Treating giant-cell arteritis: Is IL-6 the cytokine to target?

The Lancet

Volumn 387, Issue 10031, 2016, Pages 1882-1883

  Guillevin, Loïc ^a,b   Régent, Alexis ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Institut Cochin   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; INTERLEUKIN 6; METHOTREXATE; PLACEBO; TOCILIZUMAB; ANTIINFLAMMATORY AGENT; MONOCLONAL ANTIBODY;

BIOLOGICAL THERAPY; CD4+ T LYMPHOCYTE; DENDRITIC CELL; DISEASE ACTIVITY; DRUG EFFICACY; DRUG TARGETING; GASTROINTESTINAL SYMPTOM; GIANT CELL ARTERITIS; HUMAN; NOTE; PRIORITY JOURNAL; RELAPSE; T LYMPHOCYTE; TH1 CELL; FEMALE; MALE;

ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL, HUMANIZED; FEMALE; GIANT CELL ARTERITIS; HUMANS; MALE;

EID: 84966340422     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)30183-0     Document Type: Note

References (11)

1. CM Weyand, JJ Goronzy Giant-cell arteritis and polymyalgia rheumatica N Engl J Med 371 2014 1653
2. K-H Ly, A Régent, MC Tamby, L Mouthon Pathogenesis of giant cell arteritis: More than just an inflammatory condition? Autoimmun Rev 9 2010 635 645
3. B Terrier, G Geri, W Chaara et al. Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis Arthritis Rheum 64 2012 2001 2011
4. M Samson, S Audia, J Fraszczak et al. Th1 and Th17 lymphocytes expressing CD161 are implicated in giant cell arteritis and polymyalgia rheumatica pathogenesis Arthritis Rheum 64 2012 3788 3798
5. M Samson, S Audia, L Martin, N Janikashvili, B Bonnotte Pathogenesis of giant cell arteritis: new insight into the implication of CD161+ T cells Clin Exp Rheumatol 31 2013 S65 S73
6. M Samson, B Bonnotte Treg cells in giant cell arteritis: might they be another target for adjuvant treatment? Comment on the article by Samson et al. Reply Arthritis Rheum 65 2013 289 290
7. A Proven, SE Gabriel, C Orces, WM O'Fallon, GG Hunder Glucocorticoid therapy in giant cell arteritis: duration and adverse outcomes Arthritis Rheum 49 2003 703 708
8. AD Mahr, JA Jover, RF Spiera et al. Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis Arthritis Rheum 56 2007 2789 2797
9. NE Roche, JW Fulbright, AD Wagner, GG Hunder, JJ Goronzy, CM Weyand Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis Arthritis Rheum 36 1993 1286 1294
10. M Rincon Interleukin-6: from an inflammatory marker to a target for inflammatory diseases Trends Immunol 33 2012 571 577
11. PM Villiger, S Adler, S Kuchen et al. Tocilizumab for induction and maintenance of remission in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial Lancet 387 2016 1921 1927