Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats

Phytomedicine

Volumn 22, Issue 2, 2015, Pages 283-289

  Guo, Chao ^a   Yin, Ying ^a   Duan, Jialin ^a   Zhu, Yanrong ^a   Yan, Jiajia ^a   Wei, Guo ^a   Guan, Yue ^a   Wu, Xiaoxiao ^a   Wang, Yanhua ^a   Xi, Miaomaio ^a   Wen, Aidong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Akt; Apoptosis; Cerebral ischemia reperfusion; GSK 3 ; Sodium danshensu

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; CASPASE 3; CASPASE 7; DAN-SHEN ROOT EXTRACT; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; HERBACEOUS AGENT; NEUROPROTECTIVE AGENT; PHARMACOLOGY; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SODIUM DANSHENSU; UNCLASSIFIED DRUG;

ADULT; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTICLE; BODY TEMPERATURE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CASPASE ASSAY; CEREBRAL ARTERY DISEASE; CHEMISTRY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECTS; DRUG MECHANISM; DRUG THERAPY; ENZYME ACTIVATION; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; MIDDLE CEREBRAL ARTERY OCCLUSION; MODIFIED NEUROLOGICAL SEVERITY SCORE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROLOGIC DISEASE ASSESSMENT; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PATHOLOGY; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; SURVIVAL RATE; TREATMENT RESPONSE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BRAIN ISCHEMIA; CEREBRAL CORTEX; CHEMISTRY; DRUG EFFECTS; DRUG THERAPY; DRUGS, CHINESE HERBAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; METABOLISM; NEUROPROTECTIVE AGENTS; PATHOLOGY; PHARMACOLOGY; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84964247760     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.12.001     Document Type: Article

References (35)

