Wound complications and surgical events in de novo heart transplant patients treated with everolimus: Post-hoc analysis of the SCHEDULE trial

International Journal of Cardiology

Volumn 210, Issue , 2016, Pages 80-84

  Rashidi, Mitra ^a   Esmaily, Sorosh ^b   Fiane, Arnt E ^a,c   Gude, Einar ^a   Atønseth, Kim ^a,c   Ueland, Thor ^c,d,e,f   Gustafsson, Finn ^g   Eiskjær, Hans ^h   Rådegran, Göran ⁱ   Dellgren, Göran ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF OSLO   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF OSLO   (Norway)

^f UNIVERSITY OF TROMSØ   (Norway)

^g Rigshospitalet   (Denmark)

^h AARHUS UNIVERSITY HOSPITAL   (Denmark)

ⁱ LUND UNIVERSITY   (Sweden)

Author keywords

Heart transplantation; Randomized study; Surgical events; Wound infection

Indexed keywords

CYCLOSPORIN A; EVEROLIMUS; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ADULT; ARTICLE; BONE DISEASE; CONTROLLED STUDY; DRUG DOSE REDUCTION; FEMALE; FISTULA; GASTROINTESTINAL SYMPTOM; HEART TRANSPLANTATION; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; POST HOC ANALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; RISK FACTOR; SURGICAL INFECTION; WOUND COMPLICATION; WOUND DEHISCENCE; ADVERSE EFFECTS; CLINICAL TRIAL; FOLLOW UP; GRAFT REJECTION; MIDDLE AGED; MULTICENTER STUDY; SURGICAL WOUND INFECTION; TREATMENT OUTCOME; TRENDS;

ADULT; CYCLOSPORINE; EVEROLIMUS; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; RISK FACTORS; SURGICAL WOUND INFECTION; TREATMENT OUTCOME;

EID: 84964579558     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2016.02.075     Document Type: Article

References (14)

1. Zuckermann A., and Barten M.J. Surgical wound complications after heart transplantation Transpl Int 24 2011 627 636
2. Nashan B., and Citterio F. Wound healing complications and the use of mammalian target of rapamycin inhibitors in kidney transplantation: A critical review of the literature Transplantation 94 2012 547 561
3. Carrier M., Perrault LP, Pellerin M., Marchand R., Auger P., Pelletier GB, and et al. Sternal wound infection after heart transplantation: incidence and results with aggressive surgical treatment Ann Thorac Surg 72 2001 719 723
4. Filsoufi F., Rahmanian P.B., Castillo J.G., Pinney S., Broumand S.R., and Adams D.H. Incidence, treatment strategies and outcome of deep sternal wound infection after orthotopic heart transplantation. Incidence, treatment strategies and outcome of deep sternal wound infection after orthotopic heart transplantation J Heart Lung Transplant 26 2007 1084 1090
5. Eisen H.J., Kobashigawa J., Starling R.C., Pauly D.F., Kfoury A., Ross H., and et al. Everolimus versus mycophenolate mofetil in heart transplantation: a randomized, multicenter trial.everolimus versus mycophenolate mofetil in heart transplantation: a randomized, multicenter trial Am J Transplant 13 2013 1203 1216
6. Andreassen A.K., Andersson B., Gustafsson F., Eiskjaer H., Radegran G., Gude E., and et al. SCHEDULE Investigators. Everolimus initiation and early calcineurin inhibitor withdrawal in heart transplant recipients: a randomized trial. Everolimus initiation and early calcineurin inhibitor withdrawal in heart transplant recipients: a randomized trial Am J Transplant 14 2014 1828 1838
7. Gullestad L., Iversen MIversen M., Mortensen SA, Eiskjaer H., Riise GC, Mared L., and et al. Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: a multicenter, randomized trial Transplantation 89 2010 864 872
8. Zuckermann A., Wang S.S., Epailly E., Barten M.J., Sigurdardottir V., Segovia J., and et al. Efficacy and safety of low-dose cyclosporine with everolimus and steroids in de novo heart transplant patients: a multicenter, randomized trial. J. Transplant. 2011 1 7
9. Loop FD, Lytle BW, Cosgrove DM, Mahfood S., McHenry MC, Goormastic M., and et al. Sternal wound complications after isolated coronary artery bypass grafting: early and late mortality, morbidity and cost of care Ann Thorac Surg 49 1990 179 187
10. De Feo M., Renzulli A., Ismeno G., Gregorio R., Della Corte A., Utili R., and et al. Variables predicting adverse outcome in patients with deep sternal wound infection Ann Thorac Surg 71 2001 324 331
11. Francel T.J., and Kouchoukos N.T. A rational approach to wound difficulties after sternotomy: reconstruction and long-term results Ann Thorac Surg 72 2001 1419 1429
12. Thurer RJ, Bognolo D., Vargas A., Isch JH, and Kaiser GA The management of mediastinal infection following cardiac surgery: an experience utilizing continuous irrigation with povidone-iodine J Thorac Cardiovasc Surg 68 1974 962 968
13. Gummert JF, Barten MJ, Hans C., Kluge M., Doll N., Walther T., and et al. Mediastinitis and cardiac surgery - an updated risk factor analysis in 10,373 consecutive adult patients J Thorac Cardiovasc Surg 50 2002 87 91
14. Rashidi M., Barstad M., Brunborg C., and Fiane A. Bilateral pectoralis muscle advancement flap in the management of deep sternal wound infection: a single clinic study of clinical outcome and postoperative quality of life Eur J Plast Surg 37 2014 423 430