Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

Science

Volumn 352, Issue 6284, 2016, Pages

  Robison, Patrick ^a   Caporizzo, Matthew A ^b   Ahmadzadeh, Hossein ^b   Bogush, Alexey I ^a   Chen, Christina Yingxian ^a   Margulies, Kenneth B ^a   Shenoy, Vivek B ^b   Prosser, Benjamin L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; CARBOXYPEPTIDASE; DESMIN; PEPTIDE SYNTHASE; SMALL INTERFERING RNA; TUBULIN; TYROSINE; TYROSINE-TUBULIN; TYROSYLTUBULIN LIGASE;

CARDIOLOGY; CELLS AND CELL COMPONENTS; DISEASE INCIDENCE; PROTEIN; RODENT; SKELETON; SPATIAL RESOLUTION;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATOMIC FORCE MICROSCOPY; CARDIAC MUSCLE CELL; CELL FUNCTION; CELL PROLIFERATION; CHEMICAL REACTION; CONTROLLED STUDY; DETYROSINATION; HEART; HEART CONTRACTION; HEART MUSCLE CONTRACTILITY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; INTERMEDIATE FILAMENT; MECHANOTRANSDUCTION; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SARCOMERE; ANIMAL; BIOLOGICAL MODEL; ELASTICITY; GENETICS; HEART FAILURE; HUMAN; MALE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; SPRAGUE DAWLEY RAT;

ANIMALS; DESMIN; ELASTICITY; HEART FAILURE; HUMANS; MALE; MICE; MICROTUBULES; MODELS, BIOLOGICAL; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PEPTIDE SYNTHASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SARCOMERES; TUBULIN; TYROSINE;

EID: 84964792110     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf0659     Document Type: Article

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