1. Benchoua A., Guegan C., Couriaud C., Hosseini H., Sampaio N., Morin D., Onteniente B. Specific caspase pathways are activated in the two stages of cerebral infarction J. Neurosci. 21 2001 7127 7134
2. Broughton B.R., Reutens D.C., Sobey C.G. Apoptotic mechanisms after cerebral ischemia Stroke 40 2009 e331 e339
3. Chacon M.R., Jensen M.B., Sattin J.A., Zivin J.A. Neuroprotection in cerebral ischemia: emphasis on the SAINT trial Curr. Cardiol. Rep. 10 2008 37 42
4. Chen J., Li Y., Wang L., Zhang Z., Lu D., Lu M., Chopp M. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats Stroke 32 2001 1005 1011
5. Chen Y.S., Lee S.M., Lin Y.J., Chiang S.H., Lin C.C. Effects of Danshensu and salvianolic acid B from Salvia miltiorrhiza Bunge (Lamiaceae) on cell proliferation and collagen and melanin production Molecules 19 2014 2029 2041
6. Chong C.M., Zhou Z.Y., Razmovski-Naumovski V., Cui G.Z., Zhang L.Q., Sa F., Hoi P.M., Chan K., Lee S.M. Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish Neurosci. Lett. 543 2013 121 125
7. Endo H., Nito C., Kamada H., Nishi T., Chan P.H. Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats J. Cereb. Blood Flow Metab. 26 2006 1479 1489
8. Fan G.W., Gao X.M., Wang H., Zhu Y., Zhang J., Hu L.M., Su Y.F., Kang L.Y., Zhang B.L. The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS J. Steroid Biochem. Mol. Biol. 113 2009 275 280
9. Fukunaga K., Kawano T. Akt is a molecular target for signal transduction therapy in brain ischemic insult J. Pharmacol. Sci. 92 2003 317 327
10. Gao Y., Liu Z., Li G., Li C., Li M., Li B. Acute and subchronic toxicity of danshensu in mice and rats Toxicol. Mech. Methods 19 2009 363 368
11. Gu J.F., Feng L., Zhang M.H., Qin D., Jiang J., Cheng X.D., Ding S.M., Yang S.L., Jia X.B. New metabolite profiles of Danshensu in rats by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 955-956 2014 20 25
12. Guo C., Tong L., Xi M., Yang H., Dong H., Wen A. Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats J. Ethnopharmacol. 144 2012 768 774
13. Hanada M., Feng J., Hemmings B.A. Structure, regulation and function of PKB/AKT - a major therapeutic target Biochim. Biophys. Acta 1697 2004 3 16
14. Jope R.S., Johnson G.V. The glamour and gloom of glycogen synthase kinase-3 Trends Biochem. Sci. 29 2004 95 102
15. Lam F.F., Yeung J.H., Chan K.M., Or P.M. Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels Vasc. Pharmacol. 46 2007 271 277
16. Liang K., Ye Y., Wang Y., Zhang J., Li C. Formononetin mediates neuroprotection against cerebral ischemia/reperfusion in rats via downregulation of the Bax/Bcl-2 ratio and upregulation PI3K/Akt signaling pathway J. Neurol. Sci. 344 2014 100 104
17. Liu G., Song J., Guo Y., Wang T., Zhou Z. Astragalus injection protects cerebral ischemic injury by inhibiting neuronal apoptosis and the expression of JNK3 after cerebral ischemia reperfusion in rats Behav. Brain Funct. 9 2013 36
18. Liu G., Wang T., Wang T., Song J., Zhou Z. Effects of apoptosis-related proteins caspase-3, Bax and Bcl-2 on cerebral ischemia rats Biomed. Rep. 1 2013 861 867
19. Liu R., Yu X., Gao W., Ji D., Yang F., Li X., Chen J., Tao H., Huang H., Yi P. Study on the interaction between salvianic acid A sodium and bovine serum albumin by spectroscopic methods Spectrochim. Acta A Mol. Biomol. Spectrosc. 78 2011 1535 1539
20. Lu H., Tian A., Wu J., Yang C., Xing R., Jia P., Yang L., Zhang Y., Zheng X., Li Z. Danshensu inhibits beta-adrenergic receptors-mediated cardiac fibrosis by ROS/p38 MAPK axis Biol. Pharm. Bull. 37 2014 961 967
21. Matayoshi H., Hirata T., Yamashita S., Ishida K., Mizukami Y., Gondo T., Matsumoto M., Sakabe T. Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats Brain Res. 1259 2009 98 106
22. Qin A.P., Zhang H.L., Qin Z.H. Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death Neurosci. Bull. 24 2008 117 123
23. Ren Z.H., Tong Y.H., Xu W., Ma J., Chen Y. Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression Phytomedicine 17 2010 212 218
24. Salakou S., Kardamakis D., Tsamandas A.C., Zolota V., Apostolakis E., Tzelepi V., Papathanasopoulos P., Bonikos D.S., Papapetropoulos T., Petsas T., Dougenis D. Increased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis In Vivo 21 2007 123 132
25. Sun B., Chen L., Wei X., Xiang Y., Liu X., Zhang X. The Akt/GSK-3beta pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats Biochem. Biophys. Res. Commun. 409 2011 808 813
26. Wallgren M., Lidman M., Pedersen A., Brannstrom K., Karlsson B.G., Grobner G. Reconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax protein PLoS One 8 2013 e61452
27. Wang G.H., Lan R., Zhen X.D., Zhang W., Xiang J., Cai D.F. An-Gong-Niu-Huang Wan protects against cerebral ischemia induced apoptosis in rats: up-regulation of Bcl-2 and down-regulation of Bax and caspase-3 J. Ethnopharmacol. 154 2014 156 162
28. Wu L., Qiao H., Li Y., Li L. Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats Phytomedicine 14 2007 652 658
29. Wu W.Y., Wang Y.P. Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components Acta Pharmacol. Sin. 33 2012 1119 1130
30. Yeung J.H.K. New results on the pharmacology and clinical use of the TCM-drug Salvia miltiorrhiza Wagner H. Bauer R. Melchart D. Xiao P.G. Staudinger A. Chromatographic Fingerprint Analysis of Herbal Medicines 2013 Springer Wien New York 237 282
31. Yin Y., Guan Y., Duan J., Wei G., Zhu Y., Quan W., Guo C., Zhou D., Wang Y., Xi M., Wen A. Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation Eur. J. Pharmacol. 699 2013 219 226
32. Yu P.F., Wang W.Y., Eerdun G., Wang T., Zhang L.M., Li C., Fu F.H. The role of P-glycoprotein in transport of Danshensu across the blood-brain barrier Evid. Based Complement. Alternat. Med. 2011 2011 713523
33. Yuan L.B., Dong H.L., Zhang H.P., Zhao R.N., Gong G., Chen X.M., Zhang L.N., Xiong L. Neuroprotective effect of orexin-A is mediated by an increase of hypoxia-inducible factor-1 activity in rat Anesthesiology 114 2011 340 354
34. Zhang N., Zou H., Jin L., Wang J., Zhong M.F., Huang P., Gu B.Q., Mao S.L., Zhang C., Chen H. Biphasic effects of sodium danshensu on vessel function in isolated rat aorta Acta Pharmacol. Sin. 31 2010 421 428
35. Zhang J., Deng Z., Liao J., Song C., Liang C., Xue H., Wang L., Zhang K., Yan G. Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway J. Cereb. Blood Flow Metab. 33 2013 567 574