Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions

Cochrane Database of Systematic Reviews

Volumn 2015, Issue 12, 2015, Pages

  van Galen, Karin P M ^a   Engelen, Eveline T ^b   Mauser Bunschoten, Evelien P ^a   van Es, Robert J J ^b   Schutgens, Roger E G ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT; HEMOGLOBIN; TRANEXAMIC ACID; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9;

BLEEDING; CLINICAL OUTCOME; DISEASE DURATION; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; DRUG WITHDRAWAL; ERYTHROCYTE TRANSFUSION; HEADACHE; HEMOPHILIA; HUMAN; NAUSEA; OPERATIVE BLOOD LOSS; ORAL BLEEDING; ORAL SURGERY; POSITIONAL DIZZINESS; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK; RISK REDUCTION; SKIN TINGLING; SYSTEMATIC REVIEW; TOOTH EXTRACTION; UNSPECIFIED SIDE EFFECT; VON WILLEBRAND DISEASE; WOUND INFECTION; ADVERSE EFFECTS; BLOOD LOSS, SURGICAL; COMPLICATION; HEMOPHILIA A; HEMOPHILIA B; META ANALYSIS; MINOR SURGERY; ORAL HEMORRHAGE; VON WILLEBRAND DISEASES;

AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; FACTOR IX; FACTOR VIII; HEMOPHILIA A; HEMOPHILIA B; HUMANS; MINOR SURGICAL PROCEDURES; ORAL HEMORRHAGE; POSTOPERATIVE HEMORRHAGE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SURGERY, ORAL; TOOTH EXTRACTION; TRANEXAMIC ACID; VON WILLEBRAND DISEASES;

EID: 84965191811     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD011385.pub2     Document Type: Review

References (60)

