Reducing Microvascular Dysfunction in Revascularized Patients with ST-Elevation Myocardial Infarction by Off-Target Properties of Ticagrelor versus Prasugrel. Rationale and Design of the REDUCE-MVI Study

Journal of Cardiovascular Translational Research

Volumn 9, Issue 3, 2016, Pages 249-256

  Janssens, Gladys N ^a   van Leeuwen, Maarten A H ^a   van der Hoeven, Nina W ^a   de Waard, Guus A ^a   Nijveldt, Robin ^a   Diletti, Roberto ^b   Zijlstra, Felix ^b   von Birgelen, Clemens ^c   Escaned, Javier ^d   Valgimigli, Marco ^e   van Royen, Niels ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF TWENTE   (Netherlands)

^d HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^e BERN UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Adenosine; Microvascular injury; Prasugrel; ST elevation myocardial infarction; Ticagrelor

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE; GADOLINIUM; GLYCERYL TRINITRATE; HEPARIN; PRASUGREL; TICAGRELOR; ANTITHROMBOCYTIC AGENT; PURINERGIC P2Y RECEPTOR ANTAGONIST;

ANTICOAGULANT THERAPY; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORONARY ANGIOGRAPHY; CORONARY ARTERY OBSTRUCTION; DRUG SAFETY; ENDOTHELIAL DYSFUNCTION; GUIDE WIRE; HUMAN; LOADING DRUG DOSE; MAINTENANCE DRUG DOSE; MAJOR CLINICAL STUDY; MICROANGIOPATHY; MULTICENTER STUDY; OPEN STUDY; OPTICAL COHERENCE TOMOGRAPHY; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REVASCULARIZATION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TREATMENT OUTCOME; TREATMENT RESPONSE; VASCULAR RESISTANCE; ANALOGS AND DERIVATIVES; CLINICAL PROTOCOL; COMPARATIVE STUDY; DRUG EFFECTS; FRACTIONAL FLOW RESERVE; HEART CATHETERIZATION; METHODOLOGY; MICROCIRCULATION; MYOCARDIAL REPERFUSION INJURY; NETHERLANDS; PATHOPHYSIOLOGY; SPAIN; ST ELEVATION MYOCARDIAL INFARCTION; TIME FACTOR;

ADENOSINE; CARDIAC CATHETERIZATION; CLINICAL PROTOCOLS; FRACTIONAL FLOW RESERVE, MYOCARDIAL; HUMANS; MICROCIRCULATION; MYOCARDIAL REPERFUSION INJURY; NETHERLANDS; PERCUTANEOUS CORONARY INTERVENTION; PLATELET AGGREGATION INHIBITORS; PRASUGREL HYDROCHLORIDE; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RESEARCH DESIGN; SPAIN; ST ELEVATION MYOCARDIAL INFARCTION; TIME FACTORS; TOMOGRAPHY, OPTICAL COHERENCE; TREATMENT OUTCOME; VASCULAR RESISTANCE;

EID: 84964336819     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-016-9691-3     Document Type: Article

References (32)

