Angiotensin-converting enzyme in smooth muscle cells promotes atherosclerosis - Brief report

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 6, 2016, Pages 1085-1089

  Chen, Xiaofeng ^a,b   Howatt, Deborah A ^b   Balakrishnan, Anju ^b   Moorleghen, Jessica J ^b   Wu, Congqing ^b   Cassis, Lisa A ^b   Daugherty, Alan ^b   Lu, Hong ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

angiotensin converting enzyme; angiotensins; atherosclerosis; endothelial cells; myocytes, smooth muscle

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CELLS BY BODY ANATOMY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; FEMALE; HYPERCHOLESTEROLEMIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CELL; SYSTOLIC BLOOD PRESSURE; TRANSGENIC MOUSE; ANIMAL; AORTIC DISEASES; ATHEROSCLEROTIC PLAQUE; BLOOD PRESSURE; DEFICIENCY; DISEASE COURSE; DISEASE MODEL; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHENOTYPE; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; AORTIC DISEASES; ATHEROSCLEROSIS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENDOTHELIAL CELLS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HYPERCHOLESTEROLEMIA; MALE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PEPTIDYL-DIPEPTIDASE A; PHENOTYPE; PLAQUE, ATHEROSCLEROTIC; RECEPTORS, LDL;

EID: 84964059068     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.307038     Document Type: Article

References (40)

