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Volumn 31, Issue 3, 2016, Pages 329-331

The use of dose-response data in a margin of exposure approach to carcinogenic risk assessment for genotoxic chemicals in food

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL COMPOUND; CARCINOGEN; MUTAGENIC AGENT;

EID: 84966508425     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gev064     Document Type: Review
Times cited : (29)

References (10)
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    • Barlow, S., Renwick, A. G., Kleiner, J., et al. (2006) Risk assessment of substances that are both genotoxic and carcinogenic-Report of an international conference organised by EFSA and WHO with support of ILSI Europe. Food Chem. Toxicol., 44, 1636-1650.
    • (2006) Food Chem. Toxicol , vol.44 , pp. 1636-1650
    • Barlow, S.1    Renwick, A.G.2    Kleiner, J.3
  • 3
    • 74549215283 scopus 로고    scopus 로고
    • Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic
    • Benford D., Bolger P. M., Carthew P., et al. (2010) Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Food Chem. Toxicol., 48, S2-24.
    • (2010) Food Chem. Toxicol , vol.48 , pp. S2-24
    • Benford, D.1    Bolger, P.M.2    Carthew, P.3
  • 4
    • 84966686365 scopus 로고    scopus 로고
    • COC (Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment) Risk characterisation methods Ref: COC/G 06-Version 1.0. (accessed August 17 2015)
    • COC (Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment). (2012) Risk characterisation methods Ref: COC/G 06-Version 1.0. https://www.gov.uk/government/publications/cancer-risk-characterisation-methods (accessed August 17, 2015).
    • (2012)
  • 5
    • 84928789893 scopus 로고    scopus 로고
    • IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PODs)
    • [Epub October 13 2014]
    • MacGregor J. T., Frötschl R., White P. A., et al. (2015) IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PODs). Mutat. Res.: Genet. Toxicol. Environ. Mutagen., 783, 55-65 [Epub October 13, 2014], doi:10.1016/j.mrgentox.2014.09.011.
    • (2015) Mutat. Res.: Genet. Toxicol. Environ. Mutagen , vol.783 , pp. 55-65
    • MacGregor, J.T.1    Frötschl, R.2    White, P.A.3
  • 6
    • 84903521466 scopus 로고    scopus 로고
    • Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: Considerations of biological releVance of tumour type, data quality and uncertainty assessment
    • Edler L., Hart A., Greaves P., Carthew P., Coulet M., Boobis A., Williams G. M., Smith B. (2014) Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: considerations of biological releVance of tumour type, data quality and uncertainty assessment. Food Chem. Toxicol., 70, 264-289.
    • (2014) Food Chem. Toxicol , vol.70 , pp. 264-289
    • Edler, L.1    Hart, A.2    Greaves, P.3    Carthew, P.4    Coulet, M.5    Boobis, A.6    Williams, G.M.7    Smith, B.8
  • 7
    • 77149171287 scopus 로고    scopus 로고
    • Guidance of the Scientific Committee on a request from EFSA on the use of the benchmark dose approach in risk assessment
    • EFSA (European Food Safety Authority)
    • EFSA (European Food Safety Authority). (2009) Guidance of the Scientific Committee on a request from EFSA on the use of the benchmark dose approach in risk assessment. EFSA Journal, 1150, 1-72.
    • (2009) EFSA Journal , vol.1150 , pp. 1-72
  • 8
    • 84907490974 scopus 로고    scopus 로고
    • Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment
    • Johnson G. E., Soeteman-Hernández L. G., Gollapudi B. B., et al. (2014) Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ. Mol. Mutagen., 55, 609-623.
    • (2014) Environ. Mol. Mutagen , vol.55 , pp. 609-623
    • Johnson, G.E.1    Soeteman-Hernández, L.G.2    Gollapudi, B.B.3
  • 10
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    • IWGT report on quantitative approaches to genotoxicity risk assessment II Use of point-ofdeparture (PoD) metrics in defining acceptable exposure limits and assessing human risk
    • [Epub October 13 2014]
    • MacGregor J. T., Frötschl R., White P. A., et al. (2015) IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-ofdeparture (PoD) metrics in defining acceptable exposure limits and assessing human risk. Mutat. Res.: Genet. Toxicol. Environ. Mutagen., 783, 55-65 [Epub October 13, 2014], doi:10.1016/j.mrgentox.2014.09.011.
    • (2015) Mutat. Res.: Genet. Toxicol. Environ. Mutagen , vol.783 , pp. 55-65
    • MacGregor, J.T.1    Frötschl, R.2    White, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.