   (Chile)

^y Office Marta Aliste Silva   (Chile)

^z Prosalud   (Chile)

^aa Servimed EU   (Colombia)

^ab KBC Zagreb   (Croatia)

^ac UNIVERSITY HOSPITAL SPLIT   (Croatia)

^ad University of Zagreb   (Croatia)

^ae KBC RIJEKA   (Croatia)

^af UNIVERSITY HOSPITAL OSIJEK   (Croatia)

^ag Klini ki Bolnica Sveti Duh   (Croatia)

^ah UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^ai INSTITUTE OF RHEUMATOLOGY   (Czech Republic)

^aj UNIVERSITY HOSPITAL BRNO   (Czech Republic)

^ak Institut Cochin   (France)

^al UNIVERSITY OF FREIBURG   (Germany)

^am CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^an RUHR UNIVERSITY BOCHUM   (Germany)

^ao UNIVERSITY OF TÜBINGEN   (Germany)

^ap ASKLEPIOS KLINIK ALTONA   (Germany)

^aq Akademie fur Gefasskrankheiten   (Germany)

^ar UNIVERSITY OF DEBRECEN   (Hungary)

^as UNIVERSITY OF PÉCS   (Hungary)

^at Debreceni Egyetem Klinikai Kozpont ^*  (Hungary)

^au Advance Rheumatology Clinic   (India)

^av KRISHNA INSTITUTE OF MEDICAL SCIENCES   (India)

^aw CHRISTIAN MEDICAL COLLEGE   (India)

^ax UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^ay UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^az School of Medicine   (Italy)

^ba Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu   (Poland)

^bb Centralny Szpital Kliniczny AM   (Poland)

^bc NZOZ Center for Medical Genetics   (Poland)

^bd Uniwersyteckie Centrum Kliniczne   (Poland)

^be Penza Regional Clinical Hospital   (Russian Federation)

^bf Regional Clinical Hospital   (Russian Federation)

^bg Regional Clinical Hospital   (Russian Federation)

^bh UKRAINIAN MEDICAL STOMATOLOGICAL ACADEMY   (Ukraine)

^bi Dnipropetrovsk Regional Clinicl Hospital   (Ukraine)

^bj Kyiv Clinic Hospital No3   (Ukraine)

^bk Lviv Regional Clinical Hospital   (Ukraine)

^bl LERNER RESEARCH INSTITUTE   (United States)

^bm UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^bn JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bo MICHIGAN STATE UNIVERSITY   (United States)

^bp UNIVERSITY OF PITTSBURGH   (United States)

^bq Shanahan Rheumatology and Immunotherapy   (United States)

^br Altoona Center for Clinical Research   (United States)

^bs Sarasota Arthritis Research Center   (United States)

^bt OCHSNER MEDICAL CENTER   (United States)

^bu UNIVERSITY OF ARIZONA   (United States)

^bv CEMIC   (Argentina)

^bw HOSPITAL ITALIANO DE BUENOS AIRES   (Argentina)

^bx Clinica del Tórax   (Argentina)

^by HOSPITAL PRIVADO   (Argentina)

^bz Sanatoria San Jose   (Argentina)

^ca CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^cb PEKING UNION MEDICAL COLLEGE   (China)

^cc GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^cd FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^ce Clinica Universitaria Bolivariana   (Colombia)

^cf Fundacion Instituto de Reumatologia   (Colombia)

^cg Centro Integral de Reumatologia e Inmunologia   (Colombia)

^ch KERCKHOFF HEART CENTER   (Germany)

^ci UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^cj JOHANNES GUTENBERG UNIVERSITY   (Germany)

^ck TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^cl DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^cm General National Hospital   (Greece)

^cn Cardiology Department   (Greece)

^co UNIVERSITY HOSPITAL LIMERICK   (Ireland)

^cp ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^cq TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^cr SHEBA MEDICAL CENTER   (Israel)

^cs TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^ct MEIR MEDICAL CENTER   (Israel)

^cu Hospital Angeles   (Mexico)

^cv INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^cw Clinica Diagnostico y Tratamiento de las Enfermedades Reumaticas   (Mexico)

^cx Morale Vargas Centro de Investigacion Leon   (Mexico)

^cy Investigacion y Biomedicina de Chihuahua   (Mexico)

^cz Unidad de Artritis y Reumatismo   (Mexico)

^da RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^db DUNEDIN HOSPITAL   (New Zealand)

^dc WAIKATO HOSPITAL   (New Zealand)

^dd WELLINGTON HOSPITAL   (New Zealand)

^de NORTH SHORE HOSPITAL   (New Zealand)

^df NZOZ Centrum Medyczne   (Poland)

^dg POMERANIAN MEDICAL UNIVERSITY   (Poland)

^dh SPSK Nr 1 Wroc aw   (Poland)

^di Prywatna Praktyka Weterynaryjna   (Poland)

^dj HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^dk CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^dl INSTITUTO PORTUGUÊS DE REUMATOLOGIA   (Portugal)

^dm UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^dn VORONEZH STATE MEDICAL UNIVERSITY NAMED AFTER N N BURDENKO   (Russian Federation)

^do City Clinical Hospital No12   (Russian Federation)

^dp V A NASONOVA RESEARCH INSTITUTE OF RHEUMATOLOGY   (Russian Federation)

^dq Syeve Biko Hospital   (South Africa)

^dr UNIVERSITY OF CAPE TOWN   (South Africa)

^ds DOKUZ EYLUL UNIVERSITY   (Turkey)

^dt Institute for Agricultural Engineering and Electrification   (Ukraine)

^du Crimean Republican Institution   (Ukraine)

^dv NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY   (Ukraine)

^dw Vinnytsia Regional Clinical Hospital   (Ukraine)

^dx UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

^dy SALFORD ROYAL NHS FOUNDATION TRUST   (United Kingdom)

^dz UNIVERSITY OF DUNDEE   (United Kingdom)

^ea STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^eb MEDICAL COLLEGE OF WISCONSIN   (United States)

^ec UNIVERSITY OF UTAH   (United States)

^ed Northwell Health   (United States)

^ee UNIVERSITY OF TOLEDO MEDICAL CENTER   (United States)

^ef UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^eg UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^eh BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ei HOSPITAL FOR SPECIAL SURGERY   (United States)

^ej GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^ek NORTHWESTERN UNIVERSITY   (United States)

^el Florida Medical Clinic   (United States)

^em Millennium Research   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MACITENTAN; PLACEBO; ENDOTHELIN 1; PYRIMIDINE DERIVATIVE; SULFONAMIDE;

ADULT; ANEMIA; ARTICLE; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FINGER ULCER; HAND FUNCTION; HEADACHE; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PERIPHERAL EDEMA; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SIDE EFFECT; SKIN ULCER; SYSTEMIC SCLEROSIS; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL; COMPLICATION; FINGER; MIDDLE AGED; ORAL DRUG ADMINISTRATION; OUTCOME ASSESSMENT;

ADMINISTRATION, ORAL; DOUBLE-BLIND METHOD; ENDOTHELIN-1; FEMALE; FINGERS; HUMANS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PYRIMIDINES; SCLERODERMA, SYSTEMIC; SKIN ULCER; SULFONAMIDES;

EID: 84968808222     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2016.5258     Document Type: Article

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