1. Lu H, Cassis LA, Daugherty A, Atherosclerosis and arterial blood pressure in mice. Curr Drug Targets 2007 8 1181 1189
2. Wu C, Lu H, Cassis LA, Daugherty A, Molecular and Pathophysiological Features of Angiotensinogen: A Mini Review. N Am J Med. Sci (Boston) 2011 4 183 190
3. Ng KK, Vane JR, Conversion of angiotensin I to angiotensin II. Nature 1967 216 762 766
4. Aberg G, Ferrer P, Effects of captopril on atherosclerosis in cynomolgus monkeys. J Cardiovasc Pharmacol 1990 15 suppl 5 S65 S72
5. Campbell JH, Fennessy P, Campbell GR, Effect of perindopril on the development of atherosclerosis in the cholesterol-fed rabbit. Clin Exp Pharmacol Physiol Suppl 1992 19 13 17
6. Charpiot P, Rolland PH, Friggi A, Piquet P, Scalbert E, Bodard H, Barlatier A, Latrille V, Tranier P, Mercier C, ACE inhibition with perindopril and atherogenesis-induced structural and functional changes in minipig arteries. Arterioscler Thromb 1993 13 1125 1138
7. Kowala MC, Grove RI, Aberg G, Inhibitors of angiotensin converting enzyme decrease early atherosclerosis in hyperlipidemic hamsters. Fosinopril reduces plasma cholesterol and captopril inhibits macrophage-foam cell accumulation independently of blood pressure and plasma lipids. Atherosclerosis 1994 108 61 72
8. Hayek T, Attias J, Smith J, Breslow JL, Keidar S, Antiatherosclerotic and antioxidative effects of captopril in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol 1998 31 540 544
9. Hayek T, Attias J, Coleman R, Brodsky S, Smith J, Breslow JL, Keidar S, The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice. Cardiovasc Res 1999 44 579 587
10. Lu H, Balakrishnan A, Howatt DA, Wu C, Charnigo R, Liau G, Cassis LA, Daugherty A, Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis. Br J Pharmacol 2012 165 2000 2008. doi: 10.1111/j.1476-5381.2011.01712.x
11. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G, Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000 342 145 153. doi: 10.1056/NEJM200001203420301
12. Fox KM, European trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003 362 782 788
13. Ohishi M, Ueda M, Rakugi H, Naruko T, Kojima A, Okamura A, Higaki J, Ogihara T, Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans. J Hypertens 1997 15 1295 1302
14. Ribichini F, Pugno F, Ferrero V, Bussolati G, Feola M, Russo P, Di Mario C, Colombo A, Vassanelli C, Cellular immunostaining of angiotensin-converting enzyme in human coronary atherosclerotic plaques. J Am Coll Cardiol 2006 47 1143 1149. doi: 10.1016/j.jacc.2005.12.022
15. Diet F, Pratt RE, Berry GJ, Momose N, Gibbons GH, Dzau VJ, Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease. Circulation 1996 94 2756 2767
16. Mitani H, Bandoh T, Kimura M, Totsuka T, Hayashi S, Increased activity of vascular ACE related to atherosclerotic lesions in hyperlipidemic rabbits. Am J Physiol 1996 271 3 pt 2 H1065 H1071
17. Fukuhara M, Geary RL, Diz DI, Gallagher PE, Wilson JA, Glazier SS, Dean RH, Ferrario CM, Angiotensin-converting enzyme expression in human carotid artery atherosclerosis. Hypertension 2000 35 1 pt 2 353 359
18. Weiss D, Bernstein KE, Fuchs S, Adams J, Synetos A, Taylor WR, Vascular wall ACE is not required for atherogenesis in ApoE(-/-) mice. Atherosclerosis 2010 209 352 358. doi: 10.1016/j.atherosclerosis.2009.09.069
19. Esther CR, Marino EM, Howard TE, Machaud A, Corvol P, Capecchi MR, Bernstein KE, The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest 1997 99 2375 2385. doi: 10.1172/JCI119419
20. Cole J, Quach DL, Sundaram K, Corvol P, Capecchi MR, Bernstein KE, Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure. Circ Res 2002 90 87 92
21. Chen X, Lu H, Zhao M, Tashiro K, Cassis LA, Daugherty A, Contributions of leukocyte angiotensin-converting enzyme to development of atherosclerosis. Arterioscler Thromb Vasc Biol 2013 33 2075 2080. doi: 10.1161/ATVBAHA.113.301777
22. Rakugi H, Wang DS, Dzau VJ, Pratt RE, Potential importance of tissue angiotensin-converting enzyme inhibition in preventing neointima formation. Circulation 1994 90 449 455
23. Caldwell PR, Seegal BC, Hsu KC, Das M, Soffer RL, Angiotensin-converting enzyme: vascular endothelial localization. Science 1976 191 1050 1051
24. Orfanos SE, Armaganidis A, Glynos C, Psevdi E, Kaltsas P, Sarafidou P, Catravas JD, Dafni UG, Langleben D, Roussos C, Pulmonary capillary endothelium-bound angiotensin-converting enzyme activity in acute lung injury. Circulation 2000 102 2011 2018
25. Daugherty A, Rateri DL, Lu H, Inagami T, Cassis LA, Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation 2004 110 3849 3857. doi: 10.1161/01.CIR.0000150540.54220.C4
26. Lu H, Rateri DL, Feldman DL, Charnigo RJ Jr, Fukamizu A, Ishida J, Oesterling EG, Cassis LA, Daugherty A, Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest 2008 118 984 993. doi: 10.1172/JCI32970
27. Lu H, Wu C, Howatt DA, Balakrishnan A, Charnigo RJ Jr, Cassis LA, Daugherty A, Differential effects of dietary sodium intake on blood pressure and atherosclerosis in hypercholesterolemic mice. J Nutr Biochem 2013 24 49 53. doi: 10.1016/j.jnutbio.2012.03.001
28. Ng KK, Vane JR, The conversion of angiotensin I to angiotensin II in vivo. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 1968 259 188 189
29. Cole JM, Xiao H, Adams JW, Disher KM, Zhao H, Bernstein KE, New approaches to genetic manipulation of mice: tissue-specific expression of ACE. Am J Physiol Renal Physiol 2003 284 F599 F607. doi: 10.1152/ajprenal.00308.2002
30. Shen XZ, Li P, Weiss D, Fuchs S, Xiao HD, Adams JA, Williams IR, Capecchi MR, Taylor WR, Bernstein KE, Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Am J Pathol 2007 170 2122 2134. doi: 10.2353/ajpath.2007.061205
31. Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, Obrien DA, Smithies O, Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 1995 375 146 148. doi: 10.1038/375146a0
32. Esther CR Jr, Howard TE, Marino EM, Goddard JM, Capecchi MR, Bernstein KE, Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest 1996 74 953 965
33. Gurley SB, Riquier-Brison AD, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM, AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab 2011 13 469 475. doi: 10.1016/j.cmet.2011.03.001
34. Rateri DL, Moorleghen JJ, Balakrishnan A, Owens AP III, Howatt DA, Subramanian V, Poduri A, Charnigo R, Cassis LA, Daugherty A, Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice. Circ Res 2011 108 574 581. doi: 10.1161/CIRCRESAHA.110.222844
35. Arnal JF, Battle T, Rasetti C, Challah M, Costerousse O, Vicaut E, Michel JB, Alhenc-Gelas F, ACE in three tunicae of rat aorta: expression in smooth muscle and effect of renovascular hypertension. Am J Physiol 1994 267 5 pt 2 H1777 H1784
36. Wassmann S, Czech T, van Eickels M, Fleming I, Böhm M, Nickenig G, Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice. Circulation 2004 110 3062 3067. doi: 10.1161/01.CIR.0000137970.47771.AF
37. Wu C, Xu Y, Lu H, Howatt DA, Balakrishnan A, Moorleghen JJ, Vander Kooi CW, Cassis LA, Wang JA, Daugherty A, Cys18-Cys137 disulfide bond in mouse angiotensinogen does not affect AngII-dependent functions in vivo. Hypertension 2015 65 800 805. doi: 10.1161/HYPERTENSIONAHA.115.05166
38. Lu H, Wu C, Howatt DA, Balakrishnan A, Moorleghen JJ, Chen X, Zhao M, Graham MJ, Mullick AE, Crooke RM, Feldman DL, Cassis LA, Vander Kooi CW, Daugherty A, Angiotensinogen exerts effects independent of angiotensin II. Arterioscler Thromb Vasc Biol 2016 36 256 265. doi: 10.1161/ATVBAHA.115.306740
39. Cassis LA, Rateri DL, Lu H, Daugherty A, Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. Arterioscler Thromb Vasc Biol 2007 27 380 386. doi: 10.1161/01.ATV.0000254680.71485.92
40. Rateri DL, Moorleghen JJ, Knight V, Balakrishnan A, Howatt DA, Cassis LA, Daugherty A, Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice. PLoS One 2012 7 e51483. doi: 10.1371/journal.pone.0051483