On a path to accelerate access to Ebola vaccines: The WHO's research and development efforts during the 2014-2016 Ebola epidemic in West Africa

Current Opinion in Virology

Volumn 17, Issue , 2016, Pages 138-144

  Henao Restrepo, Ana Maria ^a   Preziosi, Marie Pierre ^a   Wood, David ^a   Moorthy, Vasee ^a   Kieny, Marie Paule ^a  

^a WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EBOLA VACCINE;

AFRICA; ARTICLE; CLINICAL TRIAL (TOPIC); COMMUNITY CARE; EBOLA HEMORRHAGIC FEVER; EPIDEMIC; HEALTH CARE ACCESS; HEALTH CARE POLICY; HUMAN; INFECTION PREVENTION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PUBLIC HEALTH; STUDY DESIGN; WORLD HEALTH ORGANIZATION; DISEASE OUTBREAKS; DRUG DEVELOPMENT; EPIDEMICS; HEMORRHAGIC FEVER, EBOLA; INTERSECTORAL COLLABORATION; LEGISLATION AND JURISPRUDENCE; MEDICAL RESEARCH; PROCEDURES; STANDARDS; STATISTICS AND NUMERICAL DATA; VIROLOGY;

AFRICA, WESTERN; BIOMEDICAL RESEARCH; DISEASE OUTBREAKS; DRUG DISCOVERY; EBOLA VACCINES; EPIDEMICS; HEMORRHAGIC FEVER, EBOLA; HUMANS; INTERSECTORAL COLLABORATION; PUBLIC HEALTH; WORLD HEALTH ORGANIZATION;

EID: 84968584138     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2016.03.008     Document Type: Review

References (41)

