Phenotype and cell proliferation activity of ductlike structures in human sublingual glands: A histological and immunohistochemical study

Journal of Applied Oral Science

Volumn 23, Issue 3, 2015, Pages 249-254

  Tolentino, Elen de Souza ^a   Teixeira, Cleverson Soares ^b   Azevedo Alanis, Luciana Reis ^c   Honório, Heitor Marques ^d   Damante, José Humberto ^d  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b INSTITUTO LAURO DE SOUZA LIMA   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aging; Histology; Immunohistochemistry; Salivary ducts; Sublingual gland

Indexed keywords

BIOLOGICAL MARKER; CYTOKERATIN 19; PROTEIN S 100;

ACINAR CELL; ADOLESCENT; ADULT; AGE; AGED; CADAVER; CELL COUNT; CELL PROLIFERATION; CHILD; CYTOLOGY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MIDDLE AGED; NEWBORN; NONPARAMETRIC TEST; PHENOTYPE; PHYSIOLOGY; PRESCHOOL CHILD; REFERENCE VALUE; SALIVARY GLAND DUCT; STAINING; SUBLINGUAL GLAND; VERY ELDERLY; YOUNG ADULT;

ACINAR CELLS; ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BIOMARKERS; CADAVER; CELL COUNT; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INFANT, NEWBORN; KERATIN-19; MALE; MIDDLE AGED; PHENOTYPE; REFERENCE VALUES; S100 PROTEINS; SALIVARY DUCTS; STAINING AND LABELING; STATISTICS, NONPARAMETRIC; SUBLINGUAL GLAND; YOUNG ADULT;

EID: 84965089287     PISSN: 16787757     EISSN: 16787765     Source Type: Journal    
DOI: 10.1590/1678-775720140449     Document Type: Article

References (30)

