Platelet dense granule secretion defects may obscure a-granule secretion mechanisms: Evidence from Munc13-4-deficient platelets

Blood

Volumn 125, Issue 19, 2015, Pages 3034-3036

  Harper, Matthew T ^a,b   Van Den Bosch, Marion T ^a   Hers, Ingeborg ^a   Poole, Alastair W ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CANGRELOR; MUNC13-4 PROTEIN; PADGEM PROTEIN; SEROTONIN; SNARE PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; P2RY12 PROTEIN, MOUSE; PURINERGIC P2Y12 RECEPTOR; THROMBOCYTE FACTOR 4; THROMBOXANE A2; UNC13D PROTEIN, MOUSE;

CELL GRANULE; CELLULAR SECRETION; INTRACELLULAR SIGNALING; LETTER; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE; ANIMAL; EXOCYTOSIS; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHYSIOLOGY; SECRETION (PROCESS); SECRETORY VESICLE; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ANIMALS; BLOOD PLATELETS; CYTOPLASMIC GRANULES; EXOCYTOSIS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PLATELET AGGREGATION; PLATELET FACTOR 4; RECEPTORS, PURINERGIC P2Y12; SECRETORY VESICLES; SIGNAL TRANSDUCTION; THROMBOXANE A2;

EID: 84964698105     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-12-618439     Document Type: Letter

References (5)

1. Meng R, Wu J, Harper DC, et al. Defective release of a granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood. 2015;125(10):1623-1632.
2. Sharda A, Kim SH, Jasuja R, et al. Defective PDI release from platelets and endothelial cells impairs thrombus formation in Hermansky-Pudlak syndrome. Blood. 2015;125(10):1633-1642.
3. Ren Q, Wimmer C, Chicka MC, et al. Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis. Blood. 2010;116(6):869-877.
4. Savage JS, Williams CM, Konopatskaya O, Hers I, Harper MT, Poole AW. Munc13-4 is critical for thrombosis through regulating release of ADP from platelets. J Thromb Haemost. 2013;11(4):771-775.
5. Stegner D, Deppermann C, Kraft P, et al. Munc13-4-mediated secretion is essential for infarct progression but not intracranial hemostasis in acute stroke. J Thromb Haemost. 2013;11(7):1430-1433.