1. World Health Organization Report of the Ebola Interim Assessment Panel 2015, July http://www.who.int/entity/csr/resources/publications/ebola/ebola-panel-report/en/index.html
2. S. Moon, D. Sridhar, M.A. Pate, A.K. Jha, and et al. Will Ebola change the game? Ten essential reforms before the next pandemic. The report of the Harvard-LSHTM Independent Panel on the Global Response to Ebola Lancet 28 2015 2204 2221 10.1016/S0140-6736(15)00946-0 [Epub 2015 Nov 23]
3. Wellcome Trust and the Center for Infectious Disease Research and Policy (CIDRAP) University of Minnesota. Recommendations for Accelerating the Development of Ebola Vaccines: Report & analysis 2015, February http://www.cidrap.umn.edu/sites/default/files/public/downloads/ebola-virus-team-b-report-final-021615.pdf
4. World Health Organization Categorization and prioritization of drugs for consideration for testing or use in patients infected with Ebola 2015, July http://www.who.int/medicines/ebola-treatment/2015-0703TablesofEbolaDrugs.pdf?ua=1
5. World Health Organization WHO Consultation on potential Ebola therapies and vaccines held by the World Health Organization 2014, September https://www.google.ch/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwiigbrj-NjKAhUFnA4KHUlSB7MQFggcMAA&url=http%3A%2F%2Fwww.who.int%2Fcsr%2Fresources%2Fpublications%2Febola%2Febola-therapies%2Fen%2F&usg=AFQjCNGLavMgAmQD8TYIaKHz5Xx-tvT1iw&sig2=LfPl5JNOlYpakUhy1ZAo-A
6. World Health Organization WHO high-level meeting on Ebola vaccines access and financing: Full Summary Report 2014, October http://apps.who.int/iris/bitstream/10665/137184/1/WHO-EVD-Meet-EMP-14.2-eng.pdf?ua=1
7. World Health Organization Second WHO High-level Meeting on Ebola Vaccines Access and Financing 2015, January http://www.who.int/entity/mediacentre/events/2015/ebola-vaccine-access/en/index.html
8. World Health Organization How Can Science Inform Our Response to Ebola Virus Disease? Note of a Consultation Held on 2014 2014, October http://www.who.int/medicines/ebola-treatment/meetings/2014-1007-Ebola-Science-Committee-First-TC-MeetingNote.pdf?ua=1
9. World Health Organization Meeting of the WHO Ebola Science Committee 2014, November http://www.who.int/entity/medicines/ebola-treatment/meetings/ebola-science-committee/en/index.html
10. World Health Organization Meeting of the WHO Ebola Science Committee 2015, March http://www.who.int/entity/medicines/ebola-treatment/meetings/science-committee-march/en/index.html
11. World Health Organization First Teleconference on Regulatory Approaches for Expediting Development and Availability of Ebola Vaccines 2014, October http://www.who.int/entity/medicines/ebola-treatment/meetings/2014-1030-1stT-RegEbola-vaccines-summary.pdf?ua=1
12. World Health Organization First Teleconference on Regulatory Approaches for Expediting Development and Availability of Ebola Vaccines 2015, January http://www.who.int/entity/medicines/ebola-treatment/meetings/2015-0127-2ndTC-RegEbola.pdf?ua=1
13. Ninth Annual Meeting of the African Vaccine Regulatory Forum (AVAREF), Pretoria South Africa 2014, November http://www.who.int/entity/medicines/ebolatreatment/meetings/phaseII-clinical-trial-meeting/en/index.html
14. World Health Organization Report of the Joint Review Meeting Facilitated by the World Health Organization for the GSK ChAd3 Ebola Vaccine Clinical Trials Application 2014 http://www.who.int/entity/immunization-standards/vaccine-regulation/2014-1217-BriefingAfricanNRA-EC.pdf?ua=1
15. World Health Organization Emergency Use Assessment and Listing Procedure (EUAL) for Candidate Vaccines for Use in the Context of a Public Health Emergency 2015, July http://www.who.int/medicines/news/EUAL-vaccines-7July2015-MS.pdf
16. World Health Organization Experimental Ebola Vaccines WHO Consultation on Ebola Vaccines: Ebola Situation Assessment 2014, October http://www.who.int/mediacentre/news/ebola/01-october-2014/en/
17. World Health Organization Ethical Issues Related to Study Design for Trials on Therapeutics for Ebola Virus Disease. WHO Ethics Working Group meeting 2014, October http://www.who.int/csr/resources/publications/ebola/ethical-evd-therapeutics/en/
18. World Health Organization First Teleconference on Vaccine Clinical Trials Design in Guinea Liberia and Sierra Leone 2014, October http://www.who.int/entity/medicines/ebola-treatment/2014-1028-Minutes-1stTC-on-vaccine-clinical-trials.pdf?ua=1
19. World Health Organization Second Teleconference on Vaccine Clinical Trials Design in Guinea Liberia and Sierra Leone 2014, November http://www.who.int/entity/medicines/ebola-treatment/2014-1125-Minutes-2ndTC-on-vaccine-clinical-trials.pdf?ua=1
20. World Health Organization Third Teleconference on Vaccine Clinical Trials Design in Guinea Liberia and Sierra Leone 2014, December http://www.who.int/entity/medicines/ebola-treatment/3rd-teleconference-vaccines.pdf?ua=1
