Use of metformin earlier in pregnancy predicts supplemental insulin therapy in women with gestational diabetes

Diabetes Research and Clinical Practice

Volumn 116, Issue , 2016, Pages 96-99

  McGrath, Rachel T ^a,b   Glastras, Sarah J ^a   Hocking, Samantha ^a,b,c   Fulcher, Gregory R ^a,b  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Gestational diabetes; Glycaemic control; Insulin; Metformin; Perinatal outcomes

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN; METFORMIN; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ADULT; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; INCIDENCE; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MATERNAL AGE; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; COMBINATION DRUG THERAPY; DIABETES, GESTATIONAL; PREGNANCY; RETROSPECTIVE STUDY;

ADULT; BLOOD GLUCOSE; DIABETES, GESTATIONAL; DRUG THERAPY, COMBINATION; FEMALE; GESTATIONAL AGE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; METFORMIN; PREGNANCY; PREGNANCY OUTCOME; RETROSPECTIVE STUDIES;

EID: 84964921004     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2016.04.051     Document Type: Article

References (9)

1. Moses R.G., Barker M., Winter M., Petocz P., Brand-Miller J.C. Can a low-glycemic index diet reduce the need for insulin in gestational diabetes mellitus? A randomized trial. Diabetes Care 2009, 32(6):996-1000.
2. Kitwitee P., Limwattananon S., Limwattananon C., Waleekachonlert O., Ratanachotpanich T., Phimphilai M., et al. Metformin for the treatment of gestational diabetes: an updated meta-analysis. Diabetes Res Clin Pract 2015, 109(3):521-532.
3. Dhulkotia J.S., Ola B., Fraser R., Farrell T. Oral hypoglycemic agents vs insulin in management of gestational diabetes: a systematic review and metaanalysis. Am J Obstet Gynecol 2010, 203(5). 457 e1-9.
4. Rowan J.A., Hague W.M., Gao W., Battin M.R., Moore M.P., Mi G.T.I. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 2008, 358(19):2003-2015.
5. Balani J., Hyer S.L., Rodin D.A., Shehata H. Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study. Diabet Med 2009, 26(8):798-802.
6. Tertti K., Ekblad U., Koskinen P., Vahlberg T., Ronnemaa T. Metformin vs. insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin. Diabetes Obes Metab 2013, 15(3):246-251.
7. Corbould A., Swinton F., Radford A., Campbell J., McBeath S., Dennis A. Fasting blood glucose predicts response to extended-release metformin in gestational diabetes mellitus. Aust N Z J Obstet Gynaecol 2013, 53(2):125-129.
8. Ashoush S., El-Said M., Fathi H., Abdelnaby M. Identification of metformin poor responders, requiring supplemental insulin, during randomization of metformin versus insulin for the control of gestational diabetes mellitus. J Obstet Gynaecol Res 2016.
9. Spaulonci C.P., Bernardes L.S., Trindade T.C., Zugaib M., Francisco R.P. Randomized trial of metformin vs insulin in the management of gestational diabetes. Am J Obstet Gynecol 2013, 209(1). 34 e1-7.