Investigating the effect of hydroalcoholic extract of Cyperus rotundus L. On the expression of Bcl-xLantiapoptotic gene in rats’ hippocampus tissue following global ischemic-reperfusion injury

Acta Medica Iranica

Volumn 54, Issue 4, 2016, Pages 256-260

  Farahani, Kobra ^a   Hashemi, Mehrdad ^b  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Apoptosis; bcl xl gene; Cyprus rotundus L; Ischemia reperfusion; Real time PCR

Indexed keywords

COMPLEMENTARY DNA; CYPERUS ROTUNDUS EXTRACT; METHANOL; PENTOBARBITAL; PROTEIN BCL XL; PROTEIN BCL X;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BCL XL ANTIAPOPTOTIC GENE; BRAIN; BRAIN ISCHEMIA; CONTROLLED STUDY; GEL ELECTROPHORESIS; GENE; GENE EXPRESSION; HIGH RESOLUTION MELTING ANALYSIS; HIPPOCAMPAL TISSUE; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; REVERSE TRANSCRIPTION; RNA EXTRACTION; SPECTROPHOTOMETRY; ANIMAL; APOPTOSIS; CYPERUS; DRUG EFFECTS; GENETICS; HIPPOCAMPUS; METABOLISM; WISTAR RAT;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; BRAIN ISCHEMIA; CYPERUS; GENE EXPRESSION; HIPPOCAMPUS; MALE; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 84964203208     PISSN: 00446025     EISSN: 17359694     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Elmor S. Apoptosis: a Review of Programmed Cell death. Toxicologic Pathology 2007;35(4):495-516.
2. Saunders J. Death in embryonic systems. Science 1966;154(3749):604-12.
3. Sentman CL, Shutter JR, Hockenbery D, et al. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 1991;67(5):879-88.
4. Hossmann KA. Post-ischemic resuscitation of the brain selective vulnerability versus global resistance. Prog Brain Res 1985;63(1):3-7.
5. Kalogeris T, Christopher P, MaikeKrenz B, et al. Cell biology of Ischemia/Reperfusion Injury. Int Rev Cell Mol Biol 2012;298:229-317.
6. Kanduc D, Mittelman A. Cell death: Apoptosis versus necrosis (review). Int J Oncology 2002;21(1):165-70.
7. Jover-Mengual T, Zukin RS, Etgen Am. MAPK signaling iscritical to estradiol protection of CA1 neurons in global ischemia. Endocrinology 2007;148(3):1131-43.
8. Hu Xm, Zhang Y. Effects of sodium β-aescinonexpression of adhesion molecules and migration of neutrophils after middle cerebral artery occlusion in rats. Acta Pharmacol Sin 2004;25(7):869-75.
9. Francischetti I, Moreno JB. Leukocytes and the inflammatory response in ischemia-reperfusion injury. Rev Bras Cir Cardiovasc 2010;25(4):575-84.
10. Inal M, Kanbak G. Prevention of ischemia reperfusioninduced oxidative injury in the liver by allopurinol and pentoxifylline. Trans Med 2006;18:S29-32.
11. Imam MZ, Sumi CD. Evaluation of anti nociceptive Activity of hydromethanol extract of Cyperusrotundus in mice. BMC Complement Altern Med 2014;14:83
12. Movassaghi S, Sharifi ZN, Akhtarzadeh F. Effects of different doses of pentoxifylline on CA1 pyramidal cells of hippocampus following brain ischemia in rats. Adv Cogn Sci 2011;13(1):93-100.
13. Sari S, Hashemi M, Mahdian R, et al. The effect of Pentoxifylline on bcl-2 gene expression Changes in hyppoca-mpus after Ischemia-Reperfusion in Wistar Rats by a Quantitative RT -PCR Method. Iran J Pharm Res 2013;12(3):495-501.
14. Kamyab AR, Shahbazi S, Dibajnia P, et al. Development and application of real time quantitative polymerase chain reaction technique using SYBR green 1 in the diagnosis of down syndrome. Cell J 2010;12(2):249-56.
15. Kluck RM. Bcl2 family- regulated apoptosis in health and disease. Cell Health Cytoskel 2010;2(1):9-22.
16. Chen J, Graham SH, Nakayama M, et al. Apoptosis Repressor Gene Bcl2 and Bclxl are expressed in the rat brain following global ischemia. J Cereb Blood Flow Metab 1997;17(1):2-10.
17. Honkaniemi J, Stephen M. Global ischemia induces apoptosis -associated genes in hippocampus. Brain Res Mol Brain Res 1996;42(1):79-88.
18. Hashemi M. The study of pentoxifylline drug effects on renal apoptosis and BCL-2 Gene-expression changes following ischemic reperfusion injury in rat. Iran J Pharm Res 2014;13(1):181-9