Financial Toxicity of Cancer Care: It's Time to Intervene

Journal of the National Cancer Institute

Volumn 108, Issue 5, 2016, Pages

  Zafar, S Yousuf ^a  

^a DUKE CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; IMATINIB;

BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER HORMONE THERAPY; CANCER MORTALITY; CANCER PATIENT; CANCER RESEARCH; CANCER SURVIVAL; CANCER THERAPY; CHRONIC MYELOID LEUKEMIA; COLORECTAL CANCER; DRUG COST; DRUG SAFETY; FINANCIAL MANAGEMENT; HEALTH CARE COST; HEALTH CARE POLICY; HEALTH CARE QUALITY; HEALTH INSURANCE; HEALTH LITERACY; HUMAN; MEDICAID; MEDICARE; METASTATIC COLORECTAL CANCER; NOTE; ONCOLOGIST; PHARMACIST; PRIORITY JOURNAL; QUALITY OF LIFE; TOXOPLASMOSIS; TREATMENT OUTCOME; COST BENEFIT ANALYSIS; ECONOMICS; EPIDEMIOLOGY; ETIOLOGY; INSURANCE; INTERPERSONAL COMMUNICATION; MENTAL STRESS; MORTALITY; NEOPLASMS; TRENDS; UNITED STATES;

COMMUNICATION; COST-BENEFIT ANALYSIS; HEALTH CARE COSTS; HEALTH EXPENDITURES; HEALTH LITERACY; HUMANS; INSURANCE COVERAGE; INSURANCE, HEALTH; MEDICARE; NEOPLASMS; QUALITY OF LIFE; STRESS, PSYCHOLOGICAL; UNITED STATES;

EID: 84968779648     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djv370     Document Type: Note

References (43)