1. Zijlstra, F., Hoorntje, J. C., de Boer, M. J., Reiffers, S., Miedema, K., Ottervanger, J. P., van ’t Hof, A. W., & Suryapranata, H. (1999). Long-term benefit of primary angioplasty as compared with thrombolytic therapy for acute myocardial infarction. New England Journal of Medicine, 341, 1413–9.
2. Teunissen, P. F., de Waard, G. A., Hollander, M. R., Robbers, L. F., Danad, I., Biesbroek, P. S., Amier, R. P., Echavarria-Pinto, M., Quiros, A., Broyd, C., Heymans, M. W., Nijveldt, R., Lammertsma, A. A., Raijmakers, P. G., Allaart, C. P., Lemkes, J. S., Appelman, Y. E., Marques, K. M., Bronzwaer, J. G., Horrevoets, A. J., Van Rossum, A. C., Escaned, J., Beek, A. M., Knaapen, P., & van Roven, N. (2015). Doppler-derived intracoronary physiology indices predict the occurrence of microvascular injury and microvascular perfusion deficits after angiographically successful primary percutaneous coronary intervention. Circulation. Cardiovascular Interventions, 8, e001786.
3. Ng, M. K., Yeung, A. C., & Fearon, W. F. (2006). Invasive assessment of the coronary microcirculation: superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve. Circulation, 113, 2054–61.
4. Wu, K. C., Zerhouni, E. A., Judd, R. M., Lugo-Olivieri, C. H., Barouch, L. A., Schulman, S. P., Blumenthal, R. S., & Lima, J. A. (1998). Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation, 97, 765–72.
5. Nijveldt, R., Beek, A. M., Hirsch, A., Stoel, M. G., Hofman, M. B., Umans, V. A., Algra, P. R., Twisk, J. W., & Van Rossum, A. C. (2008). Functional recovery after acute myocardial infarction: comparison between angiography, electrocardiography, and cardiovascular magnetic resonance measures of microvascular injury. Journal of the American College of Cardiology, 52, 181–9.
6. Reffelmann, T., & Kloner, R. A. (2004). Microvascular alterations after temporary coronary artery occlusion: the no-reflow phenomenon. Journal of Cardiovascular Pharmacology and Therapeutics, 9, 163–72.
7. Jaffe, R., Charron, T., Puley, G., Dick, A., & Strauss, B. H. (2008). Microvascular obstruction and the no-reflow phenomenon after percutaneous coronary intervention. Circulation, 117, 3152–6.
8. Barletta, K. E., Ley, K., & Mehrad, B. (2012). Regulation of neutrophil function by adenosine. Arteriosclerosis, Thrombosis, and Vascular Biology, 32, 856–64.
9. Csoka, B., Nemeth, Z. H., Rosenberger, P., Eltzschig, H. K., Spolarics, Z., Pacher, P., Selmeczy, Z., Koscso, B., Himer, L., Vizi, E. S., Blackburn, M. R., Deitch, E. A., & Hasko, G. (2010). A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation. Journal of Immunology, 185, 542–50.
10. Steg, P. G., James, S. K., & Gersh, B. J. (2013). 2012 ESC STEMI guidelines and reperfusion therapy: evidence-based recommendations, ensuring optimal patient management. Heart, 99, 1156–7.
11. O’Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Jr., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C., Fesmire, F. M., Franklin, B. A., Granger, C. B., Krumholz, H. M., Linderbaum, J. A., Morrow, D. A., Newby, L. K., Ornato, J. P., Ou, N., Radford, M. J., Tamis-Holland, J. E., Tommaso, C. L., Tracy, C. M., Woo, Y. J., Zhao, D. X., Anderson, J. L., Jacobs, A. K., et al. (2013). 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology, 61, e78–140.
12. Alexopoulos, D., Xanthopoulou, I., Gkizas, V., Kassimis, G., Theodoropoulos, K. C., Makris, G., Koutsogiannis, N., Damelou, A., Tsigkas, G., Davlouros, P., & Hahalis, G. (2012). Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with ST-segment-elevation myocardial infarction. Circulation. Cardiovascular Interventions, 5, 797–804.
13. Schulz, S., Angiolillo, D. J., Antoniucci, D., Bernlochner, I., Hamm, C., Jaitner, J., Laugwitz, K. L., Mayer, K., von Merzljak, B., Morath, T., Neumann, F. J., Richardt, G., Ruf, J., Schomig, G., Schuhlen, H., Schunkert, H., & Kastrati, A. (2014). Randomized comparison of ticagrelor versus prasugrel in patients with acute coronary syndrome and planned invasive strategy--design and rationale of the iNtracoronary stenting and antithrombotic regimen: rapid early action for coronary treatment (ISAR-REACT) 5 trial. Journal of Cardiovascular Translational Research, 7, 91–100.
14. van Giezen, J. J., Sidaway, J., Glaves, P., Kirk, I., & Bjorkman, J. A. (2012). Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine model. Journal of Cardiovascular Pharmacology and Therapeutics, 17, 164–72.
15. Armstrong, D., Summers, C., Ewart, L., Nylander, S., Sidaway, J. E., & van Giezen, J. J. (2014). Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1. Journal of Cardiovascular Pharmacology and Therapeutics, 19, 209–19.
16. Bonello, L., Laine, M., Kipson, N., Mancini, J., Helal, O., Fromonot, J., Gariboldi, V., Condo, J., Thuny, F., Frere, C., Camoin-Jau, L., Paganelli, F., Dignat-George, F., & Guieu, R. (2014). Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome. Journal of the American College of Cardiology, 63, 872–7.
