The effect of autologous concentrated bone-marrow grafting on the healing of femoral shaft non-unions after locked intramedullary nailing

Injury

Volumn 45, Issue S5, 2014, Pages S7-S13

  Guimarães, João Antonio Matheus ^a   Duarte, Maria Eugenia L ^a   Fernandes, Marco B Cury ^a   Vianna, Verônica F ^a   Rocha, Tito H N ^a   Bonfim, Danielle C ^a   Casado, Priscila L ^a   Guimarães, Isabel C C Do Val ^b   Velarde, Luis G Coca ^b   Dutra, Hélio S ^c   Giannoudis, Peter V ^d,e  

^a Instituto Nacional de Traumatologia e Ortopedia (INTO)   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e CHAPEL ALLERTON HOSPITAL   (United Kingdom)

Author keywords

Bone marrow grafting; Femoral shaft fracture; Fracture healing; Intramedullary nailing; Non union

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; AUTOTRANSPLANTATION; BONE DEVELOPMENT; BONE MARROW BIOPSY; BONE MARROW TRANSPLANTATION; BONE RADIOGRAPHY; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; CLINICAL EXAMINATION; COMPUTER ASSISTED TOMOGRAPHY; CONCENTRATION PROCESS; FEMALE; FEMORAL FRACTURES; FEMORAL SHAFT NON UNION; FOLLOW UP; FRACTURE HEALING; FRACTURE NONUNION; FRACTURES, UNUNITED; GENERAL ANESTHESIA; HUMAN; INTRAMEDULLARY NAILING; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PATIENT HISTORY OF SURGERY; POSTOPERATIVE COMPLICATION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RADIOGRAPHIC UNION SCALE IN TIBIAL; RADIOGRAPHY; REOPERATION; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; SURGERY; TIBIA FRACTURE; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; BONE MARROW TRANSPLANTATION; FEMALE; FEMORAL FRACTURES; FOLLOW-UP STUDIES; FRACTURE FIXATION, INTRAMEDULLARY; FRACTURE HEALING; FRACTURES, UNUNITED; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; OSTEOGENESIS; PHYSIOPATHOLOGY; RADIOGRAPHY; REOPERATION; STATISTICS AND NUMERICAL DATA; SURGERY; TOMOGRAPHY, X-RAY COMPUTED; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME;

EID: 84964262063     PISSN: 00201383     EISSN: 18790267     Source Type: Journal    
DOI: 10.1016/S0020-1383(14)70013-0     Document Type: Article

References (71)

