Hepatitis C virus core protein enhances hepatocellular carcinoma cells to be susceptible to oncolytic vesicular stomatitis virus through down-regulation of HDAC4

Biochemical and Biophysical Research Communications

Volumn 474, Issue 3, 2016, Pages 428-434

  Moon, Jeong ^a   Kaowinn, Sirichat ^a   Cho, Il Rae ^a   Min, Do Sik ^a   Myung, Heejoon ^b   Oh, Sangtaek ^c   Kaewpiboon, Chutima ^d   Kraemer, Olive H ^e   Chung, Young Hwa ^a  

^a Pusan National University   (South Korea)

^b Hankuk University of Foreign Studies   (South Korea)

^c Kookmin University   (South Korea)

^d Thakshin University   (Thailand)

^e FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Acetylation; HDAC4; Phosphorylation; STAT1; Virotherapy; VSV

Indexed keywords

ALPHA INTERFERON; CORE PROTEIN; HEPATITIS C VIRUS CORE PROTEIN; HISTONE DEACETYLASE 4; JANUS KINASE 1; PROTEIN KINASE TYK2; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG; HDAC4 PROTEIN, HUMAN; HISTONE DEACETYLASE; ONCOLYTIC VIRUS; REPRESSOR PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOLYSIS; DOWN REGULATION; HEPATOCELLULAR CARCINOMA CELL LINE; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; VESICULOVIRUS; VIRUS REPLICATION; CARCINOMA, HEPATOCELLULAR; HEPATITIS C; HUMAN; METABOLISM; ONCOLYTIC VIROTHERAPY; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME; TUMOR CELL LINE; VESICULAR STOMATITIS; VIROLOGY;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DOWN-REGULATION; HEPATITIS C; HISTONE DEACETYLASES; HUMANS; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; REPRESSOR PROTEINS; TREATMENT OUTCOME; VESICULAR STOMATITIS; VESICULOVIRUS; VIRAL CORE PROTEINS;

EID: 84965082697     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.05.005     Document Type: Article

References (36)

1. A. Grakoui, C. Wychowski, C. Lin, S.M. Feinstone, and C.M. Rice Expression and identification of hepatitis C virus polyprotein cleavage products J. Virol. 67 1993 1385 1395
2. I. Saito, T. Miyamura, A. Ohbayashi, and et al. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma Proc. Natl. Acad. Sci. U. S. A. 87 1990 6547 6549
3. S.W. Jeong, J.Y. Jang, and R.T. Chung Hepatitis C virus and hepatocarcinogenesis Clin. Mol. Hepatology 18 2012 347 356
4. L.R. You, C.M. Chen, and Y.H. Lee Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha J. Virol. 73 1999 1672 1681
5. T. Tsutsumi, T. Suzuki, K. Moriya, and et al. Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice Hepatology 38 2003 820 828
6. J. Liu, X. Ding, J. Tang, and et al. Enhancement of canonical Wnt/beta-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells PLoS One 6 2011 e27496
7. K. Matsuzaki, M. Murata, K. Yoshida, and et al. Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma Hepatology 46 2007 48 57
8. A. Spaziani, A. Alisi, D. Sanna, and C. Balsano Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1 J. Biol. Chem. 281 2006 10983 10989
9. K. Moriya, H. Fujie, Y. Shintani, and et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice Nat. Med. 4 1998 1065 1067
10. T. Yoshida, T. Hanada, T. Tokuhisa, and et al. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation J. Exp. Med. 196 2002 641 653
11. G.R. Stark, I.M. Kerr, B.R. Williams, R.H. Silverman, and R.D. Schreiber How cells respond to interferons Annu. Rev. Biochem. 67 1998 227 264
12. T. Ginter, C. Bier, S.K. Knauer, and et al. Histone deacetylase inhibitors block IFNgamma-induced STAT1 phosphorylation Cell. Signal. 24 2012 1453 1460
13. O.H. Kramer, S.K. Knauer, G. Greiner, and et al. A phosphorylation-acetylation switch regulates STAT1 signaling Genes Dev. 23 2009 223 235
14. L. Klampfer, J. Huang, T. Sasazuki, S. Shirasawa, and L. Augenlicht Inhibition of interferon gamma signaling by the short chain fatty acid butyrate. Molecular cancer research MCR 1 2003 855 862
15. H.M. Chang, M. Paulson, M. Holko, and et al. Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity Proc. Natl. Acad. Sci. U. S. A. 101 2004 9578 9583
16. L. Klampfer, J. Huang, L.A. Swaby, and L. Augenlicht Requirement of histone deacetylase activity for signaling by STAT1 J. Biol. Chem. 279 2004 30358 30368
17. C. de Mattos, C.C. de Mattos, and C.E. Rupprecht Rhabdoviridae: the viruses and their replication 2001 Lippincott Williams and Wilkins New York
18. J.R. Bischoff, D.H. Kirn, A. Williams, and et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells Science 274 1996 373 376
19. M.C. Coffey, J.E. Strong, P.A. Forsyth, and P.W. Lee Reovirus therapy of tumors with activated Ras pathway Science 282 1998 1332 1334
20. S. Varghese, and S.D. Rabkin Oncolytic herpes simplex virus vectors for cancer virotherapy Cancer Gene Ther. 9 2002 967 978
21. D.F. Stojdl, B. Lichty, S. Knowles, and et al. Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus Nat. Med. 6 2000 821 825
22. M. Fernandez, M. Porosnicu, D. Markovic, and G.N. Barber Genetically engineered vesicular stomatitis virus in gene therapy: application for treatment of malignant disease J. Virol. 76 2002 895 904
23. S. Leveille, S. Samuel, M.L. Goulet, and J. Hiscott Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy Cancer Gene Ther. 18 2011 435 443
24. Q. Li, and M.A. Tainsky Epigenetic silencing of IRF7 and/or IRF5 in lung cancer cells leads to increased sensitivity to oncolytic viruses PLoS One 6 2011 e28683
25. K.B. Stephenson, N.G. Barra, E. Davies, A.A. Ashkar, and B.D. Lichty Expressing human interleukin-15 from oncolytic vesicular stomatitis virus improves survival in a murine metastatic colon adenocarcinoma model through the enhancement of anti-tumor immunity Cancer Gene Ther. 19 2012 238 246
26. M. Porosnicu, A. Mian, and G.N. Barber The oncolytic effect of recombinant vesicular stomatitis virus is enhanced by expression of the fusion cytosine deaminase/uracil phosphoribosyltransferase suicide gene Cancer Res. 63 2003 8366 8376
27. O.H. Kramer, and T. Heinzel Phosphorylation-acetylation switch in the regulation of STAT1 signaling Mol. Cell. Endocrinol. 315 2010 40 48
28. L. Icardi, K. De Bosscher, and J. Tavernier The HAT/HDAC interplay: multilevel control of STAT signaling Cytokine Growth Factor Rev. 23 2012 283 291
29. W. Lin, S.S. Kim, E. Yeung, and et al. Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain J. Virol. 80 2006 9226 9235
30. J. Vlasakova, Z. Novakova, L. Rossmeislova, M. Kahle, P. Hozak, and Z. Hodny Histone deacetylase inhibitors suppress IFNalpha-induced up-regulation of promyelocytic leukemia protein Blood 109 2007 1373 1380
31. I. Nusinzon, and C.M. Horvath Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1 Proc. Natl. Acad. Sci. U. S. A. 100 2003 14742 14747
32. S. Sakamoto, R. Potla, and A.C. Larner Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes J. Biol. Chem. 279 2004 40362 40367
33. H. Geng, C.T. Harvey, J. Pittsenbarger, and et al. HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia J. Biol. Chem. 286 2011 38095 38102
34. M.M. Mihaylova, D.S. Vasquez, K. Ravnskjaer, and et al. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis Cell 145 2011 607 621
35. E.A. Stronach, A. Alfraidi, N. Rama, and et al. HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer Cancer Res. 71 2011 4412 4422
36. J.M. Bodily, K.P. Mehta, and L.A. Laimins Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases Cancer Res. 71 2011 1187 1195