1. Forbes CD, Barr RD, Reid G, Thomson C, Prentice CR, McNicol GP, et al. Tranexamic acid in control of haemorrhage after dental extraction in haemophilia and Christmas disease. British Medical Journal 1972;2(5809):311-3. [CENTRAL: 7017; CRS: 5500100000000018; PUBMED: 4553818]
2. Walsh PN, Rizza CR, Matthews JM, Eipe J, Kernoff PB, Coles MD, et al. Epsilon-Aminocaproic acid therapy for dental extractions in haemophilia and Christmas disease: a double blind controlled trial. British Journal of Haematology 1971;20(5):463-75. [CENTRAL: 5784; CRS: 5500100000000016; PUBMED: 4931484]
3. Beck EA. Re: tranexamic acid and bleeding: a double-blind cross-over study on three brothers with Christmas disease (Factor IX deficiency). Thrombosis and Haemostasis 1976;35(2):492-4. [CENTRAL: 14741; CRS: 5500100000000052; PUBMED: 788220]
4. Bennett AE, Ingram GI, Inglish PJ. Antifibrinolytic treatment in haemophilia: a controlled trial of prophylaxis with tranexamic acid. British Journal of Haematology 1973;24(1):83-8. [CENTRAL: 8724; CRS: 5500100000000024; PUBMED: 4577064]
5. Biggs R, Hayton-Williams DS. Epsilon-aminocaproic acid in the treatment of hemophilia. British Dental Journal 1968;124(4):157. [PUBMED: 5299942]
6. Bump RL, Kolodny SC. Fibrinolysis: a possible factor in the control of postoperative hemorrhage in the patient with hemophilia. Oral Surgery, Oral Medicine, and Oral Pathology 1973;36(2):195-200. [PUBMED: 4541641]
7. Casdorph DL. Topical aminocaproic acid in hemophiliac patients undergoing dental extraction. DICP: The Annals of Pharmacotherapy 1990;24(2):160-1. [PUBMED: 2309511]
8. Coetzee MJ. The use of topical crushed tranexamic acid tablets to control bleeding after dental surgery and from skin ulcers in haemophilia. Haemophilia: The Official Journal of the World Federation of Hemophilia 2007; Vol. 13, issue 4:443-4. [PUBMED: 17610565]
9. Cooksey MW, Perry CB, Raper AB. Epsilon-aminocaproic acid therapy for dental extractions in haemophiliacs. British Medical Journal 1966;2(5530):1633-4. [PUBMED: 5297046]
10. Corrigan JJ Jr. Oral bleeding in hemophilia: treatment with epsilon aminocaproic acid and replacement therapy. Journal of Pediatrics 1972;80(1):124-8. [PUBMED: 4536942]
11. Evans BE. The use of epsilon-aminocaproic acid for the management of hemophilia in dental and oral surgery patients. Journal of the American Dental Association (1939) 1977; Vol. 94, issue 1:21. [PUBMED: 264310]
12. Evans BE. The use of epsilon aminocaproic acid as an adjunct to replacement therapy in hemophiliacs undergoing tooth extraction. (Part I). The New York Journal of Dentistry 1981;51(3):83-90. [PUBMED: 7010243]
13. Evans BE. The use of epsilon aminocaproic acid as an adjunct to replacement therapy in hemophiliacs undergoing tooth extraction (part II). The New York Journal of Dentistry 1981;51(4):117-27. [PUBMED: 6784050]
14. Gordon AM, McNicol GP, Dubber AH, McDonald GA, Douglas AS. Clinical trial of epsilon-aminocaproic acid in severe haemophilia. British Medical Journal 1965;1:1632-5. [CENTRAL: 208612; CRS: 5500100000001126]
15. Ingram GI, Inglish PJ, Bennett AE. Tranexamic acid for prophylaxis in haemophilia. [abstract]. Journal of Clinical Pathology 1972;25(7):629. [CENTRAL: 7639; CRS: 5500100000000019; PUBMED: 4560842]
16. Kontras SB, Steiner D, Kramer N. Use of epsilon-aminocaproic acid in hemophiliacs for dental extractions. The Ohio State Medical Journal 1969;65(4):391-3. [PUBMED: 5798682]
17. Lee AP, Boyle CA, Savidge GF, Fiske J. Effectiveness in controlling haemorrhage after dental scaling in people with haemophilia by using tranexamic acid mouthwash. British Dental Journal 2005;198(1):33-8. [CENTRAL: 502642; CRS: 5500100000002667; PUBMED: 15716891]
18. Lurie A, Silverman NH, Jackson FR. An approach to dental extractions in haemophilia and related bleeding disorders in children. South African Medical Journal (Suid-Afrikaanse Tydskrif vir Geneeskunde) 1972;46(45):1743-6. [PUBMED: 4541519]
19. Paddon AJ. The use of epsilon aminocaproic acid as supplementary treatment of the haemophiliac undergoing surgery. The Journal of the Dental Association of South Africa (Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika) 1967;22(3):64-9. [PUBMED: 5297733]
20. Pizzoni D, Cortellaro M, Mannucci PM. Replacement therapy and local measures for dental extractions in haemophiliacs: comparison of various schemes of treatment. Rassegna Internazionale di Stomatologia Pratica 1971;22(4):153-7. [PUBMED: 5316217]
21. Reid WO, Lucas ON, Francisco J, Geisler PH, Erslev AJ. The use of epsilon-aminocaproic acid in the management of dental extractions in the hemophiliac. American Journal of the Medical Sciences 1964;248:184-8. [PUBMED: 14206770]
22. Schiavoni M, Ettore C, Antoncecchi S, Ciavarella N, Schannong M. Tranexamic acid as prophylaxis in haemophilia. A randomized double-blind study [abstract]. Thrombosis and Haemostasis 1983;50:444. [CENTRAL: 208605; CRS: 5500100000001123]
23. Short SG, Ogle RG. Extractions in hemophilia. Use of EACA. Minnesota Medicine 1974;57(2):77-80. [PUBMED: 4544337]
24. Stajcic Z. The combined local/systemic use of antifibrinolytics in hemophiliacs undergoing dental extractions. International Journal of Oral Surgery 1985;14(4):339-45. [CENTRAL: 318231; CRS: 5500100000001764]
25. Stajcic Z, Baklaja R, Elezovic I, Rolovic Z. Primary wound closure in haemophiliacs undergoing dental extractions. International Journal of Oral and Maxillofacial Surgery 1989;18(1):14-6. [CENTRAL: 318232; CRS: 5500100000001765]
26. Tavenner RW. Use of tranexamic acid in control of haemorrhage after extraction of teeth in haemophilia and Christmas disease. British Medical Journal 1972;2(5809):314-5. [PUBMED: 4537105]
27. Verbeck C. On the oral surgery in hemophilic patients [Uber zahnarztlich-chirurgische Eingriffe bei Hamophilie-Kranken]. Deutsche zahnarztliche Zeitschrift 1967;21(12):594-6. [PUBMED: 5299777]
