Heavy metals, cardiovascular disease, and the unexpected benefits of chelation therapy

Journal of the American College of Cardiology

Volumn 67, Issue 20, 2016, Pages 2411-2418

  Lamas, Gervasio A ^a   Navas Acien, Ana ^b   Mark, Daniel B ^c   Lee, Kerry L ^c  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c DUKE CLINICAL RESEARCH INSTITUTE   (United States)

Author keywords

cadmium; coronary artery disease; lead; metal intoxication; myocardial infarction

Indexed keywords

ACETYLSALICYLIC ACID; ADVANCED GLYCATION END PRODUCT; CADMIUM; CLOPIDOGREL; EDETATE DISODIUM; HEAVY METAL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEAD; MINERAL; MULTIVITAMIN; PLACEBO; WARFARIN; CALCIUM CHELATING AGENT; EDETIC ACID;

ARTICLE; BIOACCUMULATION; CARDIOTOXICITY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHELATION THERAPY; CORONARY ARTERY ATHEROSCLEROSIS; DIABETES MELLITUS; ENVIRONMENTAL EXPOSURE; EXCRETION; HEART INFARCTION; HUMAN; HYPERTENSION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; ADVERSE EFFECTS; CARDIOVASCULAR DISEASES; CHEMICALLY INDUCED; DIABETIC COMPLICATION;

CALCIUM CHELATING AGENTS; CARDIOVASCULAR DISEASES; CHELATION THERAPY; DIABETES COMPLICATIONS; EDETIC ACID; ENVIRONMENTAL EXPOSURE; HUMANS; METALS, HEAVY; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84968610524     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2016.02.066     Document Type: Review

References (53)

