Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 4, 2015, Pages 767-774

  Chen, Jian Jeffrey ^a   Liu, Qingyian ^a   Yuan, Chester ^a   Gore, Vijay ^a   Lopez, Patricia ^a   Ma, Vu ^a   Amegadzie, Albert ^a   Qian, Wenyuan ^a   Judd, Ted C ^a   Minatti, Ana E ^a   Brown, James ^a   Cheng, Yuan ^a   Xue, May ^a   Zhong, Wenge ^a   Dineen, Thomas A ^a   Epstein, Oleg ^a   Human, Jason ^a   Kreiman, Charles ^a   Marx, Isaac ^a   Weiss, Matthew M ^a   Hitchcock, Stephen A ^a   Powers, Timothy S ^a   Chen, Kui ^a   Wen, Paul H ^a   Whittington, Douglas A ^a   Cheng, Alan C ^a   Bartberger, Michael D ^a   Hickman, Dean ^a   Werner, Jonathan A ^a   Vargas, Hugo M ^a   Everds, Nancy E ^a   Vonderfecht, Steven L ^a   Dunn, Robert T ^a   Wood, Stephen ^a   Fremeau, Robert T ^a   White, Ryan D ^a   Patel, Vinod F ^a   more..

^a AMGEN INC   (United States)

Author keywords

3 Azaxanthene; Alzheimer's disease (AD); Aminooxazoline; Amyloid; A peptides; Xanthene; Secretase (BACE1)

Indexed keywords

2 AMINOOXAZOLINE 3 AZAXANTHENE DERIVATIVE; BETA SECRETASE INHIBITOR; UNCLASSIFIED DRUG; XANTHENE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; BRAIN LEVEL; CEREBROSPINAL FLUID; DRUG DESIGN; DRUG EFFICACY; MALE; NONHUMAN; QT PROLONGATION; RAT;

PRIMATES; RATTUS;

EID: 84964311489     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.12.092     Document Type: Article

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