28. Verstraete M, Ruys CAJ. Double-blind experiments on the effect of a peanut extract on the bleeding incidence in 92 haemophiliacs. British Medical Journal 1967;4(5577):453-6. [CENTRAL: 1481; CRS: 5500100000000004; PUBMED: 4861744]
29. Wolman IJ. Peanuts and hemophilia. Clinical Pediatrics 1968;7(6):311. [CENTRAL: 1925; CRS: 5500100000000005; PUBMED: 4869852]
30. Waly NG. Local antifibrinolytic treatment with tranexamic acid in hemophilic children undergoing dental extractions. Egyptian Dental Journal 1995;41(1):961-8. [CENTRAL: 148388; CRS: 5500100000000863; PUBMED: 9497628]
31. Williamson R, Eggleston DJ. DDAVP and EACA used for minor oral surgery in von Willebrand disease. Australian Dental Journal 1988;33(1):32-6. [PUBMED: 2970252]
32. Broze GJ Jr, Higuchi DA. Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma. Blood 1996;88(10):3815-23.
33. Coppola A, Windyga J, Tufano A, Yeung C, Di Minno MN. Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgery. Cochrane Database of Systematic Reviews 2015, Issue 2. [DOI: 10.1002/14651858.CD009961.pub2; PUBMED: 25922858]
34. Deeks JJ, Higgins JPT, Altman DG on behalf of the Cochrane Statistical Methods Group. Chapter 9 Analysing data and undertaking meta-analysis. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
35. Federici AB, Sacco R, Stabile F, Carpenedo M, Zingaro E, Mannucci PM. Optimising local therapy during oral surgery in patients with von Willebrand disease: effective results from a retrospective analysis of 63 cases. Haemophilia: the official journal of the World Federation of Hemophilia 2000;6(2):71-7. [PUBMED: 10781191]
36. Gandhi R, Evans HM, Mahomed SR, Mahomed NN. Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis. BMC Research Notes 2013;6:184.
37. Hermans C, Altisent C, Batorova A, Chambost H, De Moerloose P, Karafoulidou A, et al. Replacement therapy for invasive procedures in patients with haemophilia: literature review, European survey and recommendations. Haemophilia: the official journal of the World Federation of Hemophilia 2009;15(3):639-58. [PUBMED: 19444969]
38. Hewson I, Makhmalbaf P, Street A, McCarthy P, Walsh M. Dental surgery with minimal factor support in the inherited bleeding disorder population at the Alfred Hospital. Haemophilia: the official journal of the World Federation of Hemophilia 2011;17(1):e185-8. [PUBMED: 20557354]
39. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60.
40. Higgins JPT, Deeks JJ (editors). Chapter 7: Selecting studies and collecting data. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
41. Higgins JPT, Altman DG, Sterne JAC on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
42. Higgins JPT, Deeks JJ, Altman DG on behalf of the Cochrane Statistical Methods Group (editors). Chapter 16: Special topics in statistics. In: Higgins JPT, Green S (editors). Cochrane Handbook of Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
43. Katsaros D, Petricevic M, Snow NJ, Woodhall DD, Van Bergen R. Tranexamic acid reduces postbypass blood use: a double-blinded, prospective, randomised study of 210 patients. Annals of Thoracic Surgery 1996;61(4):1131-5.
44. Kaufman RJ, Powell JS. Molecular approaches for improved clotting factors for hemophilia. Blood 2013;122:3568-74.
45. Later AF, Maas JJ, Engbers FH, Versteegh MI, Bruggemans EF, Dion RA, et al. Tranexamic acid and aprotinin in low-and intermediate-risk cardiac surgery: a non-sponsored, double-blind, randomised, placebo-controlled trial. European Journal of Cardio-thoracic Surgery 2009;36(2):322-9.
46. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009;339:b2700. [DOI: 10.1136/bmj.b2700]
47. Maddali MM, Rajakumar MC. Tranexamic acid and primary coronary artery bypass surgery: a prospective study. Asian Cardiovascular & Thorac Annals 2007;15(4):313-9.
48. Madrid C, Sanz M. What influence do anticoagulants have on oral implant therapy? A systematic review. Clinical Oral Implants Research 2009;20 Suppl 4:96-106.
49. McCormack PL. Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 2012;72(5):585-617.
50. Pell G. Tranexamic acid -its use in controlling dental post-operative bleeding in patients with defective clotting mechanisms. The British Journal of Oral Surgery 1973;11(2):155-64.
51. Perel P, Ker K, Morales Uribe CH, Roberts I. Tranexamic acid for reducing mortality in emergency and urgent surgery. Cochrane Database of Systematic Reviews 2013, Issue 1. [DOI: 10.1002/14651858.CD010245.pub2]
52. Ramstrom G, Blomback M, Egberg N, Johnsson H, Ljungberg B, Schulman S. Oral surgery in patients with hereditary bleeding disorders. A survey of treatment in the Stockholm area (1974-1985). International Journal of Oral & Maxillofacial Surgery 1989;18(6):320-2.
53. Thomson. Reference Manager®. Version 11. New York: Thomson, 2005.
54. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
55. Rodeghiero F, Castaman G, Dini E. Epidemiological investigation of the prevalence of von Willebrand's disease. Blood 1987;69:454-459.
56. Shira RB. Epsilon aminocaproic acid in hemophiliacs undergoing dental extractions: a concise review. Oral Surgery 1981;51(2):115-20.
57. Sindet-Pedersen S, Ramstrom G, Bernvil S, Blomback M. Hemostatic effect of tranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery. New England Journal of Medicine 1989;320(13):840-3.
58. Sindet-Pedersen S, Gram J, Jespersen J. The possible role of oral epithelial cells in tissue-type plasminogen activator-related fibrinolysis in human saliva. Journal of Dental Research 1990;69(6):1283-6.
59. Stonebraker JS, Bolton-Maggs PH, Soucie JM, Walker I, Brooker M. A study of variations in the reported haemophilia A prevalence around the world. Haemophilia 2010;16(1):20-32.
60. World Federation of Hemophilia. Guidelines for the management of hemophilia, 2nd edition. http://www1.wfh.org/publication/files/pdf-1472.pdf accessed 17 December 2015.