Eucaloric Ketogenic Diet Reduces Hypoglycemia and Inflammation in Mice with Endotoxemia

Lipids

Volumn 51, Issue 6, 2016, Pages 703-714

  Nandivada, Prathima ^a   Fell, Gillian L ^a   Pan, Amy H ^a   Nose, Vania ^b   Ling, Pei Ra ^c   Bistrian, Bruce R ^c   Puder, Mark ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Endotoxin; Hypoglycemia; Inflammation; Ketogenic diet

Indexed keywords

ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 6; KETONE; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DIET THERAPY; ENDOTOXEMIA; EUCALORIC KETOGENIC DIET; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; GLYCOGEN ANALYSIS; GLYCOGEN LIVER LEVEL; HYPOGLYCEMIA; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; KETOGENIC DIET; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; POSTPRANDIAL STATE; PROTEIN EXPRESSION; ANIMAL; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; TREATMENT OUTCOME;

ANIMALS; ENDOTOXEMIA; GENE EXPRESSION REGULATION; HYPOGLYCEMIA; INSULIN RESISTANCE; INTERLEUKIN-6; KETOGENIC DIET; LIPOPOLYSACCHARIDES; MALE; MICE; POSTPRANDIAL PERIOD; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84964495154     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-016-4156-7     Document Type: Article

References (28)

1. Bagshaw SM, Bellomo R, Jacka MJ, Egi M, Hart GK, George C (2009) The impact of early hypoglycemia and blood glucose variability on outcome in critical illness. Crit Care 13:R91
2. Kreymann KG, Berger MM, Deutz NEP, Hiesmayr M, Jolliet P, Kazandjiev G, Nitenberg G, van den Berghe G, Wernerman J, Ebner C, Hartl W, Heymann C, Spies C (2006) ESPEN guidelines on enteral nutrition: intensive care. Clin Nutr 25(2):210–223
3. Gosmanov AR, Umpierrez GE (2013) Management of hyperglycemia during enteral and parenteral nutrition therapy. Curr Diab 13(1):155–162
4. Egi M, Bellomo R, Stachowski E, French CJ, Hart GK, Taori G, Hegarty C, Bailey M (2010) Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc 85(3):217–224
5. Phinney SD, Bistrian BR, Wolfe RR, Blackburn GL (1983) The human metabolic response to chronic ketosis without caloric restriction: physical and biochemical adaptation. Metabolism 32(8):757–768
6. Badman MK, Kennedy AR, Adams AC, Pissios P, Maratos-Flier E (2009) A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss. Am J Physiol Endocrinol Metab 297(5):E1197–E1204
7. Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E (2013) Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339(6116):211–214
8. Ruskin DN, Kawamura M, Masino SA (2009) Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. PLoS One 4(12):e8349
9. Kim DY, Davis LM, Sullivan PG, Maalouf M, Simeone TA, van Brederode J, Rho JM (2007) Ketone bodies are protective against oxidative stress in neocortical neurons. J Neurochem 101(5):1316–1326
10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–419
11. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu Y-C, Torbenson MS, Unalp-Arida A, Yeh M, McCullough AJ, Sanyal AJ (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41(6):1313–1321
12. Ling P-R, Smith RJ, Bistrian BR (2005) Hyperglycemia enhances the cytokine production and oxidative responses to a low but not high dose of endotoxin in rats. Crit Care Med 33(5):1084–1089
13. Filkins J, Cornell R (1974) Depression of hepatic gluconeogenesis and the hypoglycemia of endotoxin shock. Am J Physiol 227(4):778–781
14. Ling PR, Bistrian BR, Mendez B, Istfan NW (1994) Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism 43(3):279–284
15. Westman EC, Mavropoulos J, Yancy WS, Volek JS (2003) A review of low-carbohydrate ketogenic diets. Curr Atheroscler Rep 5(6):476–483
16. Westman EC, Feinman RD, Mavropoulos JC, Vernon MC, Volek JS, Wortman JA, Yancy WS, Phinney SD (2007) Low-carbohydrate nutrition and metabolism. Am J Clin Nutr 86(2):276–284
17. Randle PJ, Garland PB, Hales CN, Newsholme EA (1963) The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1(7285):785–789
18. Shulman GI (2014) Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371(23):2236–2238
19. Samuel VT, Liu Z-X, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI (2004) Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279(31):32345–32353
20. Garbow JR, Doherty JM, Schugar RC, Travers S, Weber ML, Wentz AE, Ezenwajiaku N, Cotter DG, Brunt EM, Crawford PA (2011) Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. Am J Physiol Gastrointest Liver Physiol 300(6):G956–G967
21. Volek JS, Sharman MJ, Love DM, Avery NG, Gómez AL, Scheett TP, Kraemer WJ (2002) Body composition and hormonal responses to a carbohydrate-restricted diet. Metabolism 51(7):864–870
22. Kennedy AR, Pissios P, Otu H, Roberson R, Xue B, Asakura K, Furukawa N, Marino FE, Liu F-F, Kahn BB, Libermann TA, Maratos-Flier E (2007) A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab 292(6):E1724–E1739
23. Jornayvaz FR, Jurczak MJ, Lee H-Y, Birkenfeld AL, Frederick DW, Zhang D, Zhang X-M, Samuel VT, Shulman GI (2010) A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. Am J Physiol Endocrinol Metab 299(5):E808–E815
24. Pissios P, Hong S, Kennedy AR, Prasad D, Liu F-F, Maratos-Flier E (2013) Methionine and choline regulate the metabolic phenotype of a ketogenic diet. Mol Metab 2(3):306–313
25. Youm Y-H, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D’Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD (2015) The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med 21(3):263–269
26. Ziegler DR, Ribeiro LC, Hagenn M, Siqueira IR, Araújo E, Torres ILS, Gottfried C, Netto CA, Gonçalves C-A (2003) Ketogenic diet increases glutathione peroxidase activity in rat hippocampus. Neurochem Res 28(12):1793–1797
27. Sullivan PG, Rippy NA, Dorenbos K, Concepcion RC, Agarwal AK, Rho JM (2004) The ketogenic diet increases mitochondrial uncoupling protein levels and activity. Ann Neurol 55(4):576–580
28. Veech RL (2004) The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids 70(3):309–319