Frequent detection of HCV RNA and HCVcoreAg in stool of patients with chronic hepatitis C

Journal of Clinical Virology

Volumn 80, Issue , 2016, Pages 1-7

  Heidrich, Benjamin ^a,b   Steinmann, Eike ^c   Plumeier, Iris ^b   Kirschner, Janina ^a   Sollik, Lisa ^a   Ziegert, Szilvia ^a   Engelmann, Michael ^c   Lehmann, Patrick ^a   Manns, Michael Peter ^a,b   Pieper, Dietmar Helmut ^b   Wedemeyer, Heiner ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

Author keywords

HCV; HCV RNA; HCVcoreAg; Hepatitis C; Transmission

Indexed keywords

HEPATITIS C ANTIGEN; HEPATITIS C CORE ANTIGEN; UNCLASSIFIED DRUG; VIRUS RNA;

ADULT; ARTICLE; BILE; CHRONIC HEPATITIS C; FECES; FECES ANALYSIS; FEMALE; HEPATITIS C VIRUS SUBTYPE 2A; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OCCULT BLOOD; OCCULT BLOOD TEST; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; THROMBOCYTE COUNT; VIRUS PARTICLE; AGED; GENETICS; HEPACIVIRUS; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; SEX DIFFERENCE; SEXUAL BEHAVIOR; TRANSMISSION; VERY ELDERLY; VIROLOGY;

ADULT; AGED; AGED, 80 AND OVER; FECES; FEMALE; HEPACIVIRUS; HEPATITIS C ANTIGENS; HEPATITIS C, CHRONIC; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT; PROSPECTIVE STUDIES; RNA, VIRAL; SEX FACTORS; SEXUAL BEHAVIOR;

EID: 84964452787     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2016.04.006     Document Type: Article

References (24)

1. Gower E., Estes C., Blach S., Razavi-Shearer K., Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J. Hepatol. 2014, 10.1016/j.jhep.2014.07.027.
2. Webster D.P., Klenerman P., Dusheiko G.M., Hepatitis C. Lancet 2015, 385:1124-1135. 10.1016/S0140-6736(14)62401-6.
3. Wedemeyer H. Towards interferon-free treatment for all HCV genotypes. Lancet 2015, 10.1016/s0140-6736(15)60605-5.
4. Wedemeyer H., Duberg A.S., Buti M., Rosenberg W.M., Frankova S., Esmat G., et al. Strategies to manage hepatitis C virus (HCV) disease burden. J. Viral Hepat. 2014, 21(Suppl 1):60-89. 10.1111/jvh.12249.
5. de R.A., Pondé A. Hidden hazards of HCV transmission. Med. Microbiol. Immunol. (Berl.). 2011, 200:7-11. 10.1007/s00430-010-0159-9.
6. Klevens R.M., Hu D.J., Jiles R., Holmberg S.D. Evolving epidemiology of hepatitis C virus in the United States. Clin. Infect. Dis. 2012, 55(Suppl. 1):S3-9. 10.1093/cid/cis393.
7. Zou S., Dorsey K.A., Notari E.P., Foster G.A., Krysztof D.E., Musavi F., et al. Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing. Transfusion (Paris) 2010, 50:1495-1504. 10.1111/j.1537-2995.2010.02622. x.
8. Cornberg M., Razavi H.A., Alberti A., Bernasconi E., Buti M., Cooper C., et al. A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel. Liver Int. 2011, 31(Suppl. 2):30-60. 10.1111/j.1478-3231.2011.02539.x.
9. Danta M., Rodger A.J. Transmission of HCV in HIV-positive populations. Curr. Opin. HIV AIDS 2011, 6:451-458. 10.1097/COH.0b013e32834b4974.
10. Danta M., Brown D., Bhagani S., Pybus O.G., Sabin C.A., Nelson M., et al. Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS Lond. Engl. 2007, 21:983-991. 10.1097/QAD.0b013e3281053a0c.
11. Kumar R.M., Shahul S. Role of breast-feeding in transmission of hepatitis C virus to infants of HCV-infected mothers. J. Hepatol. 1998, 29:191-197.
12. Suzuki T., Omata K., Satoh T., Miyasaka T., Arai C., Maeda M., et al. Quantitative detection of hepatitis C virus (HCV) RNA in saliva and gingival crevicular fluid of HCV-infected patients. J. Clin. Microbiol. 2005, 43:4413-4417. 10.1128/JCM.43.9.4413-4417.2005.
13. Haruna Y., Kanda T., Honda M., Takao T., Hayashi N. Detection of hepatitis C virus in the bile and bile duct epithelial cells of hepatitis C virus-infected patients. Hepatol. Baltim. Md. 2001, 33:977-980. 10.1053/jhep.2001.23435.
14. Beyrer C., Sullivan P., Sanchez J., Baral S.D., Collins C., Wirtz A.L., et al. The increase in global HIV epidemics in MSM. AIDS Lond. Engl. 2013, 27:2665-2678. 10.1097/01.aids.0000432449.30239.fe.
15. Baggaley R.F., Dimitrov D., Owen B.N., Pickles M., Butler A.R., Masse B., et al. Heterosexual anal intercourse: a neglected risk factor for HIV?. Am. J. Reprod. Immunol. N. Y. N 1989 2013, 69(Suppl. 1):95-105. 10.1111/aji.12064.
16. Heidrich B., Pischke S., Helfritz F.A., Mederacke I., Kirschner J., Schneider J., et al. Hepatitis C virus core antigen testing in liver and kidney transplant recipients. J. Viral Hepat. 2014, 21:769-779. 10.1111/jvh.12204.
17. Hammes P.H., Gnauck R., Hawle H. Screening for colorectal neoplasms: comparison of Hemdetect and Haemoccult. Z. Für Gastroenterol. 1989, 27:611-613.
18. Pietschmann T., Kaul A., Koutsoudakis G., Shavinskaya A., Kallis S., Steinmann E., et al. Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:7408-7413. 10.1073/pnas.0504877103.
19. Ciesek S., von Hahn T., Colpitts C.C., Schang L.M., Friesland M., Steinmann J., et al. The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry. Hepatol. Baltim. Md. 2011, 54:1947-1955. 10.1002/hep.24610.
20. Wakita T., Pietschmann T., Kato T., Date T., Miyamoto M., Zhao Z., et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 2005, 11:791-796. 10.1038/nm1268.
21. Wang C.C., Morishima C., Chung M., Engelberg R., Krantz E., Krows M., et al. High serum hepatitis C virus (HCV) RNA load predicts the presence of HCV RNA in saliva from individuals with chronic and acute HCV infection. J. Infect. Dis. 2006, 193:672-676. 10.1086/499602.
22. Yanaga K., Yoshizumi T., Uchiyama H., Okano S., Takenaka K., Sugimachi K. Detection of hepatitis C virus RNA in bile. Am. J. Gastroenterol. 1997, 92:1927-1928.
23. Lindenbach B.D. Virion assembly and release. Curr. Top. Microbiol. Immunol. 2013, 369:199-218. 10.1007/978-3-642-27340-7_8.
24. Smith G.I., Reeds D.N., Okunade A.L., Patterson B.W., Mittendorfer B. Systemic delivery of estradiol, but not testosterone or progesterone, alters very low density lipoprotein-triglyceride kinetics in postmenopausal women. J. Clin. Endocrinol. Metab. 2014, 99:E1306-1310. 10.1210/jc.2013-4470.