Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model

Genetics and Molecular Research

Volumn 14, Issue 2, 2015, Pages 5642-5651

  Gui, Q F ^a   Lu, H F ^a   Zhang, C X ^a   Xu, Z R ^a   Yang, Y M ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cisplatin; Immune response; Lactobacillus; Lung cancer

Indexed keywords

AMPICILLIN; CISPLATIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GZMB PROTEIN; MEMBRANE PROTEIN; NEOMYCIN; PRF1 PROTEIN; PROBIOTIC AGENT; PROTEIN BAX; UNCLASSIFIED DRUG; VANCOMYCIN; VEGFA PROTEIN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER SIZE; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; IMMUNOMODULATION; INTESTINE FLORA; LACTOBACILLUS ACIDOPHILUS; LEWIS LUNG CARCINOMA CELL; LUNG CANCER; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SURVIVAL RATE; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; DISEASE MODEL; DRUG EFFECTS; GENETICS; HUMAN; INFLAMMATION; LACTOBACILLUS; LUNG NEOPLASMS; MICROBIOLOGY; MICROFLORA; PATHOGENICITY;

AMPICILLIN; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CISPLATIN; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; LACTOBACILLUS; LUNG NEOPLASMS; MICE; MICROBIOTA; NEOMYCIN; NEOPLASM PROTEINS; PROBIOTICS; VANCOMYCIN;

EID: 84965180575     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2015.May.25.16     Document Type: Article

References (11)

1. Hijová E, Bomba A, Bertková I, Strojný L, et al. (2012). Prebiotics and bioactive natural substances induce changes of composition and metabolic activities of the colonic microflora in cancerous rats. Acta Biochim. Pol. 59: 271-274.
2. Iida N, Dzutsev A, Stewart CA, Smith L, et al. (2013). Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 342: 967-970.
3. Kalliomäki M and Isolauri E (2003). Role of intestinal flora in the development of allergy. Curr. Opin. Allergy Clin. Immunol. 3: 15-20.
4. Lax AJ (2005). Opinion: Bacterial toxins and cancer - a case to answer? Nat. Rev. Microbiol. 3: 343-349.
5. Lee YK and Mazmanian SK (2010). Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 330: 1768-1773.
6. Liong MT (2008). Roles of probiotics and prebiotics in colon cancer prevention: Postulated mechanisms and in-vivo evidence. Int. J. Mol. Sci. 9: 854-863.
7. Maroof H, Hassan ZM, Mobarez AM and Mohamadabadi MA (2012). Lactobacillus acidophilus could modulate the immune response against breast cancer in murine model. J. Clin. Immunol. 32: 1353-1359.
8. Miller YE (2005). Pathogenesis of lung cancer: 100 year report. Am. J. Respir. Cell. Mol. Biol. 33: 216-223.
9. Stephani J, Radulovic K and Niess JH (2011). Gut microbiota, probiotics and inflammatory bowel disease. Arch. Immunol. Ther. Exp. 59: 161-177.
10. Waris G and Ahsan H (2006). Reactive oxygen species: role in the development of cancer and various chronic conditions. J. Carcinog. 5: 14.
11. Zarei S, Schwenter F, Luy P, Aurrand-Lions M, et al. (2009). Role of GM-CSF signaling in cell-based tumor immunization. Blood 113: 6658-6668.