A Multidimensional Risk Score to Predict All-Cause Hospitalization in Community-Dwelling Older Individuals With Obstructive Lung Disease

Journal of the American Medical Directors Association

Volumn 17, Issue 6, 2016, Pages 508-513

  Beijers, Rosanne J H C G ^a   van den Borst, Bram ^a   Newman, Anne B ^b   Yende, Sachin ^c,d   Kritchevsky, Stephen B ^e   Cassano, Patricia A ^f,g   Bauer, Douglas C ^h   Harris, Tamara B ⁱ   Schols, Annemie M W J ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e WAKE FOREST SCHOOL OF MEDICINE   (United States)

^f Weill Cornell Medical College ^*  (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ Gateway Building 3C309   (United States)

Author keywords

COPD; Cox proportional hazards modeling; Older age persons; Pulmonary disease

Indexed keywords

AGED; ALL CAUSE HOSPITALIZATION; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMMUNITY LIVING; CONFIDENCE INTERVAL; FEMALE; FOLLOW UP; HAZARD RATIO; HEART DISEASE; HOSPITALIZATION; HOSPITALL SCORE; HUMAN; INFLAMMATION; LEG DISEASE; MAJOR CLINICAL STUDY; MALE; PREDICTION; RISK ASSESSMENT; SCORING SYSTEM; VASCULAR DISEASE; HOME FOR THE AGED; PROCEDURES; PROPORTIONAL HAZARDS MODEL;

AGED; FEMALE; HOMES FOR THE AGED; HOSPITALIZATION; HUMANS; LUNG DISEASES, OBSTRUCTIVE; MALE; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT;

EID: 84966340227     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2016.01.007     Document Type: Article

References (40)