1. Kaiser C. AHA: dismay greets positive chelation study. MedPage Today. November 4, 2012. Available at: http://www.medpagetoday.com/MeetingCoverage/AHA/35746. Accessed March 13, 2016.
2. G.A. Lamas, C. Goertz, R. Boineau, et al. for the TACT Investigators Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial JAMA 309 2013 1241 1250
3. J.S. Goodwin, and J.M. Goodwin The tomato effect. Rejection of highly efficacious therapies JAMA 251 1984 2387 2390
4. Münz F, inventor; General Aniline Works, Inc., assignee. Polyamino carboxylic acids and process for making same. US patent 2,130,505. September 20, 1938.
5. M. Rubin, S. Gignac, S.P. Bessman, and et al. Enhancement of lead excretion in humans by disodium calcium ethylene-diamine tetraacetate Science 117 1953 659 660
6. C.N. Clarke, N.E. Clarke, and R.E. Mosher Treatment of angina pectoris with disodium ethylene diamine tetraacetic acid Am J Med Sci 232 1956 654 666
7. H.I. Russek, B.L. Zohman, and V.J. Dorset Effects of tobacco and whiskey on the cardiovascular system J Am Med Assoc 157 1955 563 568
8. J.R. Kitchell, F. Palmon Jr., N. Aytan, and et al. The treatment of coronary artery disease with disodium EDTA. A reappraisal Am J Cardiol 11 1963 501 506
9. American Medical Association. Proceedings of the House of Delegates. Report of the Council on Scientific Affairs in regard to chelation therapy. December 2-5, 1984:272-4.
10. T.C. Rozema Special issue: protocols for chelation therapy J Adv Med 10 1997 5 90
11. C. Hancke, and K. Flytlie Benefits of EDTA chelation therapy in arteriosclerosis: a retrospective study of 470 patients J Adv Med 6 1993 161 171
12. T.C. Clarke, L.I. Black, B.J. Stussman, and et al. Trends in the complementary health approaches among adults: United States, 2002-2012 Natl Health Stat Report 79 2015 1 16
13. B. Guldager, R. Jelnes, S.J. Jørgensen, and et al. EDTA treatment of intermittent claudication - a double-blind, placebo-controlled study J Intern Med 231 1992 261 267
14. A.M. Van Rij, C. Solomon, S.G.K. Packer, and et al. Chelation therapy for intermittent claudication. A double-blind, randomized, controlled trial Circulation 90 1994 1194 1199
15. M.L. Knudtson, D.G. Wyse, P.D. Galbraith, et al. for the Program to Assess Alternative Treatment Strategies to Achieve Cardiac Health (PATCH) Investigators Chelation therapy for ischemic heart disease: a randomized controlled trial JAMA 287 2002 481 486
16. G.A. Lamas, and A. Ackermann Clinical evaluation of chelation therapy: is there any wheat amidst the chaff? Am Heart J 140 2000 4 5
17. G.A. Lamas, C. Goertz, R. Boineau, and et al. Design of the Trial to Assess Chelation Therapy (TACT) Am Heart J 163 2012 7 12
18. E. Escolar, G.A. Lamas, D.B. Mark, and et al. The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT) Circ Cardiovasc Qual Outcomes 7 2014 15 24
19. R.S. Waters, N.A. Bryden, K.Y. Patterson, and et al. EDTA chelation effects on urinary losses of cadmium, calcium, chromium, cobalt, copper, lead, magnesium, and zinc Biol Trace Elem Res 83 2001 207 221
20. I.A. Arenas, A. Navas-Acien, and G.A. Lamas Enhanced vasculotoxic metal excretionin post-MI patients after edetate disodium therapy (abstr) J Am Coll Cardiol 67 13 Suppl 2016 A2125
21. N.V. Solenkova, J.D. Newman, J.S. Berger, and et al. Metal pollutants and cardiovascular disease: mechanisms and consequences of exposure Am Heart J 168 2014 812 822
22. K.E. Cosselman, A. Navas-Acien, and J.D. Kaufman Environmental factors in cardiovascular disease Nat Rev Cardiol 12 2015 627 642
23. Agency for Toxic Substances & Disease Registry. Priority list of hazardous substances. 2016. Available at: http://www.atsdr.cdc.gov/SPL/index.html. Accessed March 13, 2016.
24. National Institutes of Health, Office of Extramural Research. Request for information (RFI): the impact of environmental lead exposure on cognition and bone function. 2015. Available at: http://grants.nih.gov/grants/guide/notice-files/NOT-TW-15-002.html. Accessed March 13, 2016.
25. National Research Council Committee on Lead in the Human Environment A Report Prepared by the Committee on Lead in the Human Environment, Environmental Studies Board, Commission on Natural Resources, National Research Council 1980 National Academy of Sciences Washington, DC
26. A. Apostolou, E. Garcia-Esquinas, J.J. Fadrowski, and et al. Secondhand tobacco smoke: a source of lead exposure in US children and adolescents Am J Public Health 102 2012 714 722
