Central role for marginal zone B cells in an animal model of Sjogren's syndrome

Clinical Immunology

Volumn 168, Issue , 2016, Pages 30-36

  Shen, Long ^a   Gao, Chun ^a,b   Suresh, Lakshmanan ^c   Xian, Zhenhua ^b   Song, Nannan ^b   Chaves, Lee D ^a   Yu, Meixing ^a   Ambrus, Julian L ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AUTOANTIBODY; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 14; INTERLEUKIN 14 ALPHA; INTERLEUKIN 6; MESSENGER RNA; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE; TXLNA PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE CLEARANCE; GENE EXPRESSION; HISTOLOGY; IMMUNOPATHOGENESIS; INNATE IMMUNITY; LACRIMAL GLAND; LYMPHOCYTE FUNCTION; MARGINAL ZONE B CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; SALIVARY GLAND FUNCTION; SALIVATION; SJOEGREN SYNDROME; SPLEEN CELL; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LACRIMAL APPARATUS; METABOLISM; SALIVARY GLAND;

ANIMALS; AUTOANTIBODIES; B-LYMPHOCYTES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IMMUNITY, INNATE; INTERLEUKINS; LACRIMAL APPARATUS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; SALIVARY GLANDS; SJOGREN'S SYNDROME;

EID: 84965029194     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2016.04.008     Document Type: Article

References (36)

