Effects of the inverse alpha-agonist doxazosin in allergic rhinitis

Clinical and Experimental Allergy

Volumn 46, Issue 5, 2016, Pages 696-704

  Manoharan, A ^a   Morrison, A E ^a   Lipworth, B J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Allergic rhinitis; Alpha receptor antagonist; Alpha receptor inverse agonist; Doxazosin; Peak nasal inspiratory flow

Indexed keywords

DOXAZOSIN; OXYMETAZOLINE; PLACEBO; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BIOLOGICAL MARKER;

ADULT; ALLERGIC RHINITIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG RELEASE; DRUG RESPONSE; FEMALE; HEART RATE; HUMAN; MALE; NOSE AIRFLOW; PEAK NASAL INSPIRATORY FLOW; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; TREATMENT OUTCOME; VISUAL ANALOG SCALE; CLINICAL TRIAL; IMMUNOLOGY; METABOLISM; NOSE PROVOCATION TEST; SKIN TEST;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; BIOMARKERS; DOXAZOSIN; FEMALE; HUMANS; MALE; NASAL PROVOCATION TESTS; RHINITIS, ALLERGIC; SKIN TESTS; TREATMENT OUTCOME;

EID: 84964335027     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12700     Document Type: Article

References (26)

1. Bousquet J, Schunemann HJ, Samolinski B et al. Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol 2012; 130:1049-62.
2. Graf P. Long-term use of oxy- and xylometazoline nasal sprays induces rebound swelling, tolerance, and nasal hyperreactivity. Rhinology 1996; 34:9-13.
3. Graf P. Rhinitis medicamentosa: aspects of pathophysiology and treatment. Allergy 1997; 52:28-34.
4. Vaidyanathan S, Williamson P, Clearie K, Khan F, Lipworth B. Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion. Am J Respir Crit Care Med 2010; 182:19-24.
5. Corboz MR, Rivelli MA, Varty L et al. Pharmacological characterization of postjunctional alpha-adrenoceptors in human nasal mucosa. Am J Rhinol 2005; 19:495-502.
6. Vincent J, Dachman W, Blaschke TF, Hoffman BB. Pharmacological tolerance to alpha 1-adrenergic receptor antagonism mediated by terazosin in humans. J Clin Invest 1992; 90:1763-8.
7. Zhang L, Taniguchi T, Tanaka T et al. Alpha-1 adrenoceptor up-regulation induced by prazosin but not KMD-3213 or reserpine in rats. Br J Pharmacol 2002; 135:1757-64.
8. Bond RA. Is paradoxical pharmacology a strategy worth pursuing? Trends Pharmacol Sci 2001; 22:273-6.
9. Hein P, Goepel M, Cotecchia S, Michel MC. A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol 2001; 363:34-9.
10. Lee TW, Cotecchia S, Milligan G. Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster alpha1B-adrenoceptor by ligands that act as inverse agonists. Biochem J 1997; 325(Pt 3):733-9.
11. Hall SA, Cigarroa CG, Marcoux L, Risser RC, Grayburn PA, Eichhorn EJ. Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with beta-adrenergic blockade. J Am Coll Cardiol 1995; 25:1154-61.
12. Packer M, Bristow MR, Cohn JN et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N Engl J Med 1996; 334:1349-55.
13. Lipworth BJ, Williamson PA. Think the impossible: beta-blockers for treating asthma. Clin Sci (Lond) 2010; 118:115-20.
14. Basu K, Palmer CN, Tavendale R, Lipworth BJ, Mukhopadhyay S. Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol. J Allergy Clin Immunol 2009; 124:1188-93. e3.
15. Lee DK, Currie GP, Hall IP, Lima JJ, Lipworth BJ. The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol. Br J Clin Pharmacol 2004; 57:68-75.
16. Hanania NA, Singh S, El-Wali R et al. The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot study. Pulm Pharmacol Ther 2008; 21:134-41.
17. Short PM, Williamson PA, Anderson WJ, Lipworth BJ. Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma. Am J Respir Crit Care Med 2013; 187:1308-14.
18. Anderson WJ, Short PM, Williamson PA, Manoharan A, Lipworth BJ. The inverse agonist propranolol confers no corticosteroid-sparing activity in mild-to-moderate persistent asthma. Clin Sci (Lond) 2014; 127:635-43.
19. Bousquet J, Khaltaev N, Cruz AA et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008; 63(Suppl 86):8-160.
20. Vincent J, Elliott HL, Meredith PA, Reid JL. Doxazosin, an alpha 1-adrenoceptor antagonist: pharmacokinetics and concentration-effect relationships in man. Br J Clin Pharmacol 1983; 15:719-25.
21. Bousquet PJ, Combescure C, Neukirch F et al. Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines. Allergy 2007; 62:367-72.
22. Juniper EF. Measuring health-related quality of life in rhinitis. J Allergy Clin Immunol 1997; 99:S742-9.
23. Vaidyanathan S, Williamson P, Anderson K, Lipworth B. Effect of systemic steroids on humming nasal nitric oxide in chronic rhinosinusitis with nasal polyposis. Ann Allergy Asthma Immunol 2010; 105:412-7.
24. American Thoracic S. European Respiratory S, ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005; 171:912-30.
25. Barnes ML, Vaidyanathan S, Williamson PA, Lipworth BJ. The minimal clinically important difference in allergic rhinitis. Clin Exp Allergy 2010; 40:242-50.
26. Demoly P, Bousquet PJ, Mesbah K, Bousquet J, Devillier P. Visual analogue scale in patients treated for allergic rhinitis: an observational prospective study in primary care: asthma and rhinitis. Clin Exp Allergy 2013; 43:881-8.