Dependability of results in conference abstracts of randomized controlled trials in ophthalmology and author financial conflicts of interest as a factor associated with full publication

Trials

Volumn 17, Issue 1, 2016, Pages

  Saldanha, Ian J ^a   Scherer, Roberta W ^a   Rodriguez Barraquer, Isabel ^a   Jampel, Henry D ^b   Dickersin, Kay ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFLICT OF INTEREST; CONSULTATION; CONTROLLED STUDY; EMPLOYEE; FINANCIAL MANAGEMENT; HUMAN; HUMAN EXPERIMENT; INVENTOR; OPHTHALMOLOGY; PATENT; PUBLICATION; RISK FACTOR; STATISTICAL SIGNIFICANCE; VISION; BIBLIOMETRICS; COMPARATIVE STUDY; ECONOMICS; ETHICS; ORGANIZATION; PUBLISHING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPRODUCIBILITY; RISK; WRITING;

AUTHORSHIP; BIBLIOMETRICS; CONFLICT OF INTEREST; CONGRESSES AS TOPIC; HUMANS; OPHTHALMOLOGY; PERIODICALS AS TOPIC; PUBLICATION BIAS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REPRODUCIBILITY OF RESULTS; RESEARCH SUPPORT AS TOPIC; RISK;

EID: 84964323814     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/s13063-016-1343-z     Document Type: Article

References (48)