1. M Ronga, A Fagetti, G Canton, E Paiusco, MF Surace, P Cherubino Clinical applications of growth factors in bone injuries: experience with BMPs Injury 44 Suppl 1 2013 S34 S39
2. Y Homma, G Zimmermann, P Hernigou Cellular therapies for the treatment of non-union: the past, present and future Injury 44 Suppl 1 2013 S46 S49
3. GM Calori, E Mazza, M Colombo, S Mazzola, GV Mineo, PV Giannoudis Treatment of AVN using the induction chamber technique and a biological-based approach: indications and clinical results Injury 45 2014 369 373
4. GM Calori, M Colombo, E Mazza, C Ripamonti, S Mazzola, N Marelli, GV Mineo Monotherapy vs. polytherapy in the treatment of forearm non-unions and bone defects Injury 44 Suppl 1 2013 S63 S69
5. PV Giannoudis, GM Calori, T Begue, G Schmidmaier Bone regeneration strategies: current trends but what the future holds? Injury 44 Suppl 1 2013 S1 S2
6. TJ Blokhuis, GM Calori, G Schmidmaier Autograft versus BMPs for the treatment of non-unions: what is the evidence? Injury 44 Suppl 1 2013 S40 S42
7. PV Giannoudis, MA Ahmad, GV Mineo, TI Tosounidis, GM Calori, NK Kanakaris Subtrochanteric fracture non-unions with implant failure managed with the "Diamond" concept Injury 44 Suppl 1 2013 S76 S81
8. A Praemer, S Furner, DP Rice Musculoskeletal Conditions in the United States 1999 American Academy of Orthopaedic Surgeons Rosemont
9. C Tzioupis, PV Giannoudis Prevalence of long-bone non-unions Injury 38 Suppl 2 2007 S3 S9
10. TA Einhorn, RJ Majeska, EB Rush, PM Levine, MC Horowitz The expression of cytokine activity by fracture callus J Bone Miner Res 10 1995 1272 1281
11. PV Giannoudis, TA Einhorn, D Marsh Fracture healing: a harmony of optimal biology and optimal fixation? Injury 38 Suppl 4 2007 S1 S2
12. CT Laurencin, TA Einhorn, K Lyons Fracture repair: challenges and opportunities J Bone Joint Surg Am 90 Suppl 1 2008 1 2
13. PV Giannoudis, TA Einhorn, G Schmidmaier, D Marsh The diamond concept - open questions Injury 39 Suppl 2 2008 S5 S8
14. rd ed. 1994 JB Lippincott Philadelphia 183 211
15. PV Giannoudis, DA MacDonald, SJ Matthews, RM Smith, AJ Furlong, P De Boer Nonunion of the femoral diaphysis. The influence of reaming and non-steroidal anti-inflammatory drugs J Bone Joint Surg Br 82B 2000 655 658
16. P Tornetta III, D Tiburzi Antegrade or retrograde reamed femoral nailing. A prospective, randomised trial J Bone Joint Surg Br 82 2000 652 654
17. RA Winquist, ST Hansen Jr, DK Clawson Closed intramedullary nailing of femoral fractures: a report of five hundred and twenty cases J Bone Joint Surg Am 66 1984 529 539
18. AM Eid, AI Deif Aetiological factors in non-union following Kuntscher intramedullary nailing of the femur Arch Orthop Trauma Surg 96 1980 213 220
19. HK Pihlajamäki, ST Salminen, OM Böstman The treatment of nonunions following intramedullary nailing of femoral shaft fractures J Orthop Trauma 16 2002 394 402
20. D Ring, WT Barrick, JB Jupiter Recalcitrant nonunion Clin Orthop Relat Res 340 1997 181 189
21. AJ Furlong, PV Giannoudis, P DeBoer, SJ Matthews, DA MacDonald, RM Smith Exchange nailing for femoral shaft aseptic non-union Injury 30 1999 245 249
22. TA Einhorn, RJ Majeska, A Mohaideen, EM Kagel, ML Bouxsein, TJ Turek et al. A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair J Bone Joint Surg Am 85-A 2003 1425 1435
23. CW Yu, CC Wu, WJ Chen Aseptic nonunion of a femoral shaft treated using exchange nailing Chang Gung Med J 25 2002 591 598
24. BA Zelle, GS Gruen, B Klatt, MJ Haemmerle, WJ Rosenblum, MJ Prayson Exchange reamed nailing for aseptic nonunion of the tibia J Trauma 57 2004 1053 1059
25. MR Brinker, DP O'Connor Exchange nailing of ununited fractures J Bone Joint Surg Am 89 2007 177 188
26. LL Johnson, KM Morrison, DL Wood The application of arthroscopic principles to bone grafting of delayed union of long bone fractures Arthroscopy 16 2000 279 289
27. CB Jones, KA Mayo Nonunion treatment: iliac crest bone graft techniques J Orthop Trauma 19 2005 S11 S13
28. GE Friedlaender, CR Perry, JD Cole, SD Cook, G Cierny, GF Muschler et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions J Bone Joint Surg Am 83-A 2001 S151 S158
29. TA Einhorn, RJ Majeska, A Mohaideen, EM Kagel, ML Bouxsein, TJ Turek et al. A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair J Bone Joint Surg Am 85-A 2003 1425 1435
30. GE Friedlaender Osteogenic protein-1 in the treatment of tibial nonunions: current status Surg Technol Int 13 2004 249 252
31. AP White, AR Vaccaro, JA Hall, PG Whag, BC Friel, MD McKee Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion Int Orthop 31 2007 735 741
32. JO Hollinger, CE Hart, SN Hirsch, S Lynch, GE Friedlaender Recombinant human platelet-derived growth factor: biology and clinical applications J Bone Joint Surg Am 90-A 2008 48 54
33. BH Ziran, WR Smith, SJ Morgan Use of calcium-based demineralized bone matrix/allograft for nonunions and posttraumatic reconstruction of the appendicular skeleton: preliminary results and complications J Trauma 63 2007 1324 1328
34. P Hernigou, A Poignard, F Beaujean, H Rouard Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells J Bone Joint Surg Am 87 2005 1430 1437
35. MR Brinker Nonunions: evaluation and treatment BD Browner JB Jupiter AM Levine PG Trafton 3rd ed Skeletal Trauma: basic science management and reconstruction vol. 1 2003 Saunders Philadelphia 507 604
36. BW Kooistra, BG Dijkman, JW Busse, S Sprague, EH Schemitsch, M Bhandari The radiographic union scale in tibial fractures: reliability and validity J Orthop Trauma 24 2010 S81 S86