1. Zafar SY, Peppercorn JM, Schrag D, et al. The Financial Toxicity of Cancer Treatment: A Pilot Study Assessing Out-of-Pocket Expenses and the Insured Cancer Patient's Experience. Oncologist. 2013;18(4):381-390.
2. Cohen RA, Gindi RM, Kirzinger WK. Burden of medical care cost: Early release of estimates from the National Health Interview Survey, January-June 2011. http://www.cdc.gov/nchs/nhis/releases.htm. Accessed November 20, 2015.
3. Bernard DSM, Farr SL, Fang Z. National Estimates of Out-of-Pocket Health Care Expenditure Burdens Among Nonelderly Adults With Cancer: 2001 to 2008. J Clin Oncol. 2011;29(20):2821-2826.
4. Davidoff AJ, Erten M, Shaffer T, et al. Out-of-pocket health care expenditure burden for medicare beneficiaries with cancer. Cancer. 2012;119(6):1257-1265.
5. Claxton G, Rae M, Panchal N. Consumer Assets and Patient Cost Sharing. http://kff.org/health-costs/issue-brief/consumer-assets-and-patient-costsharing/. Accessed November 20, 2015.
6. Bansal A, Ramsey SD, Fedorenko CR, et al. Financial insolvency as a risk factor for mortality among patients with cancer. In. American Society of Clinical Oncology Annual Meeting. Chicago, IL; 2015.
7. Tucker-Seeley RD, Li Y, Subramanian SV, et al. Financial Hardship and Mortality among Older Adults Using the 1996-2004 Health and Retirement Study. Ann Epidemiol. 2009;19(12):850-857.
8. Camfield L, Skevington SM. On subjective well-being and quality of life. J Health Psychol. 2008;13(6):764-775.
9. Hanratty B, Holland P, Jacoby A, et al. Financial stress and strain associated with terminal cancer - a review of the evidence. Palliat Med. 2007;21(7):595-607.
10. Markman M, Luce R. Impact of the cost of cancer treatment: an internet-based survey. J Oncol Pract. 2010;6(2):69-73.
11. Shankaran V, Jolly S, Blough D, et al. Risk Factors for Financial Hardship in Patients Receiving Adjuvant Chemotherapy for Colon Cancer: A Population- Based Exploratory Analysis. J Clin Oncol. 2012;30(14):1608-1614.
12. Cancer Support Community. Elevating the Patient Voice: Cancer experience registry index report 2013-2014. http://www.cancersupportcommunity.org/MainMenu/ResearchTraining/Elevating-the-Patient-Voice.pdf. Accessed November 20, 2015.
13. Lamers SMA, Bolier L, Westerhof GJ, et al. The impact of emotional wellbeing on long-term recovery and survival in physical illness: a meta-analysis. J Behav Med. 2012;35(5):538-547.
14. Frey BS. Happy People Live Longer. Science. 2011;331(6017):542-543.
15. Wilson IB, Cleary PD. Linking clinical variables with health-related quality of life: A conceptual model of patient outcomes. JAMA. 1995;273(1):59-65.
16. Fenn KM, Evans SB, McCorkle R, et al. Impact of Financial Burden of Cancer on Survivors' Quality of Life. J Oncol Pract. 2014; In press.
17. Catalano PJ, Ayanian JZ, Weeks JC, et al. Representativeness of participants in the cancer care outcomes research and surveillance consortium relative to the surveillance, epidemiology, and end results program. Med Care. 2013;51(2):e9-e15.
18. Zafar SY, McNeil RB, Thomas CM, et al. Population-Based Assessment of Cancer Survivors' Financial Burden and Quality of Life: A Prospective Cohort Study. J Oncol Pract. 2015;11(2):145-150.
19. Efficace F, Innominato PF, Bjarnason G, et al. Validation of patient's self-reported social functioning as an independent prognostic factor for survival in metastatic colorectal cancer patients: results of an international study by the Chronotherapy Group of the European Organisation for Research and Treatment of Cancer. J Clin Oncol. 2008;26(12):2020-2026.
20. Movsas B, Moughan J, Sarna L, et al. Quality of life supersedes the classic prognosticators for long-term survival in locally advanced non-small-cell lung cancer: an analysis of RTOG 9801. J Clin Oncol. 2009;27(34):5816-5822.
21. Bach PB. Limits on Medicare's Ability to Control Rising Spending on Cancer Drugs. New Engl J Med. 2009;360(6):626-633.
22. Neugut AI, Subar M, Wilde ET, et al. Association Between Prescription Co-Payment Amount and Compliance With Adjuvant Hormonal Therapy in Women With Early-Stage Breast Cancer. J Clin Oncol. 2011;29(18):2534-2542.
23. Hershman D, Shao T, Kushi L, et al. Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer. Breast Cancer Res Treat. 2011;126(2):529-537.
24. Dusetzina SB, Winn AN, Abel GA, et al. Cost Sharing and Adherence to Tyrosine Kinase Inhibitors for Patients With Chronic Myeloid Leukemia. J Clin Oncol. 2014;32(4):306-311.
25. Mailankody S, Prasad V. Five years of cancer drug approvals: Innovation, efficacy, and costs. JAMA Oncol. 2015;1(4):539-540.
26. Kantarjian HM, Fojo T, Mathisen M, et al. Cancer Drugs in the United States: Justum Pretium-The Just Price. J Clin Oncol. 2013;31(28):3600-3604.
27. Islam I. Rising Cost Of Drugs: Where Do We Go From Here? http://healthaffairs.org/blog/2015/08/31/rising-cost-of-drugs-where-do-we-go-from-here/. Accessed November 20, 2015.
28. Kaiser Family Foundation. 2014 Employer Health Benefits Survey. http://ehbs.kff.org/?page=charts&id=1&sn=8&ch=2676. Accessed November 20, 2015.
29. Chernew ME, Rosen AB, Fendrick AM. Value-Based Insurance Design. Health Affair. 2007;26(2):w195-w203.
30. Ramsey SD, Ganz PA, Shankaran V, et al. Addressing the American Health- Care Cost Crisis: Role of the Oncology Community. J Natl Cancer Inst. 2013;105(23):1777-1781.
31. Institute of Medicine. Delivering high-quality cancer care: Charting a new course for a system in crisis. http://www.nap.edu/catalog.php?record-id=18359. Accessed November 20, 2015.
32. Bach PB, Saltz LB, Wittes RE. In: Cancer Care, Cost Matters. New York Times; October 14, 2012.
33. Lorenzetti L. Doctors respond to Turing drug price hike: 'It's scare mongering'. http://fortune.com/2015/09/22/doctors-respond-to-turing-drug-pricehike-its-scare-mongering/. Accessed November 20, 2015.
34. Smith TJ, Hillner BE. Bending the Cost Curve in Cancer Care. New Engl J Med. 2011;364(21):2060-2065.
35. Neumann PJ, Palmer JA, Nadler E, et al. Cancer Therapy Costs Influence Treatment: A National Survey Of Oncologists. Health Affair. 2010;29(1):196-202.
36. Schrag D, Hanger M. Medical Oncologists' Views on Communicating With Patients About Chemotherapy Costs: A Pilot Survey. J Clin Oncol. 2007;25(2):233-237.
37. Bestvina CM, Zullig LL, Rushing C, et al. Patient-oncologist cost communication, financial distress, and medication adherence. J Oncol Pract. 2014;10(3):162-167.
38. Zafar SY, Chino F, Ubel PA, et al. The utility of cost discussions between cancer patients and oncologists. Am J Managed Care. 2015;21(9):607-615.
39. Schnipper LE, Davidson NE, Wollins DS, et al. American Society of Clinical Oncology Statement: A Conceptual Framework to Assess the Value of Cancer Treatment Options. J Clin Oncol. 2015;33(23):2563-2577.
40. Zafar SY, Ubel PA, Tulsky JA, Pollak KI. Cost-Related Health Literacy: A Key Component of High-Quality Cancer Care. J Oncol Pract. 2015;11(3):171-173.
41. Kutner M, Greenberg E, Jin Y, et al. The Health Literacy of America's Adults: Results From the 2003 National Assessment of Adult Literacy. In: Washington, DC: Department of Education, National Center For Education Statistics; 2006.
42. Barcellos SH, Wuppermann AC, Carman KG, et al. Preparedness of Americans for the Affordable Care Act. Proc Nat Acad Sci U S A. 2014;111(15):5497-5502.
43. Smith SK, Nicolla J, Zafar SY. Bridging the Gap Between Financial Distress and Available Resources for Patients With Cancer: A Qualitative Study. J Oncol Pract. 2014; In press.