21. World Health Organization Fourth Teleconference on Vaccine Clinical Trials Design in Guinea Liberia and Sierra Leone 2015, March http://www.who.int/entity/medicines/ebola-treatment/4th-teleconference-vaccine-clinical-trials.pdf?ua=1
22. World Health Organization Fifth Teleconference on Vaccine Clinical Trials Design in Guinea Liberia and Sierra Leone 2015, July http://www.who.int/entity/medicines/ebola-treatment/meetings/fifth-tel-conf-clinictrials/en/index.html
23. World Health Organization WHO Ebola Vaccine Target Product Profile 2015, January http://www.who.int/immunization/research/target-product-profile/ebolavaccine/en/
24. World Health Organization VSV Consortium Overview and key questions 2014 https://www.google.ch/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwiSzbzpkdnKAhVBfRoKHUAPDN0QFggcMAA&url=http%3A%2F%2Fwww.who.int%2Fimmunization%2Fdiseases%2Febola%2F3-rVSV-Phase-1-Michael-29-Sep-14-v2.pdf&usg=AFQjCNGUY1yV0nJkE5cuJhF2ppLN6F6YQw&sig2=-J6Ss7LLJ0Wvcuu2Dn6FSw&bvm=bv.113034660,d.d2s
25. S.T. Agnandji, A. Huttner, M.E. Zinser, P. Njuguna, and et al. Phase 1 trials of rVSV Ebola vaccine in Africa and Europe - Preliminary Report N Engl J Med April 2015
26. J.A. Regules, J.H. Beigel, K.M. Paolino, J. Voell, and et al. A recombinant vesicular stomatitis virus Ebola vaccine - preliminary report N Engl J Med April 2015
27. Ebola ça suffit ring vaccination trial consortium The ring vaccination trial: a novel cluster randomised controlled trial design to evaluate vaccine efficacy and effectiveness during outbreaks, with special reference to Ebola Br Med J 351 2015 h3740 http://www.bmj.com/content/351/bmj.h3740 (Published 27.07.15)
28. A.M. Henao-Restrepo, I.M. Longini, M. Egger, and et al. Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial Lancet 386 2015 p857 p866 http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)61117-5.pdf
29. World Health Organization Ebola ça suffit! - Phase III Vaccine Trial in Guinea: Questions and Answers 2016, January http://www.who.int/medicines/ebola-treatment/q-a-ebola-ca-suffit/en/
30. World Health Organization Meeting of the Strategic Advisory Group of Experts on immunization October 2015 - conclusions and recommendations Wkly Epidemiol Rec 90 2015 681 700 http://www.who.int/wer/2015/wer9050.pdf?ua=1. 90th YEAR/11. No. 50
31. World Health Organization Meeting of the Strategic Advisory Group of Experts on immunization, April 2015 - conclusions and recommendations Wkly Epidemiol Rec 90 2015 May 29 261 280 http://www.who.int/wer/2015/wer9022.pdf?ua=1. 90th YEAR/11. No. 22
32. World Health Organization First workshop of the partners group on Ebola vaccines deployment. Summary report 2015, February http://www.who.int/healthsystems/publications/vaccines-deployment-workshop/en/
33. World Health Organization Ebola R&D Landscape of clinical candidates and trials. Public report 2015, October http://www.who.int/medicines/ebola-treatment/EbolaR-D-public-report-updt2015.pdf
34. S.B. Kennedy, J.D. Neaton, H.C. Lane, and M.W.S. Kieh Implementation of an Ebola virus disease vaccine clinical trial during the Ebola epidemic in Liberia: design, procedures, and challenges Clin Trials January 2016 http://ctj.sagepub.com/content/early/2016/01/08/1740774515621037.long
35. United States Centers for Disease Control and Prevention (CDC) Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) Questions and Answers 2015, December http://www.cdc.gov/vhf/ebola/strive/qa.html
36. World Health Organization Ebola Virus Disease Outbreak and Issues Raised: Follow-up to the Special Session of the Executive Board on the Ebola Emergency (Resolution EBSS3.R1) and the Sixty-eighth World Health Assembly (Decision WHA68(10))Executive Board EB138/27 138th Session 22 January 2016 Provisional Agenda Item 9.1 2014 http://apps.who.int/gb/ebwha/pdf-files/EB138/B138-27-en.pdf
37. World Health Organization Special Session of the Executive Board on Ebola EBSS3.R1 Agenda Item 3 25 January 2015. Ebola: Ending the Current Outbreak, Strengthening Global Preparedness and Ensuring WHO's Capacity to Prepare for and Respond to Future Large-scale Outbreaks and Emergencies with Health Consequences 2015 http://apps.who.int/gb/ebwha/pdf-files/EBSS3/EBSS3-R1-en.pdf
38. World Health Organization WHO Ebola Research and Development Summit Geneva 2015, May http://www.who.int/medicines/ebola-treatment/Executive-summary-WHO-Ebola-RandD-summit.pdf?ua=1&ua=1
39. World Health Organization A Research and Development Blueprint for Action to Prevent Epidemics 2015 http://www.who.int/csr/research-and-development/en/
40. http://www.gavi.org/Library/News/Press-releases/2016/Ebola-vaccine-purchasing-commitment-from-Gavi-to-prepare-for-future-outbreaks/.
41. R. Kanapathipillai, A.M. Henao Restrepo, P. Fast, Ph.D. Wood, D. Dye, and C.V. Kieny MPand Moorthy Ebola vaccine - an urgent international priority N Engl J Med 371 2014 2249 2251