37. GF Muschler, C Boehm, K Easley Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume J Bone Joint Surg Am 79 1997 1699 1709
38. P Hernigou, G Mathieu, A Poignard, O Manicom, F Beaujean, H Rouard Percutaneous autologous bone-marrow grafting for nonunions: surgical technique J Bone Joint Surg Am 88 Suppl 1 2006 322 327
39. RB Gustilo, JT Anderson Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses J Bone Joint Surg Am 58 1976 453 458
40. JL Marsh, TF Slongo, J Agel, JS Broderick, W Ceevey, TA DeCoster et al. Fracture and dislocation classification compendium - 2007: Orthopaedic Trauma Association Classification, Database and Outcomes Committee J Orthop Trauma 21 2007 S1 133
41. DJ Crowley, NK Kanakaris, PV Giannoudis Femoral diaphyseal aseptic non-unions: is there an ideal method of treatment? Injury 38 Suppl 2 2007 55 63
42. CC Wu, WJ Chen Treatment of femoral shaft aseptic nonunions: comparison between closed and open bone-grafting techniques J Trauma 43 1997 112 116
43. DJ Hak, SS Lee, JA Goulet Success of exchange reamed intramedullary nailing for femoral shaft nonunion or delayed union J Orthop Trauma 14 2000 178 182
44. MJ Weresh, R Hakanson, MD Stover, SH Sims, JF Kellam, MJ Bosse Failure of exchange reamed intramedullary nails for ununited femoral shaft fractures J Orthop Trauma 14 2000 335 338
45. CC Wu, WJ Chen Exchange nailing for aseptic nonunion of the femoral shaft Int Orthop 26 2002 80 84
46. HK Pihlajamäki, ST Salminen, OM Böstman The treatment of nonunions following intramedullary nailing of femoral shaft fractures J Orthop Trauma 16 2002 394 402
47. PA Banaszkiewicz, A Sabboubeh, I McLeod, N Maffulli Femoral exchange nailing for aseptic non-union: not the end to all problems Injury 34 2003 349 356
48. CG Finkemeier, MW Chapman Treatment of femoral diaphyseal nonunions Clin Orthop Relat Res 398 2002 223 234
49. JE Shroeder, R Mosheiff, A Khoury, M Liebergall, YA Weil The outcome of closed, intramedullary exchange nailing with reamed insertion in the treatment of femoral shaft nonunions J Orthop Trauma 23 2009 653 657
50. GM Calori, PV Giannoudis Enhancement of fracture healing with the diamond concept: the role of the biological chamber Injury 42 2011 1191 1193
51. JF Connolly, R Shindell Percutaneous marrow injection for an ununited tibia Nebr Med J 71 1986 105 107
52. JF Connolly, R Guse, J Tiedeman, R Dehne Autologous marrow injection as a substitute for operative grafting of tibial nonunions Clin Orthop Relat Res 266 1991 259 270
53. NK Garg, S Gaur, S Sharma Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture Acta Orthop Scand 64 1993 671 672
54. B Sebecic, V Gabelica, L Patrlj, T Sosa Percutaneous autologous bone marrow grafting on the site of tibial delayed union Croat Med J 40 1999 429 432
55. RC Siwach, SS Sangwan, R Singh, A Goel Role of percutaneous bone marrow grafting in delayed unions, nonunions and poor regenerates Indian J Med Sci 55 2001 326 336
56. L Wang, WS Li, QS Zhang Autogenous bone marrow graft for the management of nonunion of tibia Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 15 2001 24 25
57. A Goel, SS Sangwann, RC Siwach, AM Ali Percutaneous bone marrow grafting for the treatment of tibial non-union Injury 36 2005 203 206
58. Y Matsuda, K Sakayama, H Okumura, Y Kawatani, N Mashima, T Shibata Percutaneous autologous bone marrow transplantation for nonunion of the femur Nippon Geka Hokan 67 1998 10 17
59. RM Wilkins, BT Chimenti, RM Rifkin Percutaneous treatment of long bone nonunions: the use of autologous bone marrow and allograft bone matrix Orthopedics 26 Suppl 5 2003 S549 S554
60. R Sim, TS Liang, BK Tay Autologous marrow injection in the treatment of delayed and non-union in long bones Singapore Med J 34 1993 412 417
61. MK Sen, T Miclau Autologous iliac crest bone graft: should it still be the gold standard for treating nonunions? Injury 38 2007 75S 80S
62. P Tetreault, HA Ouellette Healing of a clavicle fracture nonunion with bone marrow injection J Shoulder Elbow Surg 16 2007 23e 24e
63. GF Muschler, C Boehm, K Easley Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume J Bone Joint Surg Am 79 1997 1699 1709 Erratum in: J Bone Joint Surg Am 1998;80:302
64. P Hernigou, F Beaujean Treatment of osteonecrosis with autologous bone marrow grafting Clin Orthop Relat Res 405 2002 14 23
65. P Hernigou, F Beaujean Progeniteurs ostéoblastiques de la moelle osseuse des crêtes iliaques: leur variation en fonction de la pathologie, de l'âge, du sexe Rev du Rhum 70 2003 949 950
66. GF Muschler, H Nitto, CA Boehm, KA Easley Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors J Orthop Res 19 2001 117 125
67. P Hernigou, F Beaujean Abnormalities in the bone marrow of the iliac crest in patients who have osteonecrosis secondary to corticosteroid therapy or alcohol abuse J Bone Joint Surg Am 79 1997 1047 1053
68. R Quarto, D Thomas, CT Liang Bone progenitor cell deficits and the age-associated decline in bone repair capacity Calcif Tissue Int 56 1995 123 129
69. G D'Ippolito, PC Schiller, C Ricordi, BA Roos, GA Howard Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow J Bone Miner Res 14 1999 1115 1122
70. DG Phinney, G Kopen, W Righter, S Webster, N Tremain, DJ Prockop Donor variation in the growth properties and osteogenic potential of human marrow stromal cells J Cell Biochem 75 1999 424 436
71. R Siddappa, R Licht, C van Blitterswijk, J de Boer Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering J Orthop Res 25 2007 1029 1041