1. Araújo VC, Sousa SO, Carvalho YR, Araújo NS. Application of immunohistochemistry to the diagnosis of salivary gland tumors. Appl Immunohistochem Mol Morphol. 2000;8(3):195-202.
2. Azevedo LR, Damante JH, Lara VS, Lauris JRP. Age-relates changes in human salivary glands: a post mortem study. Arch Oral Biol. 2005;50(6):565-74.
3. Born IA, Schwechheimer K, Maier H, Otto HF. Cytokeratin expression in normal salivary glands and in cystadenolymphomas demonstrated by monoclonal antibodies against selective cytokeratin polypeptides. Virchows Arch A Pathol Anat Histopathol. 1987;411(6):583-9.
4. Brown DC, Gatter KC. Monoclonal antibody Ki-67: its use in histopathology. Histopathology. 1990;17(6):489-503.
5. Burford-Mason AP, Cummins MM, Brown DH, MacKay AJ, Dardick I. Immunohistochemical analysis of the proliferative capacity of duct and acinar cells during ligation induced atrophy and subsequent regeneration of rat parotid gland. J Oral Pathol Med. 1993;22(10):440-6.
6. Dayan D, Vered M, Paz T, Buchner A. Aging of human palatal salivary glands: a histomorphometric study. Exp Gerontol. 2000;35(1):85-93.
7. Dayan D, Vered M, Sivor S, Hiss Y, Buchner A. Age-related changes in proliferative markers in labial salivary glands: a study of argyrophilic nucleolar organizer regions (AgNORs) and Ki-67. Exp Gerontol. 2002;37(6):841-50.
8. De Wilde PC, Baak JP, van Houwelingen JC, Karter L, Slootweg PJ. Morphometric study of histological changes in sublabial salivary glands due to age process. J Clin Pathol. 1986;39(4):406-17.
9. Drummond JR, Chisholm DM. A qualitative and quantitative study of the ageing human labial salivary glands. Arch Oral Biol. 1984;29(2):151-5.
10. Geiger S, Geiger B, Leitner O, Marshak J. Cytokeratin polypeptides expression in different epithelial elements of human salivary glands. Virshows Arch A Pathol Anat Histopathol. 1987;410(5):403-14.
11. Gerdes J, Becker MH, Key G, Cattoretti G. Immunohistological detection of tumor growth fraction (Ki-67 antigen) in formalin fixed and routinely tissues. J Pathol. 1992;168(1):85-6.
12. Goulart MC, Freitas-Faria P, Goulart GR, Oliveira AM, Carlos. Bregni R, Soares CT, et al. Pleomorphic adenoma with extensive squamous metaplasia and keratin cyst formations in minor salivary gland: a case report. J Appl Oral Sci. 2011;19(2):182-8.
13. Ihrler S, Zietz C, Sendelhofert A, Lang S, Blasenbreu-Vogt S, Löhrs U. A morphogenetic concept of salivary duct regeneration and metaplasia. Virchows Arch. 2002;440(5):519-26.
14. Iwaki Filho L, Damante JH, Consolaro A, Bonachela WC, Damante CA. Mouth floor enlargements related to the sublingual glands in edentulous or partially edentulous patients: a microscopic study. J Appl Oral Sci. 2006;14(4):264-9.
15. Maria OM, Maria SM, Redman RS, Maria AM, Saad El-Din TA, Soussa EF, et al. Effects of double ligation of Stensen's duct on the rabbit parotid gland. Biotech Histochem. 2014;89(3):181-98.
16. Marshak G, Leitner O. Cytokeratin polypeptides in normal and metaplastic human salivary gland epithelia. J Oral Pathol. 1987;16(9):442-9.
17. Mintz GA, Mooradian AD. Age-related changes in rat sublingual salivary gland morphology. Gerodontol. 1987;6(4):137-44.
18. Moreira CR, Azevedo LR, Lauris JRP, Taga R, Damante JH. Quantitative age. related differences in human sublingual gland. Arch Oral Biol. 2006;51(11):960-6.
19. Nakazato Y, Ishida Y, Takahashi K, Suzuki K. Immunohistochemical distribution of S-100 protein and glial fibrillary acidic protein in normal and neoplastic salivary glands. Virchows Arch A Pathol Anat Histopathol. 1985;405(3):299-310.
20. Nery LR, Moreira CR, Cestari TM, Taga R, Damante JH. Postmortem acinar autolysis in rat sublingual gland: a morphometric study. J Appl Oral Sci. 2010;18(5):509-14.
21. Ninomiya T, Naito R, Okada Y, Kobayashi K, Mori M, Tsukitani K. Immunohistochemical localization of the alpha and beta subunits of S-100 protein in pleomorphic adenoma of the salivary glands. Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;57(1):63-75.
22. Sá JC, Tolentino ES, Azevedo-Alanis LR, Iwaki-Filho L, Lara VS, Damante JH. Morphology and morphometry of the human sublingual glands in mouth floor enlargements of edentulous patients. J Appl Oral Sci. 2013;21(6):540-6.
23. Scott J. Quantitative age changes in the histological structure of human submandibular salivary glands. Arch Oral Biol. 1977;22(3):221-7.
24. Scott J, Bodner L, Baum BJ. Assessment of age-related changes in the submandibular and sublingual salivary glands of the rat using stereological analysis. Short communication. Arch Oral Biol. 1986;31(1):69-71.
25. Scott J, Flower EA, Burns J. A quantitative study of histological changes in the human parotid gland occurring with adult age. J Oral Pathol. 1987;16(10):505-10.
26. Soini Y, Puhakka A, Kahlos K, Säily M, Pääkkö P, Koistinen P, et al. Endothelial nitric oxide synthase is strongly expressed in malignant mesothelioma but does not associate with vascular density or the expression of VEGF, FLK1 or FLT1. Histopathology. 2001;39(2):179-86.
27. Sørensen CE, Larsen JO, Reibel J, Lauritzen M, Mortensen EL, Osler M, et al. Associations between xerostomia, histopathological alterations, and autonomic innervation of labial salivary glands in men in late midlife. Exp Gerontol. 2014;57:211-7.
28. Takahashi S, Shinzato K, Nakamura S, Domon T, Yamamoto T, Wakita M. The roles of apoptosis and mitosis in atrophy of the rat sublingual gland. TissueCell. 2002;34(5):297-304.
29. Vered M, Buchner A, Boldon P, Dayan D. Age-related histomorphometric changes in labial salivary glands with special reference to the acinar component. Exp Gerontol. 2000;35:1075. 84.
30. Waterhouse JP, Chisholm DM, Winter RB, Patel M, Yale RS. Replacement of functional parenchymal cells by fat and connective tissue in human submandibular salivary glands: an age-related change. J Oral Pathol. 1973;2(1):16-27.