Characteristics, Diagnosis and Prognosis of Acute-on-Chronic Liver Failure in Cirrhosis Associated to Hepatitis B

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Li, Hai ^a,b,c   Chen, Liu Ying ^a,b,c   Zhang, Nan Nan ^a,b,c   Li, Shu Ting ^a,b,c   Zeng, Bo ^a,b,c   Pavesi, Marco ^d   Amorós, Àlex ^d   Mookerjee, Rajeshwar P ^h   Xia, Qian ^a   Xue, Feng ^a   Ma, Xiong ^a,b,c   Hua, Jing ^a,b,c   Sheng, Li ^a,b,c   Qiu, De Kai ^a,b,c   Xie, Qing ^a   Foster, Graham R ^e   Dusheiko, Geoffrey ^h   Moreau, Richard ^f   Gines, Pere ^g   Arroyo, Vicente ^d,g   Jalan, Rajiv ^h   more..

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Institute of Digestive Disease   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d European Foundation for the Study of Chronic Liver Failure (EF CLIF)   (Spain)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f BEAUJON HOSPITAL   (France)

^g HOSPITAL CLÍNIC   (Spain)

^h UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; VIRUS DNA;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; CHRONIC HEPATITIS B; COMPLICATION; DIFFERENTIAL DIAGNOSIS; FEMALE; GENETICS; HEPATITIS B VIRUS; HUMAN; LEUKOCYTE COUNT; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; MORTALITY; PATHOGENICITY; PATHOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS; VIROLOGY;

ACUTE-ON-CHRONIC LIVER FAILURE; ADULT; BIOMARKERS; DIAGNOSIS, DIFFERENTIAL; DNA, VIRAL; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LEUKOCYTE COUNT; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS;

EID: 84966425147     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep25487     Document Type: Article

References (35)

