Sensitivity Analysis of a Pharmacokinetic Model of Vaginal Anti-HIV Microbicide Drug Delivery

Journal of Pharmaceutical Sciences

Volumn 105, Issue 5, 2016, Pages 1772-1778

  Jarrett, Angela M ^a   Gao, Yajing ^b   Hussaini, M Yousuff ^a   Cogan, Nicholas G ^a   Katz, David F ^b  

^a FLORIDA STATE UNIVERSITY   (United States)

^b Duke University   (United States)

Author keywords

biophysical models; computational biology; drug design; dynamic simulation; HIV AIDS; in silico modeling; mathematical model; Monte Carlo; mucosal delivery; pharmacokinetics

Indexed keywords

MICROBICIDE; TENOFOVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIVIRUS AGENT; TOPICAL ANTIINFECTIVE AGENT;

ARTICLE; COMPARTMENT MODEL; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; MATHEMATICAL MODEL; PARTITION COEFFICIENT; SENSITIVITY ANALYSIS; STROMA CELL; VAGINA EPITHELIUM; VAGINA MUCOSA; BIOLOGICAL MODEL; COMPUTER SIMULATION; DRUG EFFECTS; FEMALE; HUMAN; METABOLISM; PROCEDURES; VAGINA; VIROLOGY;

ANTI-HIV AGENTS; ANTI-INFECTIVE AGENTS, LOCAL; ANTIVIRAL AGENTS; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; MODELS, BIOLOGICAL; TENOFOVIR; VAGINA;

EID: 84964489877     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/j.xphs.2016.02.015     Document Type: Article

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