1. Garcia Carrasco M., Ramos Casals M., Rosas J., Pallares L., CalvoAlen J., Cervera R., Font J., Ingelmo M. Primary Sjogren syndrome - clinical and immunologic disease patterns in a cohort of 400 patients. Medicine 2002, 81:270-280.
2. Fox R.I. Sjogren's syndrome. Lancet 2005, 366:321-331.
3. Jonsson R., Nginamau E., Szyszko E., Brokstad K.A. Role of B cells in Sjogren's syndrome - from benign lymphoproliferation to overt malignancy. Front. Biosci. 2007, 12:2159-2170.
4. Kroese F.G.M., Abdulahad W.H., Haacke E., Bos N.A., Vissink A., Bootsma H. B-cell hyperactivity in primary Sjogren's syndrome. Expert. Rev. Clin. Immunol. 2014, 10:483-499.
5. Pers J.O., Youinou P. Are the B cells cast with the leading part in the Sjogren's syndrome scenario?. Oral Dis. 2014, 20:529-537.
6. Daridon C., Pers J.O., Devauchelle V., MartinsCarvalho C., Hutin P., Pennec Y.L., Saraux A., Youinou P. Identification of transitional type IIB cells in the salivary glands of patients with Sjogren's syndrome. Arthritis Rheum. 2006, 54:2280-2288.
7. Vossenkamper A., Lutalo P.M.K., Spencer J. Translational mini-review series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjogren's syndrome: clinical implications and effects of B cell-targeted therapies. Clin. Exp. Immunol. 2012, 167:7-14.
8. Fletcher C.A., Sutherland A.P., Groom J.R., Batten M.L., Ng L.G., Gommerman J., Mackay F. Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells. Eur. J. Immunol. 2006, 36:2504-2514.
9. Shen L., Suresh L., Li H., Zhang C., Kumar V., Pankewycz O., Ambrus J.J. IL-14alpha, the nexus for primary Sjogren's disease in mice and humans. Clin. Immunol. 2009, 130:304-312.
10. Shen L., Suresh L., Wu J., Xuan J.X., Li H., Zhang C.J., Pankewycz O., Ambrus J.L. A role for lymphotoxin in primary Sjogren's disease. J. Immunol. 2010, 185:6355-6363.
11. Shen L., Suresh L., Lindemann M., Xuan J., Kowal P., Malyavantham K., Ambrus J.L. Novel autoantibodies in Sjogren's syndrome. Clin. Immunol. 2012, 145:251-255.
12. Shen L., Suresh L., Malyavantham K., Kowal P., Xuan J.X., Lindemann M.J., Ambrus J.L. Different stages of primary Sjogren's syndrome involving lymphotoxin and type 1 IFN. J. Immunol. 2013, 191:608-613.
13. Tanigaki K., Han H., Yamamoto N., Tashiro K., Ikegawa M., Kuroda K., Suzuki A., Nakano T., Honjo T. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat. Immunol. 2002, 3:443-450.
14. Khan W.N., Alt F.W., Gerstein R.M., Malynn B.A., Larsson I., Rathbun G., Davidson L., Muller S., Kantor A.B., Herzenberg L.A., et al. Defective B cell development and function in btk-deficient mice. Immunity 1995, 3:283-299.
15. Shen, L., C. Zhang, T. Wang, S. Brooks, R. J. Ford, Y. C. Lin-Lee, A. Kasianowicz, V. Kumar, L. Martin, P. Liang, J. Cowell, and J. Ambrus, JL. 2006. Development of autoimmunity in interleukin-14alpha transgenic mice. J. Immunol. 177: 5676-5686.
16. Shen L., Suresh L., Wu J., Jingxiu X., Li H., Zhang C., Pankewycz O., Ambrus J.J. A role for lymphotoxin in primary Sjogren's disease. J. Immunol. 2010, 185:6355-6363.
17. Tanigaki K., Honjo T. Regulation of lymphocyte development by notch signaling. Nat. Immunol. 2007, 8:451-456.
18. Xuan J.X., Shen L., Malyavantham K., Pankewycz O., Ambrus J.L., Suresh L. Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren's syndrome. BMC Oral Health 2013, 13.
19. Pillai S., Cariappa A., Moran S.T. Marginal zone B cells. Annu. Rev. Immunol. 2005, 23:161-196.
20. Allam R., Anders H.J. The role of innate immunity in autoimmune tissue injury. Curr. Opin. Rheumatol. 2008, 20:538-544.
21. Lehuen A., Diana J., Zaccone P., Cooke A. Immune cell crosstalk in type 1 diabetes. Nat. Rev. Immunol. 2010, 10:501-513.
22. Nikolov N.P., Illei G.G. Pathogenesis of Sjogren's syndrome. Curr. Opin. Rheumatol. 2009, 21:465-470.
23. Donate A., Voigt A., Nguyen C.Q. The value of animal models to study immunopathology of primary human Sjogren's syndrome symptoms. Expert. Rev. Clin. Immunol. 2014, 10:469-481.
24. Woods K.M., Pope M.R., Hoffman S.M., Fleming S.D. CR2(+) marginal zone B cell production of pathogenic natural antibodies is C3 independent. J. Immunol. 2011, 186:1755-1762.
25. You Y., Myers R.C., Freeberg L., Foote J., Kearney J.F., Justement L.B., Carter R.H. Marginal zone B cells regulate antigen capture by marginal zone macrophages. J. Immunol. 2011, 186:2172-2181.
26. Weill J.C., Weller S., Reynaud C.A. Human marginal zone B cells. Annu. Rev. Immunol. 2009, 27:267-285.
27. Weller S., Braun M.C., Tan B.K., Rosenwald A., Cordier C., Conley M.E., Plebani A., Kumararatne D.S., Bonnet D., Tournilhac O., Tchernia G., Steiniger B., Staudt L.M., Casanova J.L., Reynaud C.A., Weill J.C. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004, 104:3647-3654.
28. Li H., Jiang Y., Prak E.L., Radic M., Weigert M. Editors and editing of anti-DNA receptors. Immunity 2001, 15:947-957.
29. Le Pottier L., Devauchelle V., Fautrel A., Daridon C., Saraux A., Youinou P., Pers J.O. Ectopic germinal centers are rare in Sjogren's syndrome salivary glands and do not exclude autoreactive B cells. J. Immunol. 2009, 182:3540-3547.
30. Attanavanich K., Kearney J.F. Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells. J. Immunol. 2004, 172:803-811.
31. Jamin C., Morva A., Lemoine S., Daridon C., de Mendoza A.R., Youinou P. Regulatory B lymphocytes in humans - a potential role in autoimmunity. Arthritis Rheum. 2008, 58:1900-1906.
32. Mariette X. Therapeutic potential for B-cell modulation in Sjogren's syndrome. Rheum. Dis. Clin. N. Am. 2008, 34. (1025-+).
33. Youinou P., Devauchelle V., Hutin P., Le Berre R., Saraux A., Pers J.O. A conspicuous role for B cells in Sjogren's syndrome. Clin. Rev. Allergy Immunol. 2007, 32:231-237.
34. Alcantara C., Gomes M.J., Ferreira C. Rituximab therapy in primary Sjogren's syndrome. Contemporary Challenges in Autoimmunity 2009, 701-705. Y. Shoenfeld, M.E. Gershwin (Eds.).
35. Pijpe J., vanImhoff G.W., Spijkervet F.K.L., Roodenburg J.L.N., Wolbink G.J., Mansour K., Vissink A., Kallenberg C.G.M., Bootsma H. Rituximab treatment in patients with primary Sjogren's syndrome. Arthritis Rheum. 2005, 52:2740-2750.
36. Mackay F., Woodcock S.A., Lawton P., Ambrose C., Baetscher M., Schneider P., Tschopp J., Browning J.L. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 1999, 190:1697-1710.