Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice

Trends in Neurosciences

Volumn 39, Issue 6, 2016, Pages 353-355

  Pfau, Madeline L ^a   Russo, Scott J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation; Memory; Neurogenesis; Stress

Indexed keywords

MINOCYCLINE;

CELL PROLIFERATION; COGNITIVE DEFECT; DEPRESSION; DEPRESSIVE PSYCHOSIS; HIPPOCAMPUS; HUMAN; MEMORY DISORDER; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SHORT SURVEY; SOCIAL AVOIDANCE BEHAVIOR; SOCIAL INTERACTION; SPATIAL MEMORY; STRESS; ANIMAL; COGNITION; MEMORY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; COGNITION; COGNITION DISORDERS; COGNITIVE DYSFUNCTION; HIPPOCAMPUS; HUMANS; MEMORY; NEUROGENESIS;

EID: 84964632161     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2016.04.004     Document Type: Short Survey

References (13)

1. Gualtieri C.T., Morgan D.W. The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: an unaccounted source of variance in clinical trials. J. Clin. Psychiatry 2008, 69:1122-1130.
2. Papakostas G.I., Culpepper L. Understanding and managing Cognition in the Depressed Patient. J. Clin. Psychiatry 2015, 76:418-425.
3. McKim D.B., et al. Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat. J. Neurosci. 2016, 36:2590-2604.
4. Golden S.A., et al. A standardized protocol for repeated social defeat stress in mice. Nature protocols 2011, 6:1183-1191.
5. Krishnan V., et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 2007, 131:391-404.
6. Hodes G.E., et al. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:16136-16141.
7. Wohleb E.S., et al. beta-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J. Neurosci. 2011, 31:6277-6288.
8. Wohleb E.S., et al. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J. Neurosci. 2013, 33:13820-13833.
9. Powell N.D., et al. Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via beta-adrenergic induction of myelopoiesis. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:16574-16579.
10. Garrido-Mesa N., et al. Minocycline: far beyond an antibiotic. Br. J. Pharmacol. 2013, 169:337-352.
11. Miyaoka T., et al. Minocycline as adjunctive therapy for patients with unipolar psychotic depression: an open-label study. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 37:222-226.
12. Mayer E.A., et al. Gut microbes and the brain: paradigm shift in neuroscience. J. Neurosci. 2014, 34:15490-15496.
13. Lagace D.C., et al. Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:4436-4441.