1. Jalan, R. et al. Acute-on chronic liver failure. J Hepatol 57, 1336-1348, doi: 10.1016/j.jhep.2012.06.026 (2012).
2. Olson, J. C. et al. Intensive care of the patient with cirrhosis. Hepatology 54, 1864-1872, doi: 10.1002/hep.24622 (2011).
3. Jalan, R. et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol 61, 1038-1047, doi: 10.1016/j.jhep.2014.06.012 (2014).
4. Moreau, R. et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology 144, 1426-1437, 1437.e1421-1429, doi: 10.1053/j.gastro.2013.02.042 (2013).
5. Jalan, R. et al. The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure. J Hepatol 62, 831-840, doi: 10.1016/j.jhep.2014.11.012 (2015).
6. Bajaj, J. S. et al. Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures. Hepatology 60, 250-256, doi: 10.1002/hep.27077 (2014).
7. Sarin, S. K. et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int 3, 269-282, doi: 10.1007/s12072-008-9106-x (2009).
8. Bajaj, J. S. Defining acute-on-chronic liver failure: will East and West ever meet? Gastroenterology 144, 1337-1339, doi: 10.1053/j.gastro.2013.04.024 (2013).
9. Jalan, R. et al. Toward an improved definition of acute-on-chronic liver failure. Gastroenterology 147, 4-10, doi: 10.1053/j.gastro.2014.05.005 (2014).
10. Li, H. et al. Submassive hepatic necrosis distinguishes HBV-associated acute-on chronic liver failure from cirrhotic patients with acute decompensation. J Hepatol, doi: 10.1016/j.jhep.2015.01.029 (2015).
11. Mookerjee, R. P. et al. The role of liver biopsy in the diagnosis and prognosis of patients with acute deterioration of alcoholic cirrhosis. J Hepatol 55, 1103-1111, doi: 10.1016/j.jhep.2011.02.021 (2011).
12. Katoonizadeh, A. et al. Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study. Gut 59, 1561-1569, doi: 10.1136/gut.2009.189639 (2010).
13. Singal, A. K. & Fontana, R. J. Meta-analysis: oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis. Aliment Pharmacol Ther 35, 674-689, doi: 10.1111/j.1365-2036.2011.04990.x (2012).
14. Wai, C. T. et al. Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States. J Viral Hepat 12, 192-198, doi: 10.1111/j.1365-2893.2005.00581.x (2005).
15. Dao, D. Y. et al. Use of nucleoside (tide) analogues in patients with hepatitis B-related acute liver failure. Dig Dis Sci 57, 1349-1357, doi: 10.1007/s10620-011-2013-3 (2012).
16. Perrillo, R. P. Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease. Gastroenterology 120, 1009-1022 (2001).
17. Dao, D. Y. et al. Two distinct subtypes of hepatitis B virus-related acute liver failure are separable by quantitative serum immunoglobulin M anti-hepatitis B core antibody and hepatitis B virus DNA levels. Hepatology 55, 676-684, doi: 10.1002/hep.24732 (2012).
18. Trawale, J. M. et al. The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study. Liver Int 30, 725-732, doi: 10.1111/j.1478-3231.2009.02182.x (2010).
19. Shah, N. et al. Increased renal expression and urinary excretion of TLR4 in acute kidney injury associated with cirrhosis. Liver Int 33, 398-409, doi: 10.1111/liv.12047 (2013).
20. Jalan, R. et al. Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol 60, 1310-1324, doi: 10.1016/j.jhep.2014.01.024 (2014).
21. Kim, W. R. et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 359, 1018-1026, doi: 10.1056/NEJMoa0801209 (2008).
22. Medzhitov, R., Schneider, D. S. & Soares, M. P. Disease tolerance as a defense strategy. Science 335, 936-941, doi: 10.1126/science.1214935 (2012).
23. Kamath, P. S. & Kim, W. R. The model for end-stage liver disease (MELD). Hepatology 45, 797-805, doi: 10.1002/hep.21563 (2007).
24. Shi, Y. et al. Acute-on-chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults. Hepatology 62, 232-242, doi: 10.1002/hep.27795 (2015).
25. Theocharidou, E. et al. The Royal Free Hospital score: a calibrated prognostic model for patients with cirrhosis admitted to intensive care unit. Comparison with current models and CLIF-SOFA score. Am J Gastroenterol 109, 554-562, doi: 10.1038/ajg.2013.466 (2014).
26. Silva, P. E. et al. Single-centre validation of the EASL-CLIF Consortium definition of acute-on-chronic liver failure and CLIF-SOFA for prediction of mortality in cirrhosis. Liver Int, doi: 10.1111/liv.12597 (2014).
27. Pan, H. C. et al. Scoring systems for 6-month mortality in critically ill cirrhotic patients: a prospective analysis of chronic liver failure - sequential organ failure assessment score (CLIF-SOFA). Aliment Pharmacol Ther 40, 1056-1065, doi: 10.1111/apt.12953 (2014).
28. McPhail, M. J. et al. Increased Survival for Patients With Cirrhosis and Organ Failure in Liver Intensive Care and Validation of the Chronic Liver Failure-Sequential Organ Failure Scoring System. Clin Gastroenterol Hepatol, doi: 10.1016/j.cgh.2014.08.041 (2014).
29. Lee, M. et al. CLIF-SOFA scoring system accurately predicts short-term mortality in acutely decompensated patients with alcoholic cirrhosis: a retrospective analysis. Liver Int 35, 46-57, doi: 10.1111/liv.12683 (2015).
30. Dhiman, R. K., Agrawal, S., Gupta, T., Duseja, A. & Chawla, Y. Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome. World J Gastroenterol 20, 14934-14941, doi: 10.3748/wjg.v20.i40.14934 (2014).
31. Agrawal, S., Duseja, A., Gupta, T., Dhiman, R. K. & Chawla, Y. Simple organ failure count versus CANONIC grading system for predicting mortality in acute-on-chronic liver failure. J Gastroenterol Hepatol 30, 575-581, doi: 10.1111/jgh.12778 (2015).
32. Lok, A. S. & McMahon, B. J. Chronic hepatitis B. Hepatology 45, 507-539, doi: 10.1002/hep.21513 (2007).
33. Hui, C. K. et al. Kinetics and risk of de novo hepatitis B infection in HBsAg-negative patients undergoing cytotoxic chemotherapy. Gastroenterology 131, 59-68, doi: 10.1053/j.gastro.2006.04.015 (2006).
34. Hoofnagle, J. H. Reactivation of hepatitis B. Hepatology 49, S156-165, doi: 10.1002/hep.22945 (2009).
35. Harrell, F. E., Jr., Lee, K. L. & Mark, D. B. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 15, 361-387, doi: 10.1002/(sici)1097-0258(19960229)15:4<361::aidsim168>3.0.co;2-4 (1996).