Protein biomarkers of susceptibility and resilience to stress in a rat model of depression

Molecular and Cellular Neuroscience

Volumn 74, Issue , 2016, Pages 87-95

  Palmfeldt, Johan ^a   Henningsen, Kim ^b   Eriksen, Stine Aistrup ^b   Müller, Heidi K ^b   Wiborg, Ove ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Biomarkers; Chronic mild stress model of depression; Glial fibrillary acidic protein; Prefrontal cortex; Synaptosome

Indexed keywords

ATP1A2 PROTEIN; BIOLOGICAL MARKER; PEROXIREDOXIN 1; PEROXIREDOXIN 2; PROTEIN HOMER 1; UNCLASSIFIED DRUG; UQCRC1 PROTEIN; UQCRFS1 PROTEIN; VESICULAR GLUTAMATE TRANSPORTER 1; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); GLIAL FIBRILLARY ACIDIC PROTEIN; HOMER SCAFFOLDING PROTEIN; HOMER1 PROTEIN, MOUSE; PEROXIREDOXIN; PRDX1 PROTEIN, MOUSE; SLC17A7 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; COPING BEHAVIOR; DEPRESSION; DISEASE PREDISPOSITION; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; RAT; SYNAPTOSOME; ANIMAL; GENETICS; MENTAL STRESS; METABOLISM; PREFRONTAL CORTEX; WISTAR RAT;

ANIMALS; BIOMARKERS; DEPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN; HOMER SCAFFOLDING PROTEINS; MALE; PEROXIREDOXINS; PREFRONTAL CORTEX; RATS; RATS, WISTAR; SODIUM-POTASSIUM-EXCHANGING ATPASE; STRESS, PSYCHOLOGICAL; SYNAPTOSOMES; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1;

EID: 84964920954     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2016.04.001     Document Type: Article

References (44)

1. Bai F., Witzmann F.A. Synaptosome proteomics. Subcell. Biochem. 2007, 43:77-98.
2. Banasr, M. and R.S. Duman, Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment.
3. Banasr M., et al. Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol. Psychiatry 2010, 15(5):501-511.
4. Bergstrom A., et al. Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study. Brain Res. 2008, 1196:41-52.
5. Christensen T., Bisgaard C.F., Wiborg O. Biomarkers of anhedonic-like behavior, antidepressant drug refraction, and stress resilience in a rat model of depression. Neuroscience 2011, 196:66-79.
6. Christensen T., et al. Molecular profiling of the lateral habenula in a rat model of depression. PLoS One 2013, 8(12):e80666.
7. Cotter, D., et al., Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder.
8. Dunkley P.R., et al. A rapid method for isolation of synaptosomes on Percoll gradients. Brain Res. 1986, 372(1):115-129.
9. Dunkley P.R., Jarvie P.E., Robinson P.J. A rapid Percoll gradient procedure for preparation of synaptosomes. Nat. Protoc. 2008, 3(11):1718-1728.
10. Henningsen K., et al. Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses. Behav. Brain Res. 2009, 198(1):136-141.
11. Henningsen K., et al. Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression. Mol. Cell. Proteomics 2012, 11(7). M111 016428.
12. Henningsen K., et al. Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression. Behav. Pharmacol. 2012, 23(8):735-743.
13. Hjemdal O., et al. The relationship between resilience and levels of anxiety, depression, and obsessive-compulsive symptoms in adolescents. Clin. Psychol. Psychother. 2010.
14. Huang da W., Sherman B.T., Lempicki R.A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009, 37(1):1-13.
15. Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 2009, 4(1):44-57.
16. Ikeda K., et al. Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2)-deficient mice. J. Neurosci. 2003, 23(11):4667-4676.
17. Johnston-Wilson N.L., et al. Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium. Mol. Psychiatry 2000, 5(2):142-149.
18. Kriaucionis S., et al. Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol. Cell. Biol. 2006, 26(13):5033-5042.
19. Krishnan V., Nestler E.J. The molecular neurobiology of depression. Nature 2008, 455(7215):894-902.
20. Lewicka M. Rational or uncommitted? Depression and indecisiveness in interpersonal decision making. Scand. J. Psychol. 1997, 38(3):227-236.
21. Liu X., et al. Proteomics reveal energy metabolism and mitogen-activated protein kinase signal transduction perturbation in human Borna disease virus Hu-H1-infected oligodendroglial cells. Neuroscience 2014, 268:284-296.
22. Lominac K.D., et al. Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function. J. Neurosci. 2005, 25(50):11586-11594.
23. Machado-Vieira R., et al. New therapeutic targets for mood disorders. ScientificWorldJournal 2010, 10:713-726.
24. Medina A., et al. Glutamate transporters: a key piece in the glutamate puzzle of major depressive disorder. J. Psychiatr. Res. 2013, 47(9):1150-1156.
25. Mi H., Muruganujan A., Thomas P.D. PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees. Nucleic Acids Res. 2013, 41(Database issue):D377-D386.
26. Middeldorp J., Hol E.M. GFAP in health and disease. Prog. Neurobiol. 2011, 93(3):421-443.
27. Miguel-Hidalgo J.J., et al. Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder. Biol. Psychiatry 2000, 48(8):861-873.
28. Moseley A.E., et al. Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice. J. Neurosci. 2007, 27(3):616-626.
29. Muller M.B., et al. Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus. Eur. J. Neurosci. 2001, 14(10):1603-1612.
30. Ongur, D., W.C. Drevets, and J.L. Price, Glial reduction in the subgenual prefrontal cortex in mood disorders.
31. Orsetti M., et al. Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression. Eur. J. Neurosci. 2008, 27(8):2156-2164.
32. Pelosi L., et al. Working memory dysfunction in major depression: an event-related potential study. Clin. Neuropsychol. 2000, 111(9):1531-1543.
33. Rajkowska, G. and J.J. Miguel-Hidalgo, Gliogenesis and glial pathology in depression.
34. Rezin G.T., et al. Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression. Neurochem. Int. 2008, 53(6-8):395-400.
35. Rietschel M., et al. Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression. Biol. Psychiatry 2010, 68(6):578-585.
36. Si X., et al. Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression. Neuropsychopharmacology 2004, 29(11):2088-2096.
37. Sofroniew M.V., Vinters H.V. Astrocytes: biology and pathology. Acta Neuropathol. 2010, 119(1):7-35.
38. Timmermans W., et al. Stress and excitatory synapses: from health to disease. Neuroscience 2013, 248:626-636.
39. Vizcaino J.A., et al. ProteomeXchange provides globally coordinated proteomics data submission and dissemination. Nat. Biotechnol. 2014, 32(3):223-226.
40. Vogel C., Marcotte E.M. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat. Rev. Genet. 2012, 13(4):227-232.
41. Wiborg O. Chronic mild stress for modeling anhedonia. Cell Tissue Res. 2013, 354(1):155-169.
42. Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology 1997, 134(4):319-329.
43. Willner P., Muscat R., Papp M. Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci. Biobehav. Rev. 1992, 16(4):525-534.
44. Zink M., et al. Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression. Neuropharmacology 2010, 58(2):465-473.