27. H. Hu, R. Shih, S. Rothenberg, and et al. The epidemiology of lead toxicity in adults: measuring dose and consideration of other methodologic issues Environ Health Perspect 115 2007 455 462
28. B.K. Lee, B.S. Schwartz, W. Stewart, and et al. Provocative chelation with DMSA and EDTA: evidence for differential access to lead storage sites Occup Environ Med 52 1995 13 19
29. A. Navas-Acien, E. Guallar, E.K. Silbergeld, and et al. Lead exposure and cardiovascular disease - a systematic review Environ Health Perspect 115 2007 472 482
30. P. Muntner, A. Menke, K.B. DeSalvo, and et al. Continued decline in blood lead levels among adults in the United States: the National Health and Nutrition Examination Surveys Arch Intern Med 165 2005 2155 2161
31. A. Navas-Acien, E. Selvin, A.R. Sharrett, and et al. Lead, cadmium, smoking, and increased risk of peripheral arterial disease Circulation 109 2004 3196 3201
32. M. Weisskopf, N. Jain, H. Nie, and et al. A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging Study Circulation 120 2009 1056 1064
33. A. Navas-Acien, B.S. Schwartz, S.J. Rothenberg, and et al. Bone lead levels and blood pressure endpoints: a meta-analysis Epidemiology 19 2008 496 504
34. N.D. Vaziri, and M. Khan Interplay of reactive oxygen species and nitric oxide in the pathogenesis of experimental lead-induced hypertension Clin Exp Pharmacol Physiol 34 2007 920 925
35. C.W. Hanna, M.S. Bloom, W.P. Robinson, and et al. DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF Hum Reprod 27 2012 1401 1410
36. S. Skerfving, and I.A. Bergdahl Lead G.F. Nordberg, B.A. Fowler, M. Nordberg, L.T. Friberg, Handbook on the Toxicology of Metals Third Edition 2007 Academic Press Cambridge, MA 599 643
37. M. Tellez-Plaza, A. Navas-Acien, K.L. Caldwell, and et al. Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking rates Environ Health Perspect 120 2012 204 209
38. Agency for Toxic Substances & Disease Registry (ATSDR). Toxicological profile for cadmium. 2012. Available at: http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=48&tid=15. Accessed March 13, 2016.
39. A. Menke, P. Muntner, E.K. Silbergeld, and et al. Cadmium levels in urine and mortality among U.S. adults Environ Health Perspect 117 2009 190 196
40. M. Tellez-Plaza, A. Navas-Acien, A. Menke, and et al. Cadmium exposure and all-cause and cardiovascular mortality in the U.S. general population Environ Health Perspect 120 2012 1017 1022
41. M. Tellez-Plaza, E. Guallar, R.R. Fabsitz, and et al. Cadmium exposure and incident peripheral arterial disease Circ Cardiovasc Qual Outcomes 6 2013 626 633
42. M. Tellez-Plaza, E. Guallar, B.V. Howard, and et al. Cadmium exposure and incident cardiovascular disease Epidemiology 24 2013 421 429
43. M. Tellez-Plaza, M.R. Jones, A. Dominguez-Lucas, and et al. Cadmium exposure and clinical cardiovascular disease: a systematic review Curr Atheroscler Rep 15 2013 356
44. B. Messner, M. Knoflach, A. Seubert, and et al. Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance Arterioscler Thromb Vasc Biol 29 2009 1392 1398
45. B. Messner, and D. Bernhard Cadmium and cardiovascular diseases: cell biology, pathophysiology, and epidemiological relevance Biometals 23 2010 811 822
46. E. Martin-Nuñez, J. Donate-Correa, M. Muros-de-Fuentes, and et al. Implications of Klotho in vascular health and disease World J Cardiol 6 2014 1262 1269
47. A. Ruiz-Hernandez, C.C. Kuo, P. Rentero-Garrido, and et al. Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence Clin Epigenetics 7 2015 55
48. M.B. Manigrasso, J. Juranek, R. Ramasamy, and et al. Unlocking the biology of RAGE in diabetic microvascular complications Trends Endocrinol Metab 25 2014 15 22
49. J.W. Baynes Role of oxidative stress in development of complications in diabetes Diabetes 40 1991 405 412
50. C.P. Hodgkinson, R.C. Laxton, K. Patel, and et al. Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis Arterioscler Thromb Vasc Biol 28 2008 2275 2281
51. S.Y. Goh, and M.E. Cooper The role of advanced glycation end products in progression and complications of diabetes J Clin Endocrinol Metab 93 2008 1143 1152
52. M. Qian, M. Liu, and J.W. Eaton Transition metals bind to glycated proteins forming redox active "glycochelates": implications for the pathogenesis of certain diabetic complications Biochem Biophys Res Commun 250 1998 385 389
53. N. Frizzell, and J.W. Baynes Chelation therapy: overlooked in the treatment and prevention of diabetes complications? Future Med Chem 5 2013 1075 1078