Intratubular germ cell neoplasia of the human testis: Heterogeneous protein expression and relation to invasive potential

Modern Pathology

Volumn 27, Issue 9, 2014, Pages 1255-1266

  Mitchell, Rod T ^a,b   Camacho Moll, Maria E ^a   Macdonald, Joni ^a   Anderson, Richard A ^a   Kelnar, Christopher J H ^b   O'Donnell, Marie ^c   Sharpe, Richard M ^a   Smith, Lee B ^a   Grigor, Ken M ^c   Wallace, W Hamish B ^b   Stoop, Hans ^d   Wolffenbuttel, Katja P ^d   Donat, Roland ^c   Saunders, Philippa T K ^a   Looijenga, Leendert H J ^d  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

Author keywords

Carcinoma in situ; Cell differentiation; Cell proliferation; Germ cells; Testicular germ cell tumors

Indexed keywords

KI 67 ANTIGEN; MAGEA4 PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PLAP PROTEIN; PROTEIN; TRANSCRIPTION FACTOR AP 2; UNCLASSIFIED DRUG; VASA PROTEIN; BIOLOGICAL MARKER; TUMOR ANTIGEN; TUMOR MARKER; TUMOR PROTEIN;

ADULT; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FETUS; GERM CELL TUMOR; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERMATOGENESIS; SPERMATOGONIUM; STEREOLOGY; CELL DIFFERENTIATION; CHILD; EMBRYOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; INFANT; METABOLISM; NEOPLASM; PATHOLOGY; SEMINIFEROUS TUBULE; SEMINOMA; TESTIS; TESTIS TUMOR; TUMOR INVASION; YOUNG ADULT;

ADULT; ANTIGENS, NEOPLASM; BIOMARKERS; BIOMARKERS, TUMOR; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILD; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GERMINOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MALE; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASMS, GERM CELL AND EMBRYONAL; SEMINIFEROUS TUBULES; SEMINOMA; SPERMATOGONIA; TESTICULAR NEOPLASMS; TESTIS; YOUNG ADULT;

EID: 84964314435     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.246     Document Type: Article

References (32)

1. McGlynn KA, Devesa SS, Sigurdson AJ, et al. Trends in the incidence of testicular germ cell tumors in the United States. Cancer 2003;97:63-70.
2. Richiardi L, Bellocco R, Adami HO, et al. Testicular cancer incidence in eight northern European countries: secular and recent trends. Cancer Epidemiol Biomarkers Prev 2004;13:2157-2166.
3. Rajpert-De Meyts E. Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects. Hum Reprod Update 2006;12:303-323.
4. Skakkebaek NE. Possible carcinoma-in-situ of the testis. Lancet 1972;2:516-517.
5. Waters BL, Trainer TD. Development of the human fetal testis. Pediatr Pathol Lab Med 1996;16:9-23.
6. Hoei-Hansen CE, Almstrup K, Nielsen JE, et al. Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. Histopathology 2005;47:48-56.
7. Mitchell RT, Cowan G, Morris KD, et al. Germ cell differentiation in the marmoset (Callithrix jacchus) during fetal and neonatal life closely parallels that in the human. Hum Reprod 2008;23:2755-2765.
8. Hoei-Hansen CE, Nielsen JE, Almstrup K, et al. Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors. Clin Cancer Res 2004;10:8521-8530.
9. Jorgensen N, Rajpert-De Meyts E, Graem N, et al. Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells. Lab Invest 1995;72:223-231.
10. Mitchell RT, Saunders PT, Childs AJ, et al. Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation. Hum Reprod 2010;25:2405-2414.
11. Oosterhuis JW, Looijenga LH. Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 2005;5:210-222.
12. Jorgensen A, Nielsen JE, Almstrup K, et al. Dysregulation of the mitosis-meiosis switch in testicular carcinoma in situ. J Pathol 2013;229:588-598.
13. Kersemaekers AM, Honecker F, Stoop H, et al. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum Pathol 2005;36:512-521.
14. Norton AJ, Jordan S, Yeomans P. Brief, high-temperature heat denaturation (pressure cooking): a simple and effective method of antigen retrieval for routinely processed tissues. J Pathol 1994;173:371-379.
15. Skakkebaek NE, Berthelsen JG, Giwercman A, et al. Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl 1987;10:19-28.
16. Almstrup K, Hoei-Hansen CE, Wirkner U, et al. Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling. Cancer Res 2004;64:4736-4743.
17. Looijenga LH, Gillis AJ, Stoop HJ, et al. Chromosomes and expression in human testicular germ-cell tumors: insight into their cell of origin and pathogenesis. Ann N Y Acad Sci 2007;1120:187-214.
18. Jones TD, Ulbright TM, Eble JN, et al. OCT4: a sensitive and specific biomarker for intratubular germ cell neoplasia of the testis. Clin Cancer Res 2004;10:8544-8547.
19. Looijenga LH, Stoop H, de Leeuw HP, et al. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res 2003;63:2244-2250.
20. Rajpert-De Meyts E, Hanstein R, Jorgensen N, et al. Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads. Hum Reprod 2004;19:1338-1344.
21. Hustin J, Collette J, Franchimont P. Immunohistochemical demonstration of placental alkaline phosphatase in various states of testicular development and in germ cell tumours. Int J Androl 1987;10:29-35.
22. Cools M, van Aerde K, Kersemaekers AM, et al. Morphological and immunohistochemical differences between gonadal maturation delay and early germ cell neoplasia in patients with undervirilization syndromes. J Clin Endocrinol Metab 2005;90:5295-5303.
23. Honecker F, Stoop H, de Krijger RR, et al. Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. J Pathol 2004;203:849-857.
24. Gaskell TL, Esnal A, Robinson LL, et al. Immunohistochemical profiling of germ cells within the human fetal testis: identification of three subpopulations. Biol Reprod 2004;71:2012-2021.
25. Rajpert-De Meyts E, Bartkova J, Samson M, et al. The emerging phenotype of the testicular carcinoma in situ germ cell. APMIS 2003;111:267-278; discussion 278-269.
26. Aubry F, Satie AP, Rioux-Leclercq N, et al. MAGEA4, a germ cell specific marker, is expressed differentially in testicular tumors. Cancer 2001;92:2778-2785.
27. Castrillon DH, Quade BJ, Wang TY, et al. The human VASA gene is specifically expressed in the germ cell lineage. Proc Natl Acad Sci USA 2000;97:9585-9590.
28. Zeeman AM, Stoop H, Boter M, et al. VASA is a specific marker for both normal and malignant human germ cells. Lab Invest 2002;82:159-166.
29. Albers P, Ulbright TM, Albers J, et al. Tumor proliferative activity is predictive of pathological stage in clinical stage A nonseminomatous testicular germ cell tumors. J Urol 1996;155:579-586.
30. Almstrup K, Nielsen JE, Mlynarska O, et al. Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells. Br J Cancer 2010;103:1269-1276.
31. Datta MW, Renshaw AA, Dutta A, et al. Evaluation of cyclin expression in testicular germ cell tumors: cyclin E correlates with tumor type, advanced clinical stage, and pulmonary metastasis. Mod Pathol 2000;13:667-672.
32. Chen YT, Cao D, Chiu R, et al. Chromosome X-encoded cancer/testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas. Cancer Immun 2013;13:10.