1. Weintraub WH. Are published manuscripts representative of the surgical meeting abstracts? an objective appraisal. J Pediatr Surg. 1987;22:11-3.
2. Gross CP, Steiner CA, Bass EB, Powe NR. Relation between prepublication release of clinical trial results and the practice of carotid endarterectomy. JAMA. 2000;284:2886-93.
3. Falagas ME, Rosmarakis ES. Clinical decision-making based on findings presented in conference abstracts: is it safe for our patients? Eur Heart J. 2006;27(17):2038-9.
4. Institute of Medicine. Finding what works in health care: standards for systematic reviews. March 23, 2011 - available for download as PDF free of charge online at: http://www.iom.edu/Reports/2011/Finding-What-Works-in-Health-Care-Standards-for-Systematic-Reviews.aspx. Accessed 28 Mar 2016.
5. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011. Available: www.cochrane-handbook.org. Accessed 28 Mar 2016.
6. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. AHRQ Publication No. 10(14)-EHC063-EF. Rockville, MD: Agency for Healthcare Research and Quality. January 2014. Chapters available at: www.effectivehealthcare.ahrq.gov. Accessed 28 Mar 2016.
7. Center for Reviews and Dissemination. Systematic reviews: CRD's guidance for undertaking reviews in health care. York, UK: York Publishing Services, Ltd. Available at: https://www.york.ac.uk/media/crd/Systematic_Reviews.pdf. Accessed 28 Mar 2016.
8. Dundar Y, Dodd S, Dickson R, Walley T, Haycox A, Williamson PR. Comparison of conference abstracts and presentations with full-text articles in the health technology assessments of rapidly evolving technologies. Health Technol Assess. 2006;10(5):iii-iv-x-145.
9. Dwan K, Altman DG, Creswell L, Blundell M, Gamble CL, Williamson PR. Comparison of protocols and registry entries to published reports for randomised controlled trials. Cochrane Database Syst Rev. 2011;19(1):MR000031. doi: 10.1002/14651858.MR000031.pub2.
10. Dwan K, Gamble C, Williamson PR, Kirkham JJ, Reporting Bias Group. Systematic review of the empirical evidence of study publication bias and outcome reporting bias - an updated review. PLoS One. 2013;8(7):e66844. doi: 10.1371/journal.pone.0066844.
11. Scherer RW, Huynh L, Ervin A-M, Dickersin K. Using ClinicalTrials.gov to supplement information in ophthalmology conference abstracts about trial outcomes: a comparison study. PLoS One. 2015;10(6):e0130619. doi: 10.1371/journal.pone.0130619.
12. Bhandari M, Devereaux PJ, Guyatt GH, Cook DJ, Swiontkowski MF, Sprague S, et al. An observational study of orthopaedic abstracts and subsequent full-text publications. J Bone Joint Surg Am. 2002;84-A:615-21.
13. Kleweno CP, Bryant WK, Jacir AM, Levine WN, Ahmad CS. Discrepancies and rates of publication in orthopedic sports medicine abstracts. Am J Sports Med. 2008;36(10):1875-9.
14. Toma M, McAlister FA, Bialy L, Adams D, Vandermeer B, Armstrong PW. Transition from meeting abstract to full-length journal article for randomized controlled trials. JAMA. 2006;295:1281-7.
15. Klassen TP, Wiebe N, Russell K, Stevens K, Hartling L, Craig WR, et al. Abstracts of randomized controlled trials presented at the society for pediatric research meeting: an example of publication bias. Arch Pediatr Adolesc Med. 2002;156:474-9.
16. Rosmarakis ES, Soteriades ES, Vergidis PI, Kasiakou SK, Falagas ME. From conference abstract to full paper: differences between data presented in conferences and journals. FASEB J. 2005;19:673-80.
17. Chokkalingam A, Scherer R, Dickersin K. Agreement of data abstracts compared to full publications. Control Clin Trials. 1998;19:61S-2.
18. Scherer RW, Ugarte-Gil C, Schmucker C, Meerpohl JJ. Authors report lack of time as main reason for unpublished research presented at biomedical conferences: a systematic review. J Clin Epidemiol. 2015. doi: 10.1016/j.jclinepi.2015.01.027.
19. Song F, Parekh S, Hooper L, Loke Y, Ryder J, Sutton AJ, et al. Dissemination and publication of research findings: an update of related biases. Health Technol Assess. 2010;14(8):iii. doi: 10.3310/hta14080. ix-xi, 1-193.
20. Scherer RW, Langenberg P, von Elm E. Full publication of results initially presented in abstracts. Cochrane Database Syst Rev. 2007;2:MR000005. doi: 10.1002/14651858.MR000005.pub3.
21. Hopewell S, Loudon K, Clarke MJ, Oxman AD, Dickersin K. Publication bias in clinical trials due to statistical significance of direction of trial result. Cochrane Database Syst Rev. 2009;1:MR000006.
22. Bekelman JE, Li Y, Gross CP. Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA. 2003;289(4):454-65.
23. Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R. Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med. 2008;358(3):252-60.
24. Sismondo S. Pharmaceutical company funding and its consequences: a qualitative systematic review. Contemporay Clinical Trials. 2008;29(2):109-13.
25. Lundh A, Sismondo S, Lexchin J, Busuioc OA, Bero L. Industry sponsorship and research outcome. Cochrane Database Syst Rev. 2012;12:MR000033. doi: 10.1002/14651858.MR000033.pub2.
26. Thompson D. Understanding financial conflicts of interest. N Engl J Med. 1993;329:573-6.
27. International Committee of Medical Journal Editors (ICMJE). Author responsibilities-Conflicts of interest. Available at http://www.icmje.org/recommendations/browse/roles-and-responsibilities/author-responsibilities--conflicts-of-interest.html. Accessed 28 Mar 2016.
28. Bland JM, Altman DG. The logrank test. BMJ. 2004;328(7447):1073.
29. Chan AW, Song F, Vickers A, Jefferson T, Dickersin K, Gøtzsche PC, et al. Increasing value and reducing waste: addressing inaccessible research. Lancet. 2014;383(9913):257-66.
30. Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet. 2009;374(9683):86-9.
31. Macleod MR, Michie S, Roberts I, Dirnagl U, Chalmers I, Ioannidis JP, et al. Biomedical research: increasing value, reducing waste. Lancet. 2014;383(9912):101-4.
32. Chalmers I. Underreporting research is scientific misconduct. JAMA. 1990;263:1405-8.
33. Antes G, Chalmers I. Under-reporting of clinical trials is unethical. Lancet. 2003;361:978-9.
34. von Elm E, Costanza MC, Walder B, Tramèr MR. More insight into the fate of biomedical meeting abstracts: a systematic review. BMC Med Res Methodol. 2003;3(1):12.
35. Hopewell S, Clarke M, Moher D, Wager E, Middleton P, Altman DG, et al. CONSORT for reporting randomised trials in journal and conference abstracts. Lancet. 2008;371(9609):281-3.
36. Ghimire S, Kyung E, Kang W, Kim E. Assessment of adherence to the CONSORT statement for quality of reports on randomized controlled trial abstracts from four high-impact general medical journals. Trials. 2012;13:77. doi: 10.1186/1745-6215-13-77.
37. Sivendran S, Newport K, Horst M, Albert A, Galsky MD. Reporting quality of abstracts in phase III clinical trials of systemic therapy in metastatic solid malignancies. Trials. 2015;16:341. doi: 10.1186/s13063-015-0885-9.
38. Wang L, Li Y, Li J, Zhang M, Xu L, Yuan W, et al. Quality of reporting of trial abstracts needs to be improved: using the CONSORT for abstracts to assess the four leading Chinese medical journals of traditional Chinese medicine. Trials. 2010;11:75. doi: 10.1186/1745-6215-11-75.
39. Korevaar DA, Cohen JF, de Ronde MW, Virgili G, Dickersin K, Bossuyt PM. Reporting weaknesses in conference abstracts of diagnostic accuracy studies in ophthalmology. JAMA Ophthalmol. 2015;8:1-5. doi: 10.1001/jamaophthalmol.2015.3577.
40. Campbell EG, Louis KS, Blumenthal D. Looking a gift horse in the mouth: corporate gifts support life sciences research. JAMA. 1998;279:995-9.
41. Rochon PA, Sekeres M, Hoey J, Lexchin J, Ferris LE, Moher D, et al. Investigator experiences with financial conflicts of interest in clinical trials. Trials. 2011;12:9. doi: 10.1186/1745-6215-12-9.
42. Neuman J, Korenstein D, Ross JS, Keyhani S. Prevalence of financial conflicts of interest among panel members producing clinical practice guidelines in Canada and United States: cross sectional study. BMJ. 2011;343:d5621. doi: 10.1136/bmj.d5621.
43. Johnston J. "Conflict of Interest in Biomedical Research,". In: Crowley M, editor. From Birth to Death and Bench to Clinic: The Hastings Center Bioethics Briefing Book for Journalists, Policymakers, and Campaigns. Garrison, NY: The Hastings Center; 2008. p. 31-4.
44. Kjaergard LL, Als-Nielsen B. Association between competing interest and authors' conclusions: epidemiological study of randomised clinical trials published in the BMJ. BMJ. 2002;325(7358):249.
45. Okike K, Kocher MS, Wei EX, Mehlman CT, Bhandari M. Accuracy of conflict-of-interest disclosures reported by physicians. New Eng J Med. 2009;361(15):1466-74.
46. Sismondo S. Ghosts in the machine: publication planning in the medical sciences. Soc Stud Sco. 2009;39(2):171-98.
47. Roseman M, Millette K, Bero LA, Coyne JC, Lexchin J, Turner EH, et al. Reporting of conflicts of interest in meta-analyses of trials of pharmacological treatments. JAMA. 2011;305:1008-17.
48. Moynihan R. Key opinion leaders: independent experts or drug representatives in disguise? BMJ. 2008;336(7658):1402-3.