17. Cattaneo, M., Schulz, R., & Nylander, S. (2014). Adenosine-mediated effects of ticagrelor: evidence and potential clinical relevance. Journal of the American College of Cardiology, 63, 2503–9.
18. Van’t Hof, A. W., Liem, A., Suryapranata, H., Hoorntje, J. C., de Boer, M. J., & Zijlstra, F. (1998). Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction: myocardial blush grade. Zwolle myocardial infarction study group. Circulation, 97, 2302–6.
19. Windecker, S., Kolh, P., Alfonso, F., Collet, J. P., Cremer, J., Falk, V., Filippatos, G., Hamm, C., Head, S. J., Juni, P., Kappetein, A. P., Kastrati, A., Knuuti, J., Landmesser, U., Laufer, G., Neumann, F. J., Richter, D. J., Schauerte, P., Sousa, U. M., Stefanini, G. G., Taggart, D. P., Torracca, L., Valgimigli, M., Wijns, W., & Witkowski, A. (2014). 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). European Heart Journal, 35, 2541–619.
20. Hamburg, N. M., & Benjamin, E. J. (2009). Assessment of endothelial function using digital pulse amplitude tonometry. Trends in Cardiovascular Medicine, 19, 6–11.
21. Kandhai-Ragunath, J. J., Jorstad, H. T., de Man, F. H., Peters, R. J., & von Birgelen, C. (2013). Approaches for non-invasive assessment of endothelial function: focus on peripheral arterial tonometry. Netherlands Heart Journal, 21, 214–8.
22. Kandhai-Ragunath, J. J., Jorstad, H. T., de Wagenaar, B., de Man, F. H., Stoel, M. G., van Es, J., Doelman, C. J., Doggen, C. J., Peters, R. J., & von Birgelen, C. (2014). Assessment of the relation between initial culprit vessel patency in acute ST-elevation myocardial infarction and endothelial function. EuroIntervention, 10, 784–91.
23. Suessenbacher, A., Dorler, J., Wanitschek, M., Alber, F., Pachinger, O., & Frick, M. (2014). Prognostic value of peripheral arterial tonometry in patients with coronary artery disease and a high cardiovascular risk profile. Journal of Atherosclerosis and Thrombosis, 21, 230–8.
24. Kikkert, W. J., van Geloven, N., van der Laan, M. H., Vis, M. M., Baan, J., Jr., Koch, K. T., Peters, R. J., de Winter, R. J., Piek, J. J., Tijssen, J. G., & Henriques, J. P. (2014). The prognostic value of bleeding academic research consortium (BARC)-defined bleeding complications in ST-segment elevation myocardial infarction: a comparison with the TIMI (Thrombolysis in Myocardial Infarction), GUSTO (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries), and ISTH (International Society on Thrombosis and Haemostasis) bleeding classifications. Journal of the American College of Cardiology, 63, 1866–75.
25. The GUSTO investigators. (1993). An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. New England Journal of Medicine, 329, 673–82.
26. Hirohata, A., Yamamoto, K., Hirose, E., Kobayashi, Y., Takafuji, H., Sano, F., Matsumoto, K., Ohara, M., Yoshioka, R., Takinami, H., & Ohe, T. (2014). Nicorandil prevents microvascular dysfunction resulting from PCI in patients with stable angina pectoris: a randomised study. EuroIntervention, 9, 1050–6.
27. Frohlich, G. M., Meier, P., White, S. K., Yellon, D. M., & Hausenloy, D. J. (2013). Myocardial reperfusion injury: looking beyond primary PCI. European Heart Journal, 34, 1714–22.
28. Wallentin, L., Becker, R. C., Budaj, A., Cannon, C. P., Emanuelsson, H., Held, C., Horrow, J., Husted, S., James, S., Katus, H., Mahaffey, K. W., Scirica, B. M., Skene, A., Steg, P. G., Storey, R. F., Harrington, R. A., Freij, A., & Thorsen, M. (2009). Ticagrelor versus clopidogrel in patients with acute coronary syndromes. New England Journal of Medicine, 361, 1045–57.
29. Wiviott, S. D., Braunwald, E., McCabe, C. H., Montalescot, G., Ruzyllo, W., Gottlieb, S., Neumann, F. J., Ardissino, D., De, S. S., Murphy, S. A., Riesmeyer, J., Weerakkody, G., Gibson, C. M., & Antman, E. M. (2007). Prasugrel versus clopidogrel in patients with acute coronary syndromes. New England Journal of Medicine, 357, 2001–15.
30. Ziegler-Heitbrock, L., Ancuta, P., Crowe, S., Dalod, M., Grau, V., Hart, D. N., Leenen, P. J., Liu, Y. J., MacPherson, G., Randolph, G. J., Scherberich, J., Schmitz, J., Shortman, K., Sozzani, S., Strobl, H., Zembala, M., Austyn, J. M., & Lutz, M. B. (2010). Nomenclature of monocytes and dendritic cells in blood. Blood, 116, e74–e80.
31. Fernandez, P., Jara, C., Aguilera, V., Caviedes, L., Diaz, F., Radojkovic, C., Veas, C., Lamperti, L., Escudero, C., & Aguayo, C. (2012). Adenosine A(2)A and A(3) receptors are involved in the human endothelial progenitor cells migration. Journal of Cardiovascular Pharmacology, 59, 397–404.
32. Layland, J., Carrick, D., McEntegart, M., Ahmed, N., Payne, A., McClure, J., Sood, A., McGeoch, R., MacIsaac, A., Whitbourn, R., Wilson, A., Oldroyd, K., & Berry, C. (2013). Vasodilatory capacity of the coronary microcirculation is preserved in selected patients with non-ST-segment-elevation myocardial infarction. Circulation. Cardiovascular Interventions, 6, 231–6.