The effect of cangrelor and access site on ischaemic and bleeding events: Insights from CHAMPION PHOENIX

European Heart Journal

Volumn 37, Issue 14, 2016, Pages 1122-1130

  Gutierrez, J Antonio ^a   Harrington, Robert A ^b   Blankenship, James C ^c   Stone, Gregg W ^d   Steg, Ph Gabriel ^e,f   Gibson, C Michael ^g   Hamm, Christian W ^h   Price, Matthew J ⁱ   Généreux, Philippe ^d   Prats, Jayne ^j   Deliargyris, Efthymios N ^j   Mahaffey, Kenneth W ^b   White, Harvey D ^k   Bhatt, Deepak L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEISINGER MEDICAL CENTER   (United States)

^d NewYork Presbyterian Hospital   (United States)

^e INSERM   (France)

^f ROYAL BROMPTON HOSPITAL   (United Kingdom)

^g BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^h Kerckhoff Heart and Thorax Center   (Germany)

ⁱ SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE   (United States)

^j MEDICINES COMPANY   (United States)

^k Green Lane Cardiovascular Service ^*  (New Zealand)

more..

Author keywords

Percutaneous coronary intervention; Platelet inhibition; Radial artery

Indexed keywords

ACETYLSALICYLIC ACID; CANGRELOR; CLOPIDOGREL; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; ADENOSINE PHOSPHATE; ANTITHROMBOCYTIC AGENT; PURINERGIC P2Y RECEPTOR ANTAGONIST; TICLOPIDINE;

ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; BOLUS INJECTION; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG ELUTING STENT; DRUG SAFETY; FEMALE; FEMORAL ARTERY; FEMORAL PERCUTANEOUS CORONARY INTERVENTION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REVASCULARIZATION; HUMAN; INTERMETHOD COMPARISON; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RADIAL ARTERY; RADIAL PERCUTANEOUS CORONARY INTERVENTION; RANDOMIZED CONTROLLED TRIAL; STENT THROMBOSIS; TREATMENT OUTCOME; VASCULAR ACCESS; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; CHEMICALLY INDUCED; CLINICAL TRIAL; COMPARATIVE STUDY; CORONARY THROMBOSIS; GRAFT OCCLUSION, VASCULAR; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; MULTICENTER STUDY; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; PROCEDURES; STATISTICS AND NUMERICAL DATA; STENT;

ADENOSINE MONOPHOSPHATE; AGED; CORONARY THROMBOSIS; DOUBLE-BLIND METHOD; FEMALE; FEMORAL ARTERY; GRAFT OCCLUSION, VASCULAR; HEMORRHAGE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REVASCULARIZATION; PERCUTANEOUS CORONARY INTERVENTION; PLATELET AGGREGATION INHIBITORS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RADIAL ARTERY; STENTS; TICLOPIDINE; TREATMENT OUTCOME;

EID: 84966680024     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehv498     Document Type: Article

References (13)

1. Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, Kaul S, Wiviott SD, Menon V, Nikolsky E, Serebruany V, Valgimigli M, Vranckx P, Taggart D, Sabik JF, Cutlip DE, KrucoffMW, OhmanEM, Steg PG, WhiteH. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the BleedingAcademic Research Consortium. Circulation 2011;123:2736-2747.
2. Gutierrez A, Bhatt DL. Balancing the risks of stent thrombosis and major bleeding during primary percutaneous coronary intervention. Eur Heart J 2014;35: 2448-2451.
3. Jolly SS, Yusuf S, Cairns J, Niemela K, Xavier D, Widimsky P, Budaj A, Niemela M, Valentin V, Lewis BS, Avezum A, Steg PG, Rao SV, Gao P, Afzal R, Joyner CD, Chrolavicius S, Mehta SR, group Rt. Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial. Lancet 2011;377:1409-1420.
4. Romagnoli E, Biondi-Zoccai G, Sciahbasi A, Politi L, Rigattieri S, Pendenza G, Summaria F, Patrizi R, Borghi A, Di Russo C, Moretti C, Agostoni P, Loschiavo P, Lioy E, Sheiban I, Sangiorgi G. Radial versus femoral randomized investigation in ST-segment elevation acute coronary syndrome: the RIFLE-STEACS (Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome) study. J Am Coll Cardiol 2012;60:2481-2489.
5. Valgimigli M, Gagnor A, Calabro P, Frigoli E, Leonardi S, Zaro T, Rubartelli P, Briguori C, Ando G, Repetto A, Limbruno U, Cortese B, Sganzerla P, Lupi A, Galli M, Colangelo S, Ierna S, Ausiello A, Presbitero P, Sardella G, Varbella F, Esposito G, Santarelli A, Tresoldi S, Nazzaro M, Zingarelli A, de Cesare N, Rigattieri S, Tosi P, Palmieri C, Brugaletta S, Rao SV, Heg D, Rothenbuhler M, Vranckx P, Juni P, Investigators M. Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial. Lancet 2015;385:2465-2476.
6. Gutierrez A, Tsai TT, Stanislawski MA, Vidovich M, Bryson CL, Bhatt DL, Grunwald GK, Rumsfeld J, Rao SV. Adoption of transradial percutaneous coronary intervention and outcomes according to center radial volume in the Veterans Affairs Healthcare system: insights from the Veterans Affairs clinical assessment, reporting, and tracking (CART) program. Circ Cardiovasc Interv 2013;6: 336-346.
7. Hamon M, Pristipino C, Di Mario C, Nolan J, Ludwig J, Tubaro M, Sabate M, Mauri-Ferre J, Huber K, Niemela K, Haude M, Wijns W, Dudek D, Fajadet J, Kiemeneij F, European Association of Percutaneous Cardiovascular I, Working Group on Acute Cardiac Care of the European Society of C, Working Group on Thrombosis on the European Society of C. Consensus document on the radial approach in percutaneous cardiovascular interventions: position paper by the European Association of Percutaneous Cardiovascular Interventions andWorking Groups on Acute Cardiac Care and Thrombosis of the European Society of Cardiology. EuroIntervention 2013;8:1242-1251.
8. Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Nallamothu BK, Ting HH, Accf, Aha, Scai. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Catheter Cardiovasc Interv 2012;79: 453-495.
9. Bhatt DL, Stone GW, Mahaffey KW, Gibson CM, Steg PG, Hamm CW, Price MJ, Leonardi S, Gallup D, Bramucci E, Radke PW, Widimsky P, Tousek F, Tauth J, Spriggs D, McLaurin BT, Angiolillo DJ, Genereux P, Liu T, Prats J, Todd M, Skerjanec S, White HD, Harrington RA, Investigators CP. Effect of platelet inhibition with cangrelor during PCI on ischemic events. N Engl J Med 2013;368: 1303-1313.
10. Leonardi S, Mahaffey KW, White HD, Gibson CM, Stone GW, Steg GW, Hamm CW, Price MJ, Todd M, Dietrich M, Gallup D, Liu T, Skerjanec S, Harrington RA, Bhatt DL. Rationale and design of the cangrelor versus standard therapy to acHieve optimal Management of Platelet InhibitiON PHOENIX trial. Am Heart J 2012;163:768-776 e2.
11. Genereux P, Stone GW, Harrington RA, Gibson CM, Steg PG, Brener SJ, Angiolillo DJ, Price MJ, Prats J, Lasalle L, Liu T, Todd M, Skerjanec S, Hamm CW, Mahaffey KW, White HD, Bhatt DL, Investigators CP. Impact of intraprocedural stent thrombosis during percutaneous coronary intervention: insights from the CHAMPION PHOENIX Trial (Clinical Trial Comparing Cangrelor to Clopidogrel Standard of Care Therapy in Subjects Who Require Percutaneous Coronary Intervention). J Am Coll Cardiol 2014;63:619-629.
12. Rao SV, Cohen MG, Kandzari DE, Bertrand OF, Gilchrist IC. The transradial approach to percutaneous coronary intervention: historical perspective, current concepts, and future directions. J Am Coll Cardiol 2010;55:2187-2195.
13. Rao SV, Turi ZG, Wong SC, Brener SJ, Stone GW. Radial versus femoral access. J Am Coll Cardiol 2013;62(17 Suppl):S11-S20.