A morphological and immunophenotypic map of the immune response in Merkel cell carcinoma

Human Pathology

Volumn 52, Issue , 2016, Pages 190-196

  Walsh, Noreen M ^a,b   Fleming, Kirsten E ^a,b   Hanly, John G ^a,b   Dakin Hache, Kelly ^a,b   Doucette, Steve ^b,c   Ferrara, Gerardo ^d,e   Cerroni, Lorenzo ^e  

^a QUEEN ELIZABETH II HEALTH SCIENCES CENTRE   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c DALHOUSIE UNIVERSITY   (Canada)

^d G RUMMO HOSPITAL   (Italy)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Antitumoral immunity; Cutaneous neuroendocrine carcinoma; Merkel cell carcinoma; PD 1 PD L1 pathway; TILS; Tumor infiltrating lymphocytes; Tumor specific CD8 + T cells

Indexed keywords

CD123 ANTIGEN; CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; PROGRAMMED DEATH 1 LIGAND 1; TRANSCRIPTION FACTOR FOXP3; TUMOR MARKER;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITY; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MERKEL CELL POLYOMAVIRUS; MERKEL CELL TUMOR; MORTALITY; REGULATORY T LYMPHOCYTE; TUMOR REGRESSION; CHEMISTRY; HOST PATHOGEN INTERACTION; IMMUNOLOGY; IMMUNOTHERAPY; LYMPHOCYTE COUNT; MERKEL CELL CARCINOMA; MIDDLE AGED; PATHOLOGY; PHENOTYPE; PROCEDURES; SKIN TUMOR; TUMOR ASSOCIATED LEUKOCYTE; TUMOR ESCAPE; TUMOR MICROENVIRONMENT; VERY ELDERLY; VIROLOGY;

AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; CARCINOMA, MERKEL CELL; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IMMUNOTHERAPY; LYMPHOCYTE COUNT; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MERKEL CELL POLYOMAVIRUS; MIDDLE AGED; PHENOTYPE; SKIN NEOPLASMS; T-LYMPHOCYTES, REGULATORY; TUMOR ESCAPE; TUMOR MICROENVIRONMENT;

EID: 84964989111     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2016.02.002     Document Type: Article

References (24)

1. S. Hadrup, M. Donia, and P. Thor Straten Effector CD4 and CD8 T cells and their role in the tumor microenvironment Cancer Microenviron 6 2013 123 133
2. A.S. Berghoff, G. Ricken, G. Widhalm, and et al. Tumour-infiltrating lymphocytes and expression of programmed death ligand 1 (PD-L1) in melanoma brain metastases Histopathology 66 2015 289 299
3. M. Sznol, and D.L. Longo Release the hounds! activating the T-cell response to cancer. Editorial N Engl J Med 372 2015 374 375
4. K.G. Paulson, J.G. Iyer, A. Blom, and et al. Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage J Invest Dermatol 133 2013 642 646
5. H. Feng, M. Shuda, Y. Chang, and et al. Clonal integration of a polyomavirus in human Merkel cell carcinoma Science 319 2008 1096 1100
6. J.C. Wooff, J.R. Trites, N.M.G. Walsh, and M.J. Bullock Complete spontaneous regression of metastatic Merkel cell carcinoma: a case report and review of the literature Am J Dermatopathol 32 2010 614 617
7. H. Sihto, T. Böhling, H. Kavola, and et al. Tumor infiltrating immune cells and outcome of Merkel cell carcinoma: a population-based study Clin Cancer Res 18 2012 2872 2881
8. H. Sihto, H. Kukko, V. Koljonen, R. Sankila, T. Böhling, and H. Joensuu Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma J Natl Cancer Inst 101 2009 938 945
9. K.G. Paulson, J.G. Iyer, A.R. Tegeder, and et al. Transcriptome-wide studies of Merkel cell carcinoma and validation of intratumoral CD8 + lymphocyte invasion as an independent predictor of survival J Clin Oncol 29 2011 1539 1546
10. K.G. Paulson, J.G. Iyer, W.T. Simonson, and et al. CD8 + lymphocyte intratumoral infiltration as a stage-independent predictor of Merkel cell carcinoma survival. A population-based study Am J Clin Pathol 142 2014 452 458
11. M. Dowlatshahi, V. Huang, A.E. Gehad, and et al. Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T-cell exhaustion in reducing T-cell responses J Invest Dermatol 133 2013 1879 1889
12. E.J. Lipson, J.G. Vincent, M. Loyo, and et al. PD-L1 expression in the Merkel cell carcinoma microenvironment: association with inflammation, Merkel cell polyomavirus and overall survival Cancer Immunol Res 1 2013 54 63
13. O.K. Afanasiev, L. Yelistratova, N. Miller, and et al. Merkel polyomavirus-specific T cells fluctuate with Merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers Clin Cancer Res 19 2013 5351 5360
14. N.M.G. Walsh Primary neuroendocrine (Merkel cell) carcinoma of the skin: morphologic diversity and implications thereof Hum Pathol 32 2001 680 689
15. T.Y. Ly, N.M. Walsh, and S. Pasternak The spectrum of Merkel cell polyomavirus expression in Merkel cell carcinoma, in a variety of cutaneous neoplasms, and in neuroendocrine carcinomas from different anatomical sites Hum Pathol 43 2012 557 566
16. K.E. Fleming, T.Y. Ly, S. Pasternak, M. Godlewski, S. Doucette, and N.M. Walsh Support for p63 expression as an adverse prognostic marker in Merkel cell carcinoma: report on a Canadian cohort Hum Pathol 45 2014 952 960
17. J.H. Lai, K.E. Fleming, T.Y. Ly, and et al. Pure versus combined Merkel cell carcinomas: immunohistochemical evaluation of cellular proteins (p53, bcl-2, and c-kit) reveals significant overexpression of p53 in combined tumors Hum Pathol 46 2015 1290 1296
18. P. Rao, B.L. Balzer, B.D. Lemos, and et al. Protocol for the examination of specimens from patients with Merkel cell carcinoma of the skin Arch Pathol Lab Med 134 2010 341 344
19. G.P. Dunn, L.J. Old, and R.D. Schreiber The three Es of cancer immunoediting Annu Rev Immunol 22 2004 329 360
20. G. Rabinowits Systemic therapy for Merkel cell carcinoma: What's on the horizon? Cancers 6 2014 1180 1194
21. A.G. Chapuis, O.K. Afanasiev, J.G. Iyer, and et al. Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of reinducing HLA Class-I Cancer Immunol Res 2 2014 27 36
22. S. Wei, I. Kryczek, L. Zou, and et al. Plasmacytoid dendritic cells induce CD8 + regulatory T cells in human ovarian carcinoma Cancer Res 65 2005 5020 5026
23. K.G. Paulson, J.J. Carter, L.G. Johnson, and et al. Antibodies to Merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in Merkel cell carcinoma patients Cancer Res 70 2010 8388 8397
24. S.C. Jansen, C.P. Groeneveld-Haenen, P.J. Klinkhamer, and R.M. Roumen Spontaneous regression and recurrence of stage III Merkel cell carcinoma BMJ Case Rep 2015 10.1136/bcr-2014-208344