Multiplexing high-content flow (HCF) and quantitative high-throughput screening (qHTS) to identify compounds capable of decreasing cell viability, activating caspase 3/7, expressing annexin V, and changing mitochondrial membrane integrity

Current protocols in chemical biology

Volumn 5, Issue 3, 2013, Pages 195-212

  Mathews, Lesley A ^a   Keller, Jonathan M ^a   McKnight, Crystal ^a   Michael, Sam ^a   Shinn, Paul ^a   Liu, Dongbo ^a   Staudt, Louis M ^a   Thomas, Craig J ^a   Ferrer, Marc ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

annexin V; cell viability; high content flow (HCF); lcaspase 3 7; mitochondrial membrane integrity; quantitative high throughput screening (qHTS)

Indexed keywords

CASPASE 3; CASPASE 7; LIPOCORTIN 5;

APOPTOSIS; BIOSYNTHESIS; CELL PROLIFERATION; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE; PROCEDURES;

ANNEXIN A5; APOPTOSIS; CASPASE 3; CASPASE 7; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLOW CYTOMETRY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MITOCHONDRIAL MEMBRANES;

EID: 84964931698     PISSN: None     EISSN: 21604762     Source Type: Journal    
DOI: 10.1002/9780470559277.ch130060     Document Type: Article

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