1. Pitta F., Troosters T., Spruit M.A., et al. Characteristics of physical activities in daily life in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005, 171:972-977.
2. Watz H., Waschki B., Boehme C., et al. Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: A cross-sectional study. Am J Respir Crit Care Med 2008, 177:743-751.
3. Jansson S.A., Backman H., Ronmark E., et al. Hospitalization due to co-morbid conditions is the main cost driver among subjects with COPD. A report from the population-based OLIN COPD Study. COPD 2015, 12:381-389.
4. Ford E.S. Hospital discharges, readmissions, and ED visits for COPD or bronchiectasis among US adults: Findings from the nationwide inpatient sample 2001-2012 and Nationwide Emergency Department Sample 2006-2011. Chest 2015, 147:989-998.
5. Mullerova H., Maselli D.J., Locantore N., et al. Hospitalized exacerbations of COPD: Risk factors and outcomes in the ECLIPSE cohort. Chest 2015, 147:999-1007.
6. Aaron S.D., Vandemheen K.L., Fergusson D., et al. Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: A randomized trial. Ann Intern Med 2007, 146:545-555.
7. Fan V.S., Gaziano J.M., Lew R., et al. A comprehensive care management program to prevent chronic obstructive pulmonary disease hospitalizations: A randomized, controlled trial. Ann Intern Med 2012, 156:673-683.
8. Niewoehner D.E., Rice K., Cote C., et al. Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: A randomized trial. Ann Intern Med 2005, 143:317-326.
9. Lainscak M., Kadivec S., Kosnik M., et al. Discharge coordinator intervention prevents hospitalizations in patients with COPD: A randomized controlled trial. J Am Med Dir Assoc 2013, 14:450.e1-450.e6.
10. Ramon M.A., Gimeno-Santos E., Ferrer J., et al. Hospital admissions and exercise capacity decline in patients with COPD. Eur Respir J 2014, 43:1018-1027.
11. Dalal A.A., Christensen L., Liu F., et al. Direct costs of chronic obstructive pulmonary disease among managed care patients. Int J Chron Obstruct Pulmon Dis 2010, 5:341-349.
12. Shah T., Churpek M.M., Coca Perraillon M., et al. Understanding why patients with COPD get readmitted: A large national study to delineate the Medicare population for the readmissions penalty expansion. Chest 2015, 147:1219-1226.
13. Ponzetto M., Zanocchi M., Maero B., et al. Post-hospitalization mortality in the elderly. Arch Gerontol Geriatr 2003, 36:83-91.
14. Wong R.Y., Miller W.C. Adverse outcomes following hospitalization in acutely ill older patients. BMC Geriatr 2008, 8:10.
15. Holguin F., Folch E., Redd S.C., et al. Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001. Chest 2005, 128:2005-2011.
16. Moberg M., Vestbo J., Martinez G., et al. Validation of the i-BODE index as a predictor of hospitalization and mortality in patients with COPD participating in pulmonary rehabilitation. COPD 2014, 11:381-387.
17. Zanoria S.J., ZuWallack R. Directly measured physical activity as a predictor of hospitalizations in patients with chronic obstructive pulmonary disease. Chron Respir Dis 2013, 10:207-213.
18. van den Borst B., Koster A., Yu B., et al. Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?. Thorax 2011, 66:961-969.
19. Yende S., Waterer G.W., Tolley E.A., et al. Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax 2006, 61:10-16.
20. Mehrotra N., Freire A.X., Bauer D.C., et al. Predictors of mortality in elderly subjects with obstructive airway disease: The PILE score. Ann Epidemiol 2010, 20:223-232.
21. Inker L.A., Schmid C.H., Tighiouart H., et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 2012, 367:20-29.
22. Teng E.L., Chui H.C. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 1987, 48:314-318.
23. BMI classification 2006, World Health Organization, Available at:, Accessed September 24, 2015. http://apps.who.int/bmi/index.jsp?introPage=intro_3.html.
24. Vestbo J., Hurd S.S., Agusti A.G., et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013, 187:347-365.
25. Lange-Maia B.S., Strotmeyer E.S., Harris T.B., et al. Physical activity and change in long distance corridor walk performance in the Health, Aging, and Body Composition Study. J Am Geriatr Soc 2015, 63:1348-1354.
26. Sullivan L.M., Massaro J.M., D'Agostino R.B. Presentation of multivariate data for clinical use: The Framingham Study risk score functions. Stat Med 2004, 23:1631-1660.
27. Hankinson J.L., Odencrantz J.R., Fedan K.B. Spirometric reference values from a sample of the general US population. Am J Respir Crit Care Med 1999, 159:179-187.
28. Mahler D.A., Wells C.K. Evaluation of clinical methods for rating dyspnea. Chest 1988, 93:580-586.
29. Mannino D.M., Higuchi K., Yu T.C., et al. Economic burden of COPD in the presence of comorbidities. Chest 2015, 148:138-150.
30. Mullerova H., Agusti A., Erqou S., et al. Cardiovascular comorbidity in COPD: Systematic literature review. Chest 2013, 144:1163-1178.
31. Chen W., Thomas J., Sadatsafavi M., et al. Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis. Lancet Respir Med 2015, 3:631-639.
32. van den Borst B., Gosker H.R., Schols A.M. Central fat and peripheral muscle: Partners in crime in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013, 187:8-13.
33. Patel M.S., Mohan D., Andersson Y.M., et al. Phenotypic characteristics associated with reduced short physical performance battery score in COPD. Chest 2014, 145:1016-1024.
34. Guralnik J.M., Ferrucci L., Simonsick E.M., et al. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 1995, 332:556-561.
35. Volpato S., Cavalieri M., Sioulis F., et al. Predictive value of the Short Physical Performance Battery following hospitalization in older patients. J Gerontol A Biol Sci Med Sci 2011, 66:89-96.
36. Barnes P.J., Celli B.R. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009, 33:1165-1185.
37. Agusti A., Edwards L.D., Rennard S.I., et al. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: A novel phenotype. PLoS One 2012, 7:e37483.
38. Rutten E.P., Breyer M.K., Spruit M.A., et al. Abdominal fat mass contributes to the systemic inflammation in chronic obstructive pulmonary disease. Clin Nutr 2010, 29:756-760.
39. Broekhuizen R., Wouters E.F., Creutzberg E.C., et al. Raised CRP levels mark metabolic and functional impairment in advanced COPD. Thorax 2006, 61:17-22.
40. Dahl M., Vestbo J., Lange P., et al. C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007, 175:250-255.