Systematic Investigation of EDC/sNHS-Mediated Bioconjugation Reactions for Carboxylated Peptide Substrates

Bioconjugate Chemistry

Volumn 27, Issue 4, 2016, Pages 994-1004

  Totaro, Kyle A ^a   Liao, Xiaoli ^a   Bhattacharya, Keshab ^b   Finneman, Jari I ^b   Sperry, Justin B ^b   Massa, Mark A ^b   Thorn, Jennifer ^b   Ho, Sa V ^c   Pentelute, Bradley L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b PFIZER INC   (United States)

^c Pfizer Global Research and Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1-ETHYL-3-(3-DIMETHYLAMINO-PROPYL) CARBODIIMIDE; AQUEOUS APPLICATIONS; BIO-CONJUGATION; CONDITION; MEDICAL RESEARCH; MODEL PEPTIDES; PEPTIDE PROTEINS; PEPTIDE SUBSTRATES; PRODUCT FORMATION; SIDE REACTIONS;

PEPTIDES;

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE; 2 (2 PYRIDYL)ETHYLAMINE; AMINE; N HYDROXYSULFOSUCCINIMIDE; NUCLEOPHILE; PEPTIDE; REAGENT; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG; 1-ETHYL-3-(3-(DIETHYLAMINO)PROPYL)CARBODIIMIDE; CYANAMIDE;

ARTICLE; BIOCONJUGATION; CARBOXYLATION; CONCENTRATION (PARAMETERS); CONJUGATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; PH; STOICHIOMETRY; SYNTHESIS; CHEMISTRY; ENZYME SPECIFICITY;

CARBODIIMIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PEPTIDES; SUBSTRATE SPECIFICITY;

EID: 84965081955     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/acs.bioconjchem.